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Salicylic acid solubilizing slow-release composition and preparation method and application thereof

A slow-release composition, a technology of salicylic acid, which is applied in the directions of pharmaceutical combinations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of complex production raw materials and processes, high requirements for production equipment and personnel, and high skin irritation.

Inactive Publication Date: 2019-05-21
HARMEN LEIMOGAOSHI ESSENCE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even if there is, for example, patent application CN105147596A (named as water-soluble supramolecular salicylic acid gel technology) and patent application CN105106108A (named as supramolecular controlled slow-release salicylic acid formula and its preparation technology) although water has been used in the formula Two ingredients, cylic acid and poloxamer, but it still uses the conventional method of dissolving salicylic acid, dissolving salicylic acid through a mixture of ethanol and propylene glycol, which is more irritating to the skin; and its production materials and processes are very complicated , not only need to prepare supermolecules such as starch nanocrystals, starch sodium poloxamer suspension, α-cyclodextrin aqueous solution, low-molecular fish collagen aqueous solution, but also need to adopt complex processes such as ultrasonic dispersion and freeze-drying. and higher requirements for personnel

Method used

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  • Salicylic acid solubilizing slow-release composition and preparation method and application thereof
  • Salicylic acid solubilizing slow-release composition and preparation method and application thereof
  • Salicylic acid solubilizing slow-release composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] Embodiment 1 (acne-removing lotion and preparation method thereof)

[0089] Composition and mass percent reference of table 1 embodiment 1

[0090] Component effect

chemical composition

Example 1(.%)

active ingredient

salicylic acid

0.1

Co-solvent

Poloxamer 407

1

moisturizer

1,3-Butanediol

0.05

moisturizer

glycerin

0.02

moisturizer

Hexylene glycol

0.03

Skin Feel Modifier

β-glucan

0.05

Skin Feel Modifier

Sodium hyaluronate

0.04

Skin Feel Modifier

sodium alginate

0.01

Anti-corrosion system

p-Hydroxyacetophenone

0.1

buffer

Sodium dihydrogen phosphate

-

solvent

Deionized water

98.6

[0091] Preparation method (refer to figure 1 or figure 2 flow chart):

[0092] According to the composition and mass percentage of Example 1 in Table 1, the acne-removing water product is prepared according to the foll...

Embodiment 2

[0096] Embodiment 2 (acne-removing essence and preparation method thereof)

[0097] Composition and mass percent reference of table 2 embodiment 2

[0098] Component effect

chemical composition

Example 2(.%)

active ingredient

salicylic acid

5

Co-solvent

Poloxamer 407

20

moisturizer

1,3-Butanediol

15

moisturizer

glycerin

10

moisturizer

Hexylene glycol

5

Skin Feel Modifier

β-glucan

15

Skin Feel Modifier

Sodium hyaluronate

4.5

Skin Feel Modifier

sodium alginate

0.5

Anti-corrosion system

p-Hydroxyacetophenone

10

buffer

Sodium dihydrogen phosphate

-

solvent

Deionized water

15

[0099] Preparation:

[0100] According to the composition and mass percentage of Example 2 in Table 2, prepare acne essence according to the following steps:

[0101] 1) Add salicylic acid and poloxamer 407 into deionized water, heat ...

Embodiment 3

[0104] Embodiment 3 (acne-removing gel and preparation method thereof)

[0105] Composition and mass percent reference of table 3 embodiment 3

[0106]

[0107]

[0108] Preparation:

[0109] According to the composition and mass percentage of Example 3 in Table 3, the gel product is prepared according to the following steps:

[0110] 1) Add salicylic acid and poloxamer 407 into deionized water, heat to 75 degrees Celsius, and stir until the solution is clear;

[0111] 2) Cool down to 45 degrees Celsius, add moisturizer, skin feel modifier, antiseptic system and deionized water, and stir until the solution is clear;

[0112] 3) Check and adjust the pH value to 2.5-3.0.

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PUM

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Abstract

The invention provides a salicylic acid solubilizing slow-release composition. The salicylic acid solubilizing slow-release composition is prepared from a specific proportion of active ingredient salicylic acid, solubilizing slow-release agent poloxamer 407, a humectant, a skin feeling conditioning agent, a preservative system and deionized water. The salicylic acid solubilizing slow-release composition has the advantages that under the conditions without alcohol and at a low pH value, the salicylic acid is prepared into a stable, easy-to-use and low-irritant water-soluble liquid, gel, or an intermediate state between the water-soluble liquid and the gel; on one hand, the solubility of the salicylic acid in an aqueous phase can be significantly improved, thereby increasing the biological utilization rate of the salicylic acid, on the other hand, the irritation of the salicylic acid to the skin can be significantly reduced, thereby solving the technical problem of the high-concentrationsalicylic acid intolerance of wide crowds. In addition, the invention further relates to a preparation method and application of the salicylic acid solubilizing slow-release composition.

Description

technical field [0001] The invention belongs to the technical field related to cosmetics and its preparation, and specifically relates to a water-soluble solubilizing buffer whose main components are composed of salicylic acid and poloxamer, and which include moisturizing agent, skin feeling regulator, antiseptic system and deionized water. release formulations, preparation methods and uses. Background technique [0002] Salicylic acid, also known as salicylic acid, is a beta hydroxy acid (BHA) extracted from plants such as willow or poplar with the formula C 7 h 6 o 3 , in the form of white fine needle crystals or white crystalline powder, with antipyretic, analgesic and anti-inflammatory effects. Salicylic acid has lipophilic properties, can penetrate pores and dissolve dead skin cells, and is often widely used in cosmetics as an exfoliating agent. Specifically, salicylic acid can be used to treat dandruff, pimples, blackheads, acne, skin wrinkles, skin pigmentation, b...

Claims

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Application Information

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IPC IPC(8): A61K8/86A61K8/368A61Q19/00A61P17/10
Inventor 梅鹤祥陆婕胡晓芸
Owner HARMEN LEIMOGAOSHI ESSENCE
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