Medicinal preparation for promoting body surface wound healing and preparation method thereof

A pharmaceutical preparation and body surface technology, which is applied in the direction of pharmaceutical formulations, drug combinations, active ingredients of heterocyclic compounds, etc., can solve problems such as single action, lack of analgesic effect, and short duration of drug effect

Active Publication Date: 2020-11-24
SHANGHAI INST OF PHARMA IND CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Effective repair and wound healing after body surface injury has always been an important issue in clinical trauma (burn) trauma. At present, the therapeutic drugs for body surface injury have only a single anti-infection effect or a single analgesic effect.
[0004] The commonly used preparations for clinical prevention of wound infection are mainly creams, ointments, powders such as silver sulfadiazine, and clinically prepared and used suspensions, etc., all of which have certain defects, such as (1) poor drug penetration ability, insoluble in Water, (2) lack of analgesic effect, strong irritation when administered, (3) epidermal pigmentation, (4) cannot prevent body fluid evaporation, (5) short duration of drug effect

Method used

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  • Medicinal preparation for promoting body surface wound healing and preparation method thereof
  • Medicinal preparation for promoting body surface wound healing and preparation method thereof
  • Medicinal preparation for promoting body surface wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1: The influence of pharmaceutical preparation of the present invention on rat scald infected wound healing pigmentation

[0073] 1. Model copy:

[0074] The day before the experiment, rats were depilated on their backs: after shaving with a shaver, they were depilated with 10% sodium sulfide, and reared in a single cage.

[0075] The scald model adopts YLS-5Q desktop super temperature-controlled scald instrument, 3# vertebral scald head, 100°C, 15 seconds, pressure 500g, touching the skin, causing an area of ​​4cm on the back of the rat 2 , burn wounds from 2 degrees deep to 3 degrees superficial.

[0076] After 10 minutes, smear 0.2ml / rat's MRSA bacterial solution on the wound surface of rats (the amount of bacteria is 10 9 CFU / ml), 4 hours after the bacterial solution was applied, the drug was given to start the treatment.

[0077] 2. Experimental records:

[0078] During the experiment, the wound was photographed on the 14th day, and it can be seen th...

Embodiment 2

[0091] Embodiment 2: the effect of pharmaceutical preparation on wound healing of rat scald infection

[0092] 1. Model copy:

[0093]The day before the experiment, rats were depilated on their backs: after shaving with a shaver, they were depilated with 10% sodium sulfide, and reared in a single cage.

[0094] The scald model adopts YLS-5Q desktop super temperature-controlled scald instrument, 3# vertebrae, 100°C, 15 seconds, 500 grams of pressure, touching the skin, causing an area of ​​4cm on the back of the rat 2 , burn wounds from 2 degrees deep to 3 degrees superficial.

[0095] After 10 minutes, smear 0.2ml / only Pseudomonas aeruginosa bacterium liquid on rat wound surface (bacterial amount is 10 9 CFU / ml), 4 hours after the bacterial solution was applied, the drug was given to start the treatment.

[0096] 2. Experimental records:

[0097] During the experiment, the burn area was measured every 7 days, and the scab formation time was recorded, and the experiment was...

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Abstract

The invention relates to a medicinal preparation for promoting healing of body surface injury and a method for preparing the medicinal preparation. Silver sulfadiazine (a), pain killers (b), asiaticoside (c) and other pharmaceutically acceptable carriers (d) are compatible with one another according to suitable proportions to obtain the medicinal preparation. The medicinal preparation and the method have the advantages that the medicinal preparation has double synergistic antibacterial and pain alleviating functions, accordingly, healing of wound surfaces can be promoted, epidermis hyperpigmentation due to the silver sulfadiazine can be prevented, and scar can be reduced; the shortcomings of poor hydrophilicity after existing pain killers and existing silver sulfadiazine are directly compatible with one another and easiness in volatilizing moisture in wound surfaces can be overcome.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical preparation for promoting the healing of body surface injuries and reducing epidermal pigmentation and a preparation method thereof. The glucoside is prepared into a pharmaceutical preparation in an appropriate proportion, and relates to its application for promoting body surface wound healing and reducing epidermal pigmentation, especially for preventing colored scars caused by sulfadiazine silver deposition. Background technique [0002] Scalds, burns, mechanical injuries or explosions will damage the skin surface, lose the ability to protect the tissue, and easily cause bacterial infection. A large amount of tissue fluid exuded is conducive to bacterial reproduction. If the treatment is not timely and appropriate, it is easy to lead to more complicated wound injuries And serious, increase the complication rate of trauma, fatality rate and morbidity rate. T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/06A61K31/63A61K31/7024A61P17/02A61K31/445
CPCA61K31/445A61K31/63A61K31/7024A61K45/06A61K2300/00
Inventor 刘莉黄晓星王一飞郑斌田华洁徐晓涛王生孟立正马春梅梅其炳
Owner SHANGHAI INST OF PHARMA IND CO LTD
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