Antibacterial drug injection containing poloxamer 407 and oily medium

An antibacterial drug, oily medium technology, applied in antibacterial drugs, medical preparations containing active ingredients, pharmaceutical formulations, etc.
CN103705452AActive Publication Date: 2014-04-09荷本(北京)大药厂有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
荷本(北京)大药厂有限公司
Publication Date
2014-04-09

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Abstract

The invention discloses an oily long-acting injection containing antibacterial drug / poloxamer 407 drug-loading particles, which is prepared by combining the antibacterial drug with poloxamer 407 into drug-loading particles and further dispersing the drug-loading particles into an oily medium and grinding. Hydroxypropyl methyl cellulose or high-substituted hydroxypropyl cellulose also can be added into the drug-loading particles, and the sustained-release effect of the preparation is obviously enhanced. The preparation process of the injection is simple, the drug release is uniform, the biocompatibility is good, irreversible damage to the tissue of the injection part is avoided, and the adopted sustained-release carrier can be degraded and excreted.
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Description

Technical field

[0001] The invention belongs to the preparation technology of veterinary drug preparations, and specifically relates to the preparation of long-acting veterinary injections containing antibacterial drugs by using poloxamer 407 and an oily medium as carriers. Background technique

[0002] Poloxamer is a polyoxyethylene-polyoxypropylene ether copolymer. This type of polymer has a variety of specifications. Among them, the aqueous solution of poloxamer 407 (hereinafter referred to as P407) has the characteristic of "from sol to gel with increasing temperature" "Transformation characteristics", a certain concentration of P407 aqueous solution generally gels above 28°C. Based on this characteristic, P407 is used in the preparation of sustained-release injections, which are called in-situ gelling preparations. After the in-situ gel injection containing P407 is injected into the body, under the effect of body temperature, it usually changes from a sol to a gel (semi-soli...

Claims

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