Compound temperature-sensitive gel for treating skin ulcer and preparation method thereof

A compound temperature-sensitive gel, the technology of the temperature-sensitive gel, which is applied in the directions of skin diseases, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Deterioration, good stability effect

Inactive Publication Date: 2013-04-24
卓阳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in clinical medicine, there are many methods for treating skin ulcers, but

Method used

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  • Compound temperature-sensitive gel for treating skin ulcer and preparation method thereof
  • Compound temperature-sensitive gel for treating skin ulcer and preparation method thereof
  • Compound temperature-sensitive gel for treating skin ulcer and preparation method thereof

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Embodiment Construction

[0013] The present invention will be further described below in combination with specific embodiments. It should be understood that this embodiment is only used to illustrate the present invention and embody the beneficial effects of the present invention, but not to limit the scope of the present invention. In addition, it is obvious that after reading the content taught by the present invention, relevant changes or modifications made by those skilled in the art based on the spirit of the present invention also fall within the protection scope of the present invention.

[0014] In order to fully illustrate the effect that the compound temperature-sensitive gel of the present invention can realize in clinical application, the subject group has taken the following self-control experiment on 30 rats: adopt female Wistar rats, fast them for 24h, and remove the skin on the back. Remove the hair, anesthetize with ether, cut off 4 pieces of circular skin with a diameter of 1.0 cm on...

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PUM

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Abstract

The invention relates to a compound temperature-sensitive gel for treating skin ulcer and a preparation method thereof. The compound temperature-sensitive gel is composed of insulin and recombinant human epidermal factor by taking one or more of poloxamer 407, poloxamer 188 and chitosan as a substrate; and the compound temperature-sensitive gel is prepared through preparation of a gel substrate, preparation of a mixed solution of the insulin and the recombinant human epidermal factor, preparation of the compound temperature-sensitive gel and observation of a sample in turn. The compound temperature-sensitive gel disclosed by the invention is in the liquid state in preparation and storage processes and easy to coat or spray at a wound, so that the compound temperature-sensitive gel is conveniently used clinically; gel can be rapidly formed under the body temperature condition; the gel is difficult to run away, effective for long-term retention and high in bioavailability; furthermore, due to the aqueous environment of the gel, biological activity of two protein medicaments can be ensured more easily; release of the two protein medicaments is more easy; and the preparation method of the compound temperature-sensitive gel disclosed by the invention is simple and practical and strong in operability.

Description

technical field [0001] The invention relates to a compound temperature-sensitive gel for treating skin ulcers and a preparation method thereof. Background technique [0002] Skin ulcers are wounds formed by localized skin defects, which can reach deep into the dermis or deeper. There are many types and complex etiologies: they can be caused by trauma, burn infection, vascular, diabetes, pressure, radiation damage, skin malignancies, etc. Because the damage often destroys the basal layer cells and reaches deep into the dermis or subcutaneous tissue, the ulcer heals slowly, and must go through the growth and proliferation of cells in each layer of the skin, and scars may be left after healing. At present, in clinical medicine, there are many methods for treating skin ulcers, but no drugs that have growth-promoting effects on cells in all layers of the skin have been found. Contents of the invention [0003] The object of the present invention is to provide a compound temper...

Claims

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Application Information

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IPC IPC(8): A61K38/28A61K9/06A61K47/42A61K47/36A61P17/02A61K38/18
Inventor 卓阳
Owner 卓阳
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