Silver sulfadiazine thermosensitive gel as well as preparation method and application thereof

Abstract

The invention discloses silver sulfadiazine thermosensitive gel as well as a preparation method and application thereof. The silver sulfadiazine thermosensitive gel is prepared from the following rawmaterials: silver sulfadiazine nanocrystalline, 11 to 20 weight percent of poloxamer 407, 0 to 4 weight percent of temperature regulator, 3 to 13 weight percent of humectant and the balance of water.The gel nanocrystallizes silver sulfadiazine so as to increase the surface area of the silver sulfadiazine and enhance the antibacterial effects; by taking the poloxamer as a gel substrate and utilizing the thermosensitive gelling properties, effective fitting and easiness in removal of wound are realized; meanwhile, the gel can be used as a drug reservoir, and further slow release and long-term effects of antibacterial drugs are achieved. The gel can be directly used on the surfaces suffering from trauma, bedsore and ulceration so as to realize the effects of isolating, resisting bacteria, promoting wound healing and the like. The gel provided by the invention has the advantages that a substrate and components of the gel are both safe and non-toxic biomaterials and can be widely used in treatment and repair of clinical acute and chronic wound infection.

Description

technical field [0001] The invention relates to the technical field of temperature-sensitive in-situ gels, in particular to a silver sulfadiazine temperature-sensitive gel and a preparation method and application thereof. Background technique [0002] Trauma often leads to complications such as infection, excessive inflammation, and diabetic ulcers. Ordinary gel dressings are difficult to fight against more stubborn complications, especially infection. Because the wound exudate is rich in protein and other nutrients, it provides good conditions for the growth of microorganisms, so the wound surface is very easy to be infected. When infection occurs, microorganisms can decompose wound collagen and granular tissue, destroy new matrix, and cause excessive accumulation of macrophages and inflammatory cells, delay wound healing, and even lead to wound deterioration and systemic sepsis. In order to control wound infection, especially when the wound tissue is necrotic, lacks blood...

AI Technical Summary

Problems solved by technology

Currently commercially available silver sulfadiazine is mostly ointment applied to the affected area. The concentration of silver sulfadiazine is 1.0%. , requiring an increase in the number of administrations (2 to 4 times a day), however, multiple administrations will cause the accumulation of silver ions, which will lead to problems such as vascular toxicity, keratinocyte and fibroblast toxicity (Sandri et al., 2014; Brandt et al., 2012; Muller et al., 2003 and Tsipouras et al., 1995)

At the same time, repeated administration will cause problems such as transient pain, uneven application, difficulty in contacting the wound, and poor patient compliance.

[0004] In the literature about silver sulfadiazine preparations, there are obvious defects in the preparations. For example, the patent application with publication number CN104013574A discloses a suspension preparation of temperature-variable painless nanometer sulfadiazine metal compound hyaluronic acid. The phase transition temperature is set at 37°C, which fails to fully consider the human skin temperature (32°C), which is obviously not conducive to the transition to the gel form, and the sulfadiazine metal compound in the suspension state is prone to drug burst release

At present, there are no relevant reports on the market of sulfadiazine silver thermosensitive gel products at home and abroad

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