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Temperature-sensitive gel for skin injury and preparation method of temperature-sensitive gel

A skin injury and temperature-sensitive technology, applied in the field of temperature-sensitive gels and their preparations, can solve the problems of secondary injury to wounds, uneven application, complicated drug administration, etc., to prevent dehydration, facilitate drug administration, shorten Effects of the Wound Healing Cycle

Inactive Publication Date: 2017-05-10
XIAN HUIPU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the gels in the existing commercially available products have defects such as complicated administration, uneven application, and easy to cause secondary damage to the wound during the administration process.

Method used

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  • Temperature-sensitive gel for skin injury and preparation method of temperature-sensitive gel
  • Temperature-sensitive gel for skin injury and preparation method of temperature-sensitive gel

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preparation example Construction

[0019] A preparation method for a temperature-sensitive gel for skin damage, comprising the following steps:

[0020] Weigh 10 parts of sodium hyaluronate and dissolve it in water for injection, and stir well to obtain a sodium hyaluronate solution;

[0021] Weighing Poloxamer 407, 15 parts were dissolved in cold water for injection, and left to swell for 24 hours to obtain Poloxamer sol;

[0022] Dissolving 0.5 part of humectant, 0.01 part of antibacterial agent and 0.05 part of human epidermal growth factor in water for injection, and stirring evenly to obtain an aqueous solution;

[0023] The aqueous solution containing human epidermal growth factor and the sodium hyaluronate solution are slowly added into the poloxamer sol under the condition of stirring, and stirred evenly to prepare the thermosensitive gel.

[0024] Described preservative is potassium sorbate.

[0025] The humectant is one or both of glycerin and xylitol.

[0026] The molecular weight of the sodium hy...

Embodiment 1

[0030] A temperature-sensitive gel for skin damage, consisting of the following raw materials in parts by weight: poloxamer 407, 5 parts; preservative 0.01 part; human epidermal growth factor 0.002 part; moisturizing agent 0.5 part and 2 parts of sodium hyaluronate; the balance is water for injection.

[0031] A preparation method for a temperature-sensitive gel for skin damage, comprising the following steps:

[0032] Weigh 2 parts of sodium hyaluronate and dissolve it in 10 mL of water for injection, and stir well to obtain a sodium hyaluronate solution; weigh 5 parts of poloxamer 407 and dissolve it in 10 mL of water for injection, and let it stand for swelling for 24 hours to obtain polexamer 407. Loxamer sol; 0.5 part of humectant, 0.01 part of preservative, and 0.002 part of human epidermal growth factor were dissolved in 5 mL of water for injection, and stirred evenly to obtain an aqueous solution; the aqueous solution containing human epidermal growth factor and sodium...

Embodiment 2

[0034] A temperature-sensitive gel for skin damage, consisting of the following raw materials in parts by weight: Poloxamer 407, 15 parts; bacteriostatic agent 0.01 part; human epidermal growth factor 0.05 part; moisturizing agent 0.5 part and 10 parts of sodium hyaluronate; the balance is water for injection.

[0035] A preparation method for a temperature-sensitive gel for skin damage, comprising the following steps:

[0036] Weigh 10 parts of sodium hyaluronate and dissolve it in 10 mL of water for injection, and stir well to obtain a sodium hyaluronate solution; weigh 15 parts of poloxamer 407 and dissolve it in 10 mL of water for injection, and let it stand for swelling for 24 hours to obtain po Loxamer sol; 0.5 part of humectant, 0.01 part of antibacterial agent, and 0.05 part of human epidermal growth factor were dissolved in 5 mL of water for injection, and stirred evenly to obtain an aqueous solution; the aqueous solution containing human epidermal growth factor and s...

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Abstract

The invention discloses a temperature-sensitive gel for a skin injury and a preparation method of the temperature-sensitive gel and relates to the technical field of skin repair administration. The temperature-sensitive gel is prepared from the following raw materials in parts by weight: 5-20 parts of poloxamer 407, 0.01-0.1 part of a bacteriostatic agent, 0.001-0.05 part of a human epidermal growth factor, 0.2-1.0 part of a humectant, 2-10 parts of sodium hyaluronate and the balance of water for injection water. The temperature-sensitive gel is prepared from the poloxamer 407 as a main raw material, and exists in a solution form at a low temperature; administration is convenient; the temperature-sensitive gel is converted into a gel state at a high temperature and is smooth and soft in surface, free of thrill to the administration part, free of foreign body sensation and good in biocompatibility; the sodium hyaluronate is very high in biocompatibility, beneficial to long-term moisture retention of the skin and beneficial to tissue cell regeneration and is capable of compacting the skin and preventing dehydration; and the human epidermal growth factor has an acceleration effect on mucosa repairing of the skin injury, so that the wound healing cycle is shortened to meet the structure design and clinical requirements.

Description

technical field [0001] The invention relates to the technical field of drug administration for skin restoration, in particular to a temperature-sensitive gel for skin damage and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, responsible for protecting the body, regulating body temperature and sensing heat and cold. Complete skin can resist the invasion of microorganisms and bacteria in the external environment, and plays an important role in protecting the health of the body. [0003] In daily work and life, skin damage occurs from time to time due to external physical effects such as contusions, abrasions, scratches, and cuts. When the skin is damaged, the current routine treatment includes cleaning, disinfection, bandaging and so on. Although simple bandaging can temporarily protect the wound, it takes a long time to heal; the existing gel is popular because of its ease of use and good effect. However, the ge...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/10A61P17/02A61K31/728
CPCA61K38/1808A61K9/0014A61K9/06A61K31/728A61K47/10A61K2300/00
Inventor 吴晓军
Owner XIAN HUIPU BIOTECH CO LTD
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