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Injectable Isatis Root in-situ gel, and preparation method thereof

A technology of in-situ gel and Radix Radix is ​​applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. Stress and other problems, to achieve the effect of reducing the frequency of administration, convenient administration, and low irritation

Inactive Publication Date: 2014-01-22
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In a course of treatment for the prevention and treatment of diseases such as pigs, sheep, cattle, dogs, and cats, Banlangen injection needs repeated injections and administration, which may easily cause obvious "peaks and valleys" in blood drug concentration, which is not conducive to antiviral, antibacterial and immune Adjustment and other functions are exerted, and frequent injections to catch animals are time-consuming and labor-intensive, which can easily cause animal stress and aggravate the condition

Method used

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  • Injectable Isatis Root in-situ gel, and preparation method thereof
  • Injectable Isatis Root in-situ gel, and preparation method thereof
  • Injectable Isatis Root in-situ gel, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] In situ gel for Radix isatidis injection (each 1mL is equivalent to 1.5g of the dried original drug)

[0028] prescription

[0029]

[0030] Preparation method: (a) take prescription amount of Radix Radix Radix crude drug (calculated as dry product), and prepare Radix Radix Radix Radix extract by conventional water extraction and alcohol precipitation; (b) add Tween-80, propylene glycol and benzyl alcohol into the Radix Radix Radix Radix extract, Then add water for injection to dilute to an appropriate concentration; (c) Sprinkle the prescribed amount of gel matrix and sodium carboxymethylcellulose on the above solution, and refrigerate at about 4°C overnight to obtain a clear, lump-free, and evenly dispersed solution , adjust the pH to 6.0-6.5 with sodium hydroxide, and filter through a 0.22 μm microporous membrane; (d) dilute (c) with water for injection, stir evenly, and obtain.

[0031] The prepared in situ gel was evaluated in vitro, including gelation temperat...

Embodiment 2

[0039] In situ gel for Radix isatidis injection (each 1mL is equivalent to 2.5g of dry raw medicine)

[0040] prescription

[0041]

[0042]

[0043] Preparation method: (a) take prescription amount of Radix Radix Radix crude drug (calculated as dry product), and prepare Radix Radix Radix Radix extract by conventional water extraction and alcohol precipitation; (b) add Tween-80, propylene glycol and benzyl alcohol into the Radix Radix Radix Radix extract, Then add water for injection to dilute to an appropriate concentration; (c) Sprinkle the prescribed amount of gel matrix and povidone on the water surface of the above-mentioned Radix Radix Radix solution, and refrigerate overnight at about 4°C to obtain a clear, lump-free, and uniformly dispersed solution. Adjust the pH to 6.0-6.5 with sodium hydroxide, filter through a 0.22 μm microporous membrane; (d) dilute (c) with water for injection, stir evenly, and obtain. The in vitro performance evaluation method is the same...

Embodiment 3

[0045] In situ gel for Radix isatidis injection (each 1mL is equivalent to 3.0g of dry raw medicine)

[0046] prescription

[0047]

[0048] Preparation method: (a) take the prescribed amount of Radix Radix Radix crude drug (calculated as dry product), and prepare Radix Radix Radix Extract by conventional water extraction and alcohol precipitation; (b) add Tween-80, propylene glycol and chlorobutanol to Extract Radix Radix Radix Then add water for injection to dilute to an appropriate concentration; (c) Sprinkle the prescribed amount of gel matrix and sodium alginate on the water surface of the above-mentioned Radix Radix Radix solution, and refrigerate overnight at about 4°C to obtain a clear, lump-free, and evenly dispersed solution. solution, adjust the pH to 6.0-6.5 with sodium hydroxide, and filter through a 0.22 μm microporous membrane; (d) dilute (c) to volume with water for injection, stir evenly, and obtain. The in vitro performance evaluation method is the same a...

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Abstract

The invention belongs to the field of medicinal preparations for animals, and relates to an injectable Isatis Root in-situ gel preparation, and a preparation method thereof. The injectable Isatis Root in-situ gel preparation comprises, by weight, 30.0-75.0 parts of an Isatis Root extract liquid, 14.5-31.5 parts of poloxamer 407, 0.7-9.5 parts of poloxamer 188, 0.02-10.0 parts of a high-molecular retarding agent, 0.01-10.0 parts of a solubilizing stabilizer, a proper amount of a pH adjusting agent and 0.01-3.0 parts of an antiseptic, and each milliliter of the obtained preparation equals to 1.5-5.0g of a dried raw medicine. The preparation is a free-flowing liquid at room temperature, forms a semisolid gel after intramuscular or hypodermic injection, is slowly released, realizes only one-time administration for one treatment course, and has the advantages of simple preparation, convenient administration and definite therapeutic effect. The preparation has anti-virus, anti-bacterium, anti-endotoxin and immunoloregulation effects, and is suitable for controlling diseases of animals comprising pigs, cattle, sheep, dogs, cats and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations for animals, and relates to an in-situ gel for Radix isatidis injection with a suitable phase transition temperature and a preparation method thereof. technical background [0002] Injectable in situ gel (injectable in situ gel) is to disperse the drug and the polymer in a suitable solvent, and inject it locally into the muscle or subcutaneously. Under the physiological conditions of the administration site, the polymer solidifies to form a semi-solid or solid drug. Glue depot, and through the continuous degradation of the polymer, the drug is continuously released to achieve a sustained release and long-acting effect. [0003] The temperature-sensitive in situ gel for injection is a low-viscosity liquid before use (at ambient temperature), and gels at the physiological temperature of the injection site to form a soft, lubricating, transparent solid or semi-solid gel, mostly poloxane Mu...

Claims

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Application Information

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IPC IPC(8): A61K36/195A61K36/315A61K47/34A61K9/06A61P31/00
Inventor 余祖功郭凡溪耿智霞田静
Owner NANJING AGRICULTURAL UNIVERSITY
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