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Medical antiblocking intelligent gel rubber material and preparation thereof

A gel material and smart gel technology, applied in medical science, surgery, etc., can solve the problems of inconvenient operation, non-fluidity, and difficult coverage, etc., and achieve high application value and good biocompatibility

Active Publication Date: 2008-12-10
HANGZHOU SINGCLEAN MEDICAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these types of anti-adhesion products all have the disadvantage of inconvenient operation during clinical use.
Membrane materials are not easy to cover uneven wounds, and the coverage range is affected by the size of the membrane material, and the coverage is incomplete. Although the anti-adhesion liquid solves the problem of fully covering the wound, it cannot solve the adhesion problem due to its high fluidity. Thus affecting the anti-adhesion effect; the gel material solves the problem of adhesion on the wound surface, and the anti-adhesion effect has been improved, but due to the characteristics of the gel, it does not have fluidity, and it is not easy to be uniform, fast, and comprehensive during clinical use. coverage of the wound

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1) Formula of medical anti-adhesion smart gel material: in mass fraction, kg / kg, %

[0019] Poloxamer 407 10%-40%

[0020] Hyaluronic Acid or Sodium Hyaluronate 0.1%-0.3%

[0021] Glycerin 5%-15%

[0022] Propylene Glycol 10%-20%

[0023] The rest is pure water

[0024] 2) Preparation of medical anti-adhesion smart gel material:

[0025] Disperse the required amount of poloxamer 407 in an ice bath (0°C) in a container filled with a certain amount of pure water and stir until dissolved; add hyaluronic acid or sodium hyaluronate, glycerin, and propylene glycol in sequence The remaining amount of pure water was dissolved to obtain a mixed solution, and then the mixed solution was added to the poloxamer 407 solution, and stirred evenly; Degassing, the pressure is -20kPa, time control: until there are no bubbles in the solution, a transparent and clear solution is obtained; the transparent and clear solution obtained above is filtered with a 0.22-0.45 μm microporous mem...

Embodiment 2

[0027] 1) Formula of medical anti-adhesion smart gel material: in mass fraction, kg / kg, %

[0028] Poloxamer 407 10%

[0029] Sodium Hyaluronate 0.1%

[0030] Glycerin 5%

[0031] Propylene Glycol 10%

[0032] Pure water 74.9%

[0033] 2) Preparation of medical anti-adhesion smart gel material: same as in Example 1

Embodiment 3

[0035] 1) Formula of medical anti-adhesion smart gel material: in mass fraction, kg / kg, %

[0036] Poloxamer 407 18%

[0037] Hyaluronic Acid 0.2%

[0038] Glycerin 10%

[0039] Propylene Glycol 15%

[0040] Pure water 56.8%

[0041] 2) Preparation of medical anti-adhesion smart gel material: same as in Example 1

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PUM

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Abstract

The invention relates to a medical temperature response intellectual gelatin material for preventing postoperative adhesions and a manufacturing method thereof. When the temperature is less than 20 DEG C, the material is colorless and clear liquid with good fluidity; when the temperature is heated to 20-40 DEG C, the material is transferred to be a steady gelatin state, and the transformation from a liquid state to be a gelatin state can be realized at body temperature; poloxamer 407 is taken as host material, after sodium hyaluronate, glycerin and propanediol with certain proportion are added, dissolution at low temperature, vacuum degassing, millipore filtration and autoclaving are adopted, thus forming the material. The gelatin material is filled in blocking bottles, Schering bottles and pre-filled injectors with fixed amount and is used in the clinical postoperative adhesions, the curative effect is good, and use is convenient.

Description

(1) Technical field [0001] The invention relates to a medical temperature-responsive intelligent gel material for preventing postoperative adhesion and a preparation method thereof. (2) Background technology [0002] Postoperative adhesion is one of the important medical problems to be solved urgently at home and abroad since the history of surgery. The vast majority of procedures performed in the surgical field involve the prevention of adhesions between tissues. Postoperative adhesions can cause serious complications, such as adhesive ileus in the abdomen and pelvis, recurrent laryngeal nerve injury after thyroid surgery, and female infertility caused by pelvic tissue adhesions. 90% of patients have different degrees of adhesions after operation, and 60% of patients need to take certain anti-adhesion measures. [0003] At present, the "short-term barrier" method is widely used in the world to prevent postoperative adhesions, that is, to implant isolation materials in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/04A61L31/14
Inventor 宋天春张玲
Owner HANGZHOU SINGCLEAN MEDICAL PROD
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