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Method for enabling bone cement to generate heat subsequently

A bone cement and subsequent technology, applied in medical science, prosthesis and other directions, can solve the problems of reduced polymerization heat temperature, poor treatment effect, limited tumor treatment effect, etc., achieving good biocompatibility and improving long-term efficacy. Effect

Active Publication Date: 2015-02-18
山东上品医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The heat of polymerization of acrylic resin bone cement in the body decreases quickly, and drops to the temperature of the human body after 1 to 3 minutes, so the therapeutic effect on tumors is limited
Acrylic resin bone cement has no bioactivity and degradability, and acrylic resin bone cement has no bioactivity and degradability, and most antitumor drugs are embedded in the deep part of the bone cement and cannot be released, resulting in the treatment of bone tumors. not effectively
Patent CN 101288781 B discloses a method for promoting the local drug release of antibiotic-loaded bone cement, and the drug release effect is not satisfactory after verification
and will 125 I is mixed into bone cement, and bone tumors are treated by internal radiation, because 125 The limitation of the irradiation radius of I and the uncertainty of particle distribution, and 125 I has a half-life and the overall therapeutic effect is not good

Method used

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  • Method for enabling bone cement to generate heat subsequently
  • Method for enabling bone cement to generate heat subsequently
  • Method for enabling bone cement to generate heat subsequently

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Group 1: 20g of acrylic resin bone cement powder and 0.5mg of gold nanorods were fully stirred and mixed, and 10ml of liquid material was added, fully stirred until the late stage of wire drawing or the early stage of dough, injected into a cylindrical mold with a diameter of 1.5cm, and the insertion test temperature range was 0~200℃ thermometer.

[0026] Group 2: 20g of acrylic resin bone cement powder was directly added to 10ml of acrylic resin bone cement liquid, and then injected into a cylindrical mold with a diameter of 1.5cm to form, and a thermometer with a temperature range of 0-200°C was inserted.

[0027] Record the temperature changes of the two respectively. For specific results, see figure 1 . The results showed that there was no difference between the bone cement with gold nanorods and ordinary bone cement, and the gold nanorods had no effect on the heat release of bone cement polymerization.

Embodiment 2

[0028] Example 2: In vitro temperature release of gold nanorods at different concentrations

[0029] Mix 20g of acrylic resin bone cement powder with 0.1mg~0.6mg of gold nanorods to form a mixture; pour 10ml of acrylic resin bone cement liquid into the above mixture, stir well until the drawing stage or the early dough stage, and inject a diameter of A 1.5cm cylindrical mold was formed, and a thermometer with a test temperature range of 0-200°C was inserted; after the acrylic resin bone cement was cured for 24 hours, it was irradiated with infrared rays with a wavelength of 550 nm to 1550 nm. The gold nanorod has a diameter of 10-40nm and a length of 30nm-100nm. figure 2 The energy of the infrared light on the surface can be converted into heat by the nano-gold, which improves the polymerization heat temperature of the bone cement.

Embodiment 3

[0030] Example 3: The mechanical strength of different concentrations of gold nanorods and common bone cement

[0031] Mix 20g of acrylic resin bone cement powder with 0.1mg, 0.3mg and 0.5mg of gold nanorods, add 10ml of acrylic resin bone cement powder, stir well until the late drawing or early dough, and inject into a cylinder with a diameter of 1.5cm Shape the mold and insert a thermometer with a test temperature range of 0~200°C. After the acrylic resin bone cement is cured and cured for 24 hours, the infrared laser generator and the acrylic resin bone cement block are irradiated at a distance of 15cm, and the temperature changes of the three are shown in image 3 . The results showed that the rate and degree of temperature increase of acrylic resin bone cement were closely related to the amount of gold nanorods added. .

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Abstract

The invention provides a method for enabling bone cement to generate heat subsequently, which is used for enabling the bone cement to achieve the temperature, at which peripheral tumour cells are killed. The method for enabling the bone cement to generate heat subsequently disclosed by the invention comprises the following steps of: uniformly mixing powder of nano-gold and acrylic resin bone cement to form a mixture; pouring material liquid of the acrylic resin bone cement into the mixture, and sufficiently stirring till a drawing period or an early dough period; and, after the acrylic resin bone cement is solidified, irradiating a bone cement block by utilizing infrared ray according to survival or development conditions of the tumour cells. According to the invention, the bone cement and the nano-gold are mixed, so that the effects of strengthening and treating damaged bone tissue are taken; furthermore, by means of subsequent infrared irradiation, the internal bone cement achieves a certain temperature to kill the peripheral tumour cells; and thus, the long-term effect for treating bone tumours is improved.

Description

technical field [0001] The invention relates to the release of bone cement heat, in particular to a method for releasing bone cement heat, which is applied to the fields of primary and secondary malignant bone tumors of vertebral bodies, long bones, irregular bones, and the like. Background technique [0002] The number of tumor patients is increasing day by day, and the corresponding number of primary and secondary malignant tumors of the bone is correspondingly increasing. Bone tumors destroy and dissolve bone tissue, resulting in a reduction or disappearance of bone load-bearing capacity, causing severe pain and movement disorders; Soft tissue mass invades normal tissues and nerves through mass effect or direct infiltration, affecting the patient's mobility and even leading to paraplegia. Bone tumors seriously affect the quality of life of patients and always threaten their lives. Conventional radiotherapy and chemotherapy can not improve the load-bearing capacity of bon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50
Inventor 孙钢刘训伟钟建李敏彭湘涛王志国
Owner 山东上品医疗器械有限公司
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