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Application of non-pathogenic cell-related component and pharmaceutical composition containing non-pathogenic cell-related component

A non-pathogenic and compositional technology, applied in drug combinations, medical preparations containing active ingredients, drug delivery, etc., to achieve the effects of reducing safety risks, non-toxic systemic safety, and low local irritation

Pending Publication Date: 2022-04-12
CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, there is still a need to develop new drugs for the treatment of local disease (such as tumors) to meet various clinical needs that cannot be met by existing technologies.

Method used

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  • Application of non-pathogenic cell-related component and pharmaceutical composition containing non-pathogenic cell-related component
  • Application of non-pathogenic cell-related component and pharmaceutical composition containing non-pathogenic cell-related component
  • Application of non-pathogenic cell-related component and pharmaceutical composition containing non-pathogenic cell-related component

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0095] According to the preparation method of the present invention, the preparation of the pharmaceutical composition of the present invention comprises the following steps: preparing an optional drug containing the cell-related components, the synergistic components and other substances that may exist according to the amount ratio and / or the administration concentration. A pharmaceutical preparation for topical administration. In one embodiment, the pharmaceutical composition of the present invention can be prepared by a method comprising the following steps: 1), preparing the cell-related components; 2), administering the required amount according to the concentration required for the therapeutic effect The cell-related components, synergistic components, and optional other components are mixed evenly; 3), if necessary, the mixture is divided according to the volume ratio of the drug volume / target volume required for the therapeutic effect and cover; 4), if necessary, steri...

Embodiment approach

[0111] 1. The use of non-pathogenic cell-related components as active ingredients that can provide therapeutic effects in the preparation of locally administrable pharmaceutical compositions for treating local lesions.

[0112] 2. The application according to item 1, wherein the pharmaceutical composition further comprises one or more chemically active ingredients or / and biologically active ingredients capable of producing synergistic effects with the non-pathogenic cell-related components, and in the In the above pharmaceutical composition, the ratio of the cell-related component to the chemically active component (cell-related component concentration / chemically active component concentration) is (1-110) / (1-100) or (1.5-100 ) / (0.1-1), or / and the ratio of the cell-related component to the biologically active component (cell-related component concentration / bioactive component concentration) is (60-180) / (0.1-60) .

[0113] 3. A topically administrable pharmaceutical composition...

Embodiment 1

[0186] Embodiment 1: the preparation of composition

[0187] Numerous different compositions of the present invention can be formulated according to the preparation methods of the compositions of the present invention described above. The compositions of some compositions of the present invention prepared in this example are listed in Table 2 (the cell-related components are prepared from animal tissues), Table 3 (the cell-related components are prepared from animal cells) and Table 4 (the cell-related components are prepared from prebiotic bacteria preparation). The cell specific volume listed in the table, wherein the cell specific volume of the tissue is provided by the veterinarian of the relevant animal experiment company, and the cell specific volume of the blood and cell concentrate is determined according to the method of blood routine measurement (for example, using the automatic blood cell analyzer BC 5000) .

[0188] Table 2

[0189]

[0190] Several examples ...

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Abstract

The present disclosure relates to treatment of topical lesion diseases by topical administration, uses of non-pathogenic cell-related components, and pharmaceutical compositions comprising non-pathogenic cell-related components. Specifically, the present disclosure relates to the application of a cell-related component as an active ingredient capable of providing a therapeutic effect including a synergistic effect in the treatment of a local lesion disease, a pharmaceutical composition comprising the cell-related component, and a pharmaceutical kit.

Description

technical field [0001] The present disclosure relates to the treatment of locally diseased diseases by topical administration. Specifically, the disclosure of the present application relates to the application of cell-related components as active ingredients that can provide therapeutic effects including synergistic effects in the treatment of local lesions, pharmaceutical compositions containing the cell-related components, and a method for treating local lesions. way of disease. Background technique [0002] Solid tumors are a classic research model for locally diseased disease. A solid tumor is a tumor disease with tumor symptoms, which is a characteristic diseased tissue containing tumor cells. Taking pancreatic cancer tumors as an example, pancreatic cancer cells only account for about 30% of the tumor volume. It can be seen that in addition to tumor cells, there are often a large number of other components (sometimes also called the microenvironment of tumor cells) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P35/00A61P29/00A61P5/00A61P17/00A61K35/12A61K35/741A61K36/00A61K36/02A61K9/00
Inventor 邹方霖邹礼常王建霞王艺羲
Owner CHENGDU KUACHANGAOPU MEDICAL TECH CO LTD
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