Nano cubic liquid crystal dexamethasone preparation for eye and preparation method thereof

Abstract

The invention relates to a dexamethasone ophthalmic nano-cubic liquid-crystal preparation and a preparation method thereof. The dexamethasone ophthalmic nanocube crystal preparation is prepared from lipid materials, an emulsifying agent, a thickening agent, an osmotic pressure regulating agent, a bacteriostatic agent, a pH value regulating agent and purified water and characterized in that the amphipathic lipid capable of forming the cubic liquid-crystal morphology, one or more out of glyceryl monooleate (GMO), phytantriol and lecithin are adopted as the lipid materials; and the safe and non-irritant ophthalmic surfactant, one or more out of poloxamer 407 and polyvinyl alcohol (PVA) are adopted as the emulsifying agent. .The invention realizes the ophthalmic administration of dexamethasone, a fat-soluble drug, and has the advantages of high comfort level and non-irritant administration; and the invention can promote the drug to permeate into the corneal barriers after the ophthalmic administration, thereby achieving the effect of improving the ophthalmic bioavailability.

Description

Technical field [0001] The invention relates to a novel ophthalmic preparation of dexamethasone, in particular to a nano cubic liquid crystal preparation for ophthalmic use of dexamethasone. The invention also relates to a preparation method of the dexamethasone ophthalmic nano cubic liquid crystal preparation. Background technique [0002] Uveitis is a common eye disease. In the western eye diseases that cause blindness, uveitis accounts for 10%-15%. The main clinical manifestations are iridocyclitis, choroiditis and so on. The pathogenesis of uveitis is complicated. Except for infectious factors, most of them are caused by autoimmune response. Uveitis is regarded as a "difficult disease" in ophthalmology, and its treatment is quite difficult. [0003] The front of the eyeball is dense corneal tissue. The normal corneal epithelial layer is composed of 6-7 layers of epithelial cells, and there are close connections between epithelial cells. While performing normal physiological p...

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Problems solved by technology

At present, there have been research reports on the carrier in the fields of skin administration, intravenous injection and oral adm

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