Oil injection containing tulathromycin/poloxamer 407

A technology of tebramycin and poloxamer, applied in the field of long-acting injections, can solve the problems of easy blocking of needles, difficulty in preparing high-concentration tebramycin injections, large volume, etc.
CN103768014AInactive Publication Date: 2014-05-07王玉万
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
王玉万
Publication Date
2014-05-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses combination of tulathromycin and poloxamer 407. The technology comprises the following steps: preparing medicine-carrying micro-particles; further dispersing the medicine-carrying micro-particles into oil medium; and preparing a long-acting oil injection containing tulathromycin and poloxamer 407 medicine-carrying micro-particles in a grinding manner. The injection is simple in preparation technology, good in slow-release effect, good in biocompatibility, and free of an irreversible damage to the tissue of the injection part.
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Description

technical field

[0001] The invention belongs to the preparation technology of veterinary drug preparations, and specifically relates to preparing telamycin and poloxamer 407 into drug-loaded microparticles, suspending the drug-loaded microparticles in an oily medium, and preparing long-acting injections containing telamycin drug-loaded microparticles. Background technique

[0002] Tulathromycin (Tulathromycin) is a macrolide semi-synthetic antibiotic for animals. It is mainly used in veterinary clinics for respiratory diseases in pigs and cattle caused by actinomycetes, mycoplasma, Pasteurella, and Haemophilus para It has the advantages of high efficiency, broad spectrum, one-time administration, and low residue. Tyramycin has low bioavailability when administered orally, and the commercially available products are mainly injections. Although the currently commercially available Tyramycin injections have high bioavailability, they are more irritating, and "often cause short-...

Claims

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