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Nano composition as well as preparation method and application thereof

A nano-composition and biological surface technology, which is applied in the direction of drug combination, pharmaceutical formula, cosmetic preparation, etc., can solve the problems of easy change of active ingredients, difficulty in achieving full-effect whitening or multiple skin care functions, low transdermal absorption efficiency, etc. problems, to achieve the effect of improving the transdermal absorption rate and bioavailability, shortening the transdermal action time, and enhancing the skin retention

Pending Publication Date: 2021-11-05
INST OF CHEM ENG GUANGDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many soothing, acne-removing, whitening, anti-aging and other cosmetics on the market, but these cosmetics generally have the following problems: (1) single function: most products only target one of acne-removing, whitening, anti-aging, etc. different effects, and for a certain mechanism of action
For example, whitening cosmetics are mostly aimed at the formation and transfer mechanism of melanin, and it is difficult to achieve full-effect whitening or multiple skin care functions
(2) Poor product stability: most functional cosmetics are prepared by emulsification and mixing of active ingredients and other formula ingredients, and active ingredients are prone to change during transportation, storage and use of cosmetics, resulting in reduced or lost cosmetic efficacy
For example, most anti-aging peptides, vitamins and phenolic actives are sensitive to enzymes, light, pH, etc. If directly added to the formula, it is easy to cause the inactivation of unstable active ingredients
(3) The transdermal absorption efficiency of active ingredients is low: due to the skin’s own barrier, it is difficult for active ingredients such as acne, whitening, and anti-aging to penetrate the stratum corneum of the skin and act on skin care targets, resulting in little skin care effect

Method used

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  • Nano composition as well as preparation method and application thereof
  • Nano composition as well as preparation method and application thereof
  • Nano composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A nanocomposite comprising 10% palmitate palmitate, 5% sesame oil, 0.5% paeonol, 5.0% azelaic acid, 4% polysorbate-80, 1% rhamnolipid, remaining water.

[0057] The nano composition in embodiment 1 adopts following preparation method to prepare:

[0058] According to mass percentage, 10% palmitic acid palmitate, 5% sesame oil are mixed, stirred under 50 ℃ of water bath conditions, obtain oily phase, set aside;

[0059] Mix 0.5% paeonol, 5.0% azelaic acid, 4% polysorbate-80, 1% rhamnolipid and the rest of the water, stir in a water bath at 50°C to obtain the water phase, and set aside;

[0060] Mix the oil phase with the water phase. After the mixing is completed, high-speed shearing and homogenization at a speed of 20,000 rpm for 2 minutes to obtain a dispersion; the dispersion is subjected to high-pressure micro-jet treatment, and circulated at room temperature and a homogenization pressure of 20,000 psi for 2 For the second time, the nanocomposition in Example 1 was...

Embodiment 2

[0062] A nano composition comprising 10% palmitate palmitate, 5% sesame oil, 0.5% paeonol, 5.0% azelaic acid, 4% polysorbate-80, 0.6% sucrose monolaurate , the remainder of the water.

[0063] The nano composition in embodiment 2 adopts following preparation method to prepare:

[0064] According to mass percentage, 10% palmitic acid palmitate, 5% sesame oil are mixed, stirred under 50 ℃ of water bath conditions, obtain oily phase, set aside;

[0065] Mix 0.5% paeonol, 5.0% azelaic acid, 4% polysorbate-80, 0.6% sucrose monolaurate and the rest of the water, stir in a water bath at 50°C to obtain a water phase, and set aside;

[0066] Mix the oil phase with the water phase. After the mixing is completed, high-speed shearing and homogenization at a speed of 20,000 rpm for 2 minutes to obtain a dispersion; the dispersion is subjected to high-pressure micro-jet treatment, and treated twice at room temperature and a homogenization pressure of 20,000 psi , to obtain the nano compos...

Embodiment 3

[0068] A nano composition comprising 10% palmitate palmitate, 5% sesame oil, 0.5% paeonol, 5.0% azelaic acid, 4% polysorbate-80, 1.0% surfactant and amount of water.

[0069] The nano composition in embodiment 3 adopts following preparation method to prepare:

[0070] According to mass percentage, 10% palmitic acid palmitate, 5% sesame oil are mixed, stirred under 50 ℃ of water bath conditions, obtain oily phase, set aside;

[0071] Mix 0.5% paeonol, 5.0% azelaic acid, 4% polysorbate-80, 1.0% surfactant and the rest of the water, stir in a water bath at 50°C to obtain a water phase, and set aside;

[0072] Mix the oil phase with the water phase. After the mixing is completed, high-speed shearing and homogenization at a speed of 20,000 rpm for 2 minutes to obtain a dispersion; the dispersion is subjected to high-pressure micro-jet treatment, and treated twice at room temperature and a homogenization pressure of 20,000 psi , to obtain the nanocomposition in Example 3, which is...

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Abstract

The invention discloses a nano composition as well as a preparation method and application thereof. The nano composition comprises a biological surfactant, active ingredients, lipid and water. The biological surfactant is adopted in the nano composition, so that various high-concentration water-soluble active ingredients and / or non-water-soluble active ingredients can be effectively wrapped, so that the transdermal delivery of various active ingredients can be realized, multiple effects and / or synergistic interaction are realized, the transdermal absorption rate and bioavailability of the active ingredients are improved, the transdermal action time is shortened, the skin retention volume is increased, and the instant and long-acting effects are achieved.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to a nanometer composition and its preparation method and application. Background technique [0002] At present, skin problems such as skin acne, inflammation, dullness, spots, wrinkle growth, and skin aging have begun to plague most women and men. These skin problems can be attributed to endogenous physiological reasons and exogenous environments factor. Physiological internal factors are related to genetic factors, microcirculation in the body, cell activity, hormone changes in the body, etc. Exogenous environmental factors are related to PM2.5 / NO x In addition, diet, stress, and living habits can also have an important impact on skin acne, spots, wrinkles, and inflammation. At present, there are many soothing, acne-removing, whitening, anti-aging and other cosmetics on the market, but these cosmetics generally have the following problems: (1) single function: most products only target ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/60A61K8/34A61K8/35A61K8/362A61K8/49A61K8/67A61K8/14A61Q19/00A61Q19/02A61Q19/08A61Q17/00A61P29/00
CPCA61K8/64A61K8/60A61K8/345A61K8/35A61K8/362A61K8/347A61K8/342A61K8/498A61K8/602A61K8/671A61K8/14A61Q19/00A61Q19/02A61Q19/08A61Q17/005A61P29/00A61K2800/524A61K2800/592
Inventor 陈佳志吕冉李媛柳亚锋张靖雯陈晓填麦裕良
Owner INST OF CHEM ENG GUANGDONG ACAD OF SCI
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