Soluble microneedle arrays for buccal delivery of vaccines

A micro-needle and cheek technology, applied in the directions of micro-needles, drug devices, needles, etc., can solve the problems of long portal venous phase and slow degradation rate of biodegradable polymers, and achieve the effects of easy administration, simple and economical production

Inactive Publication Date: 2014-12-03
THERAJECT INC.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A potential disadvantage of biodegradable polymer microneedle arrays is that the degradation rate of biodegradable polymers is slow, resulting in a longer portal period

Method used

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  • Soluble microneedle arrays for buccal delivery of vaccines
  • Soluble microneedle arrays for buccal delivery of vaccines
  • Soluble microneedle arrays for buccal delivery of vaccines

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Embodiment Construction

[0038] Reference will now be made to the detailed description of the invention, as well as the embodiments illustrated in the accompanying drawings, wherein like reference numerals refer to like elements. The specific implementation is described below, and the present invention is explained in detail in conjunction with the accompanying drawings.

[0039] The practice of the present invention will employ, unless otherwise indicated, conventional methods of engineering, chemistry, biochemistry, pharmacology, and drug delivery, within the purview of those skilled in the art. These techniques are explained in detail in the literature. All publications, patents, and patent applications cited herein, whether supra or infra, are hereby incorporated by reference in their entirety.

[0040] Examples in which any part is connected to other parts include examples in which the parts are directly connected to each other and examples in which the parts are not directly connected to each o...

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Abstract

A buccal microneedle patch may be provided for vaccination. The buccal microneedle patch may include at least one of microneedles. The at least one microneedles may be configured to contain a predetermined vaccine and to penetrate an outside layer of a buccal mucosa for promptly delivering the predetermined vaccine.

Description

technical field [0001] The present invention relates to a dissolving microneedle array, in particular to a dissolving microneedle array for oral administration such as buccal vaccination. Background technique [0002] Vaccination is a cost-effective way of preventing infectious diseases. Many new types of vaccines, including proteins, polysaccharides, and deoxyribonucleic acid (DNA), have been developed for better and more effective vaccination and therapeutic purposes. The most common method of administration for vaccination is parenteral injection, but injection generally causes needle phobia, pain and discomfort, and local injury to the skin and muscles. Additionally, syringe-needle injections can pose a risk of hepatitis B and C, human immunodeficiency virus (HIV), and other viral infections unless the needle is discarded after a single use or care is taken to prevent accidental needle sticks by healthcare providers. Each year, an estimated 1 billion injections are adm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/00A61K9/00A61M5/00A61M5/32
CPCA61K2039/541A61K39/00A61M2037/0061A61M37/00A61K9/00A61M37/0015A61M2037/0046A61M2037/0023A61K9/0021A61K9/006A61P37/04Y02A50/30A61B17/205A61B2017/00004A61M2210/0625
Inventor 权圣润
Owner THERAJECT INC.
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