Macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof

Abstract

Disclosed are a macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof. The bone restoration comprises a macroscopic pore metal structural body, a microscopic pore structural body and nanofibers. The appearance of the macroscopic pore metal structural body is consistent with an anatomic form of defect part bone tissues, the size of internal macroscopic pores is 300-1500 micrometers, porosity ranges from 50% to 90%, microscopic roughness Ra of pore walls is 5-30 micrometers, all the macroscopic pores are communicated with one another completely, mechanical property of the macroscopic pore metal structural body is compatible with that of the defect part bone tissues, compressive strength is 60-300MPa, and elasticity modulus is 0.5-30GPa. The microscopic pore structural body is positioned in the macroscopic pore metal structural body, internal microscopic pores are uniform in structure and are communicated with one another completely, the pore size is 50-250 micrometers, and pore walls of the microscopic pores consist of the nanofibers which are made of biodegradable polymer materials. The bone restoration perfectly integrates the anatomic form, the mechanical property and biological property and can be applied to treatment of large segmental bone defects of bearing parts clinically.

Description

technical field [0001] The invention relates to a novel surgical implant, in particular to a macro-micro-nano hierarchical mechanically adaptive bone restoration and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] Bone defect caused by disease and trauma is a common clinical disease and one of the worldwide problems in orthopedic treatment, seriously affecting the quality of life of patients. At present, the methods for treating bone defects include autologous bone and allogeneic bone transplantation, biodegradable biomaterials and medical metal material transplantation, and tissue engineering techniques. Although autologous bone is good, its source is limited, and it will cause unnecessary secondary trauma to patients; allogeneic bone has disadvantages such as immunogenicity and pathogenicity; degradable biomaterials are widely used in clinical practice due to their good biocompatibility. It has been w...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to address the deficiencies of the prior art, to provide a macro-micro-nano hierarchical structural mechanically adaptive bone prosthesis and its preparation method, to overcome the existing bone prosthesis appearance and mechanical properties and bone tissue anatomy at the defect site Defects that do not match the physical morphology and mechanical properties, and construct a macro-micro-nano hierarchical structure feature, regulate cell behavior, and endow bone restorations with excellent biological properties

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