Hyaluronic temperature-sensitive gel and preparation method and application thereof

A technology of hyaluronic acid and temperature-sensitive gel, which is applied in the field of medicine, can solve the problems of long-term use, short de-colonization time, unfavorable operation of medical staff, etc., and achieve the effect of accelerating healing and preventing re-colonization

Inactive Publication Date: 2015-12-23
NANJING TZONE BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Chlorhexidine decolonization is currently done by bathing or scrubbing, but this method of decolonization has disadvantages: 1. It is not conducive to the operation of medical staff; 2. It takes a long time to operate; 3. The patient feels bad; 4. Decolonization The colonization time is short, and the dec

Method used

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  • Hyaluronic temperature-sensitive gel and preparation method and application thereof
  • Hyaluronic temperature-sensitive gel and preparation method and application thereof
  • Hyaluronic temperature-sensitive gel and preparation method and application thereof

Examples

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Embodiment 1

[0039] A hyaluronic acid thermosensitive gel, comprising the following components in mass percentage: 0.03% middle molecular weight hyaluronic acid, 0.06% small molecular weight hyaluronic acid, 0.05% chlorhexidine, 8% poloxamer 407, 0.1% hydroxypropyl Methyl cellulose, 0.05% hydroxyethyl cellulose, 0.1% polyethylene glycol, 0.1% glycerin, 0.01% pentylene glycol, 0.01% octane glycol, and the balance is water.

[0040] Medium molecular weight hyaluronic acid has a molecular weight of 1.0×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 5000.

[0041] Described chlorhexidine is chlorhexidine acetate.

[0042] The polyethylene glycol has a molecular weight of 400.

[0043] The water is purified water.

[0044] The preparation method of the above-mentioned hyaluronic acid thermosensitive gel comprises the following steps:

[0045] Step 1: Add poloxamer 407, hypromellose, and hydroxyethylcellulose into the required pure water, let stand for 24 hours, f...

Embodiment 2

[0050] A hyaluronic acid thermosensitive gel, comprising the following components in mass percentage: 0.04% middle molecular weight hyaluronic acid, 0.08% small molecular weight hyaluronic acid, 2% chlorhexidine, 25% poloxamer 407, 1% hydroxypropyl Methylcellulose, 0.5% hydroxyethyl cellulose, 1.0% polyethylene glycol, 1.0% glycerin, 0.2% pentylene glycol, 0.1% octane glycol, and the balance is water.

[0051] The molecular weight of medium molecular weight hyaluronic acid is 1.8×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 10000.

[0052] Described chlorhexidine is chlorhexidine gluconate.

[0053] The polyethylene glycol has a molecular weight of 600.

[0054] The water is water for injection.

[0055] The preparation method of the above-mentioned hyaluronic acid thermosensitive gel comprises the following steps:

[0056] Step 1: Add poloxamer 407, hypromellose, and hydroxyethylcellulose into the required pure water, let stand for 24 hours, ...

Embodiment 3

[0061] A hyaluronic acid thermosensitive gel, comprising the following components in mass percentage: 0.03% middle molecular weight hyaluronic acid, 0.06% small molecular weight hyaluronic acid, 0.3% chlorhexidine, 15% poloxamer 407, 0.3% hydroxypropyl Methyl cellulose, 0.2% hydroxyethyl cellulose, 0.5% polyethylene glycol, 0.5% glycerin, 0.01% pentylene glycol, 0.02% octane glycol, and the balance is water.

[0062] Medium molecular weight hyaluronic acid has a molecular weight of 1.5×10 6 Da; the molecular weight of small molecular weight hyaluronic acid is 5800.

[0063] Described chlorhexidine is chlorhexidine gluconate.

[0064] The polyethylene glycol has a molecular weight of 600.

[0065] The water is purified water.

[0066] The preparation method of the above-mentioned hyaluronic acid thermosensitive gel comprises the following steps:

[0067] Step 1: Add poloxamer 407, hypromellose, and hydroxyethylcellulose into the required pure water, let stand for 24 hours, ...

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Abstract

The invention discloses hyaluronic temperature-sensitive gel and a preparation method and application thereof. The hyaluronic temperature-sensitive gel comprises, by mass, 0.01-0.3% of medium-molecular-weight hyaluronic acid, 0.01-0.5% of small-molecular-weight hyaluronic acid, 0.05-2% of chlorhexidine, 8-25% of poloxamer 407, 0.1-1% of hydroxypropyl methylcellulose, 0.05-0.5% of hydroxyethyl cellulose, 0.1-1% of polyethylene glycol, 0.1-1.0% of glycerol, 0.01-0.2% of pentanediol, 0.01-0.1% of octanediol and the balance of water. The hyaluronic temperature-sensitive gel has efficacy of moisturizing, repairing and sterilizing, can form a protecting film on the surface of skin or damaged skin and is suitable for body surface de-planting and sterilization nursing and sterile maintaining of barrier damaged skin of skin trauma and postoperative wound surface of inpatients.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a hyaluronic acid temperature-sensitive gel and a preparation method and application thereof. Background technique [0002] Hyaluronic acid (HA), namely sodium hyaluronate, is a linear polysaccharide composed of repeating disaccharide units of β-D-N-acetylglucosamine and β-D-glucuronic acid bonded alternately. The molecules of hyaluronic acid can carry more than 500 times of water, can maintain the water in the extracellular matrix, promote cell migration and differentiation, have very excellent biocompatibility, and are recognized as the best moisturizing ingredients today, and are widely used In skin care products and cosmetics. [0003] Wound healing of human skin and mucous membranes is a process involving the reconstruction and regeneration of extracellular matrix by various cells and their secreted products. Maintaining the humidity of the wound surface has a very obvious promotin...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K9/06A61K47/38A61K47/34A61K47/10A61P17/02A61P31/04A61K31/155
Inventor 徐林金玉党永明虞文魁沈娟红
Owner NANJING TZONE BIOLOGICAL SCI & TECH
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