Azithromycin eye drops and preparation method thereof

A technology of azithromycin and eye drops, applied in pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as aging, and achieve the effects of low toxicity, long treatment time, and few systemic side effects
CN104055729AInactive Publication Date: 2014-09-24SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
Publication Date
2014-09-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses azithromycin eye drops and a preparation method thereof, the azithromycin eye drops comprise the following components by weight: 0.5-2.0% of azithromycin or azithromycin salt, 0-1.5% of cosolvent, 0.2-10% of poloxamer 407, 0.1-1.5% of deacetylated gellan gum, 0.1-9% of osmotic pressure regulator, 0.001-2% of antiseptic; pH value is adjusted to 5.5-7.5 by a pH conditioning agent, and injection water is the balance. The azithromycin eye drops contain ion sensitive and temperature sensitive gel matrix, and has dual gelling characteristic, compared with usage of a single matrix, the azithromycin eye drops have better characteristic, preparation technology is reasonable, stability of the azithromycin eye drops can be guaranteed, metering is easily and accurately controlled, little loss can be avoided, the therapeutic time of the medicine can be maintained for a longer time, the side effect is less, the azithromycin eye drops have good biocompatibility without influence of eyesight, and the survivability of the patients is good.
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Description

technical field

[0001] The invention relates to eye drops and a preparation method thereof, in particular to azithromycin eye drops and a preparation method thereof. Background technique

[0002] Azithromycin (Azithromycin, C 38 h 72 N 2 o 12 , molecular weight 748.99) is a new generation of macrolide antibiotics, which is relatively mature in clinical application at present. Compared with the parent raw material erythromycin, it is more stable to acids, has a broad antibacterial spectrum, long half-life, and is convenient to take. Much lower than erythromycin, less adverse reactions.

[0003] The mechanism of the antibacterial effect of azithromycin is to interfere with the synthesis of proteins by binding to the 50S ribosomal subunit of sensitive microorganisms. Azithromycin has a broad antibacterial spectrum and can inhibit a variety of Gram-positive bacteria, mycoplasma, chlamydia, spirochaete and rickettsia, etc.

[0004] There are a variety of microorganisms in t...

Claims

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