Macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof

A bone restoration and hierarchical structure technology, applied in the field of biomedical engineering, can solve the problems of bone tissue anatomical morphology and mechanical properties mismatch, and achieve excellent biological performance

Inactive Publication Date: 2014-10-22
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to address the deficiencies of the prior art, to provide a macro-micro-nano hierarchical structural mechanically adaptive bone prosthesis and its preparation method, to overcome the existing bone prosthesis appearance and mechanical pr

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  • Macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof
  • Macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof

Examples

Experimental program
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Example Embodiment

[0033] Example 1

[0034] First, use Mimics software to reconstruct the three-dimensional bone model of the patient’s defect based on the patient’s CT data; second, use commercial CAD software, such as Unigraphics, Pro / E, Catia, etc., based on the mechanical properties of the bone tissue of the defect and actual clinical needs. , Design the CAD model of the macroporous metal structure, the size of the macroporous metal structure is 800 microns, the porosity is 70%, the compressive strength is 120MPa, and the elastic modulus is 10GPa; the designed CAD model of the macroporous metal structure is connected to the defect site of the patient The three-dimensional model of the skeleton is subjected to Boolean operations to form a CAD model of the macroporous metal structure whose anatomical shape is consistent with the bone model of the patient's defect site; according to the anatomical shape of the CAD model of the macroporous metal structure consistent with the bone model of the patie...

Example Embodiment

[0035] Example 2

[0036] Firstly, according to the patient's MRI data, use Mimics software to reconstruct the three-dimensional bone model of the patient's defect; secondly, use commercial CAD software, such as Unigraphics, Pro / E, Catia, etc., according to the mechanical properties of the bone tissue of the defect and actual clinical needs. , Design the CAD model of the macroporous metal structure, the macroscopic pore size is 300 microns, the porosity is 90%, the compressive strength is 60MPa, and the elastic modulus is 0.5GPa; the designed CAD model of the macroporous metal structure and the patient defect The three-dimensional model of the bones of the part is subjected to Boolean operations to form a CAD model of the macroporous metal structure whose anatomical shape is consistent with the bone model of the patient's defect part; according to the anatomical shape of the CAD model of the macroporous metal structure consistent with the bone model of the patient's defect part, ...

Example Embodiment

[0037] Example 3

[0038] First, use Mimics software to reconstruct the three-dimensional bone model of the patient’s defect based on the patient’s CT data; second, use commercial CAD software, such as Unigraphics, Pro / E, Catia, etc., according to the mechanical properties of the bone tissue of the defect and actual clinical needs. , Design the CAD model of the macroporous metal structure, the size of the macropore is 1500 microns, the porosity is 50%, the compressive strength is 300MPa, and the elastic modulus is 30GPa; the designed CAD model of the macroporous metal structure is connected to the defect site of the patient The three-dimensional model of the skeleton is subjected to Boolean operations to form a CAD model of the macroporous metal structure whose anatomical shape is consistent with the bone model of the patient's defect site; according to the anatomical shape of the CAD model of the macroporous metal structure consistent with the bone model of the patient's defect s...

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Abstract

Disclosed are a macroscopic-microcosmic-nanometer hierarchical mechanical compatible bone restoration and preparation thereof. The bone restoration comprises a macroscopic pore metal structural body, a microscopic pore structural body and nanofibers. The appearance of the macroscopic pore metal structural body is consistent with an anatomic form of defect part bone tissues, the size of internal macroscopic pores is 300-1500 micrometers, porosity ranges from 50% to 90%, microscopic roughness Ra of pore walls is 5-30 micrometers, all the macroscopic pores are communicated with one another completely, mechanical property of the macroscopic pore metal structural body is compatible with that of the defect part bone tissues, compressive strength is 60-300MPa, and elasticity modulus is 0.5-30GPa. The microscopic pore structural body is positioned in the macroscopic pore metal structural body, internal microscopic pores are uniform in structure and are communicated with one another completely, the pore size is 50-250 micrometers, and pore walls of the microscopic pores consist of the nanofibers which are made of biodegradable polymer materials. The bone restoration perfectly integrates the anatomic form, the mechanical property and biological property and can be applied to treatment of large segmental bone defects of bearing parts clinically.

Description

technical field [0001] The invention relates to a novel surgical implant, in particular to a macro-micro-nano hierarchical mechanically adaptive bone restoration and a preparation method thereof, belonging to the technical field of biomedical engineering. Background technique [0002] Bone defect caused by disease and trauma is a common clinical disease and one of the worldwide problems in orthopedic treatment, seriously affecting the quality of life of patients. At present, the methods for treating bone defects include autologous bone and allogeneic bone transplantation, biodegradable biomaterials and medical metal material transplantation, and tissue engineering techniques. Although autologous bone is good, its source is limited, and it will cause unnecessary secondary trauma to patients; allogeneic bone has disadvantages such as immunogenicity and pathogenicity; degradable biomaterials are widely used in clinical practice due to their good biocompatibility. It has been w...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/56A61L27/50A61L27/04
Inventor 李祥
Owner SHANGHAI JIAO TONG UNIV
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