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Heat-sensitive gel containing matrine alkaloid and its preparing method

A sensitive gel and matrine technology, applied in the field of heat-sensitive gels, can solve the problems of difficult gel viscosity control, unfavorable dispersion of affected parts, outflow, etc., achieve good heat-sensitive gel properties and prolong residence time , easy to clean effect

Inactive Publication Date: 2006-10-25
SHANGHAI HUATUO MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an ordinary gel, it has its inherent defects, that is, it is difficult to control the viscosity of the gel. If the viscosity of the gel is small, it will flow out of the body due to the dilution of physiological secretions at the application site; if the viscosity is high, use Difficult to disperse in the affected area
[0004] There is no report about heat-sensitive gels with matrine alkaloids as active pharmaceutical ingredients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Single-dose packaged thermosensitive gel for vagina (specification 2g / bottle, 1000 pieces)

[0026] Prescription: Component name Dosage (g)

[0027] Matrine 50

[0028] Hypromellose 17.46

[0029] Poloxamer 407 362

[0030] pH5.0 Phosphate Buffer 1368

[0031] Glycerin 200

[0032] Sorbic acid 2

[0033] Methylparaben 2

[0034] According to the prescription, each component is weighed, and matrine is added into the pH5.0 phosphate buffer solution, and stirred to dissolve. Add hypromellose to the obtained solution to dissolve, then add poloxamer 407 to stir and dissolve, and finally add sorbic acid, methyl p-hydroxybenzoate and glycerin to dissolve. Each unit preparation is 2g, divided into disposable vaginal injectors, plus outer packaging. Injected into the vagina when used.

Embodiment 2

[0035] The heat-sensitive gel for external genital mucous membrane of embodiment 2 multi-dose packaging (specification 5g / supports, 1000)

[0036] Prescription: Component name Dosage (g)

[0037] Oxymatrine 125

[0038] Hypromellose 45

[0039] Poloxamer 407 950

[0040] pH6.0 Phosphate Buffer 3320

[0041] Glycerin 550

[0042] Sorbic acid 10

[0043] According to the prescription, weigh each component, add oxymatrine into pH6.0 phosphate buffer solution, and stir to dissolve. Add hypromellose to the obtained solution to dissolve, then add poloxamer 407 to stir and dissolve, and finally add sorbic acid and glycerin to dissolve. 5 g per unit formulation, dispensed into spray bottles. Press and spray the affected area when using.

Embodiment 3

[0044] The thermosensitive gel for the vagina of embodiment 3 single-dose packaging (specification 5g / support, 1000)

[0045] Prescription: Component name Dosage (g)

[0046] Oxymatrine 100

[0047] Hypromellose 45

[0048] Poloxamer 407 900

[0049] pH5.5 Phosphate Buffer 3545

[0050] Glycerin 400

[0051] Sorbic acid 10

[0052] According to the prescription, weigh each component, add oxymatrine into pH5.5 phosphate buffer solution, and stir to dissolve. Add hypromellose to the obtained solution to dissolve, then add poloxamer 407 to stir and dissolve, and finally add sorbic acid and glycerin to dissolve. Each unit preparation is 5g, divided into disposable vaginal injectors, plus outer packaging. Injected into the vagina when used.

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Abstract

The present invention relates to a heat-sensitive gel preparation containing matrine alkaloid and its preparation method. Said preparation is composed of matrine alkaloid, hydroxypropyl methylcellulose, poloxamer 407, phosphate buffer solution whose pH value is 5.0-7.0, glycerin and preservative. It is flowable fluid at normal temperature, and when the temperature is 28-33 deg.C, it can produce phase change, and can be formed into gel, so that it can be conveniently applied to vagina, mucous membrane of external genitalia, skin and eye.

Description

technical field [0001] The present invention relates to a heat-sensitive gel containing matrine alkaloids, in particular to a medicinal composition containing matrine alkaloids as an active ingredient and poloxamer 407. The composition has Heat-sensitive gel, can be applied to human body parts such as vagina, eyes, external genital mucous membrane and common skin. The invention also relates to a preparation method of the thermosensitive gel preparation. Background technique [0002] Matrine alkaloids are a class of alkaloids with the chemical structure characteristics of matrine-15-one. They are mainly natural products isolated and extracted from plants Sophora flavescens and Sophora flavescens, including the total alkaloid parts (referred to as flavescens for short). total alkaloids) and monomeric compounds purified from matrine total alkaloids, such as matrine, oxymatrine, sophoridine, aloperine, sophocarpine, sophoramine, sophoryl, oxidized sophocarp alkali. Most matri...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K9/00A61P15/02
Inventor 潘俊芳张白晶沈慧兰朱勤
Owner SHANGHAI HUATUO MEDICAL SCI CO LTD
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