Compound temperature-sensitive gel for treating skin ulcer and preparation method thereof

Abstract

The invention relates to a compound temperature-sensitive gel for treating skin ulcer and a preparation method thereof. The compound temperature-sensitive gel is composed of insulin and recombinant human epidermal factor by taking one or more of poloxamer 407, poloxamer 188 and chitosan as a substrate; and the compound temperature-sensitive gel is prepared through preparation of a gel substrate, preparation of a mixed solution of the insulin and the recombinant human epidermal factor, preparation of the compound temperature-sensitive gel and observation of a sample in turn. The compound temperature-sensitive gel disclosed by the invention is in the liquid state in preparation and storage processes and easy to coat or spray at a wound, so that the compound temperature-sensitive gel is conveniently used clinically; gel can be rapidly formed under the body temperature condition; the gel is difficult to run away, effective for long-term retention and high in bioavailability; furthermore, due to the aqueous environment of the gel, biological activity of two protein medicaments can be ensured more easily; release of the two protein medicaments is more easy; and the preparation method of the compound temperature-sensitive gel disclosed by the invention is simple and practical and strong in operability.

Description

technical field [0001] The invention relates to a compound temperature-sensitive gel for treating skin ulcers and a preparation method thereof. Background technique [0002] Skin ulcers are wounds formed by localized skin defects, which can reach deep into the dermis or deeper. There are many types and complex etiologies: they can be caused by trauma, burn infection, vascular, diabetes, pressure, radiation damage, skin malignancies, etc. Because the damage often destroys the basal layer cells and reaches deep into the dermis or subcutaneous tissue, the ulcer heals slowly, and must go through the growth and proliferation of cells in each layer of the skin, and scars may be left after healing. At present, in clinical medicine, there are many methods for treating skin ulcers, but no drugs that have growth-promoting effects on cells in all layers of the skin have been found. Contents of the invention [0003] The object of the present invention is to provide a compound temper...

AI Technical Summary

Problems solved by technology

At present, in clinical medicine, there are many methods for treating skin ulcers, but no drugs that can promote the growth of cells in all layers of the skin have been found.

Images