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467 results about "Chronic wound care" patented technology

A chronic wound is a wound that does not heal in an orderly set of stages and in a predictable amount of time the way most wounds do; wounds that do not heal within three months are often considered chronic. Chronic wounds seem to be detained in one or more of the phases of wound healing.

Wound healing polymer compositions and methods for use thereof

The present invention provides bioactive polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The composition can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are covalently attached to a biocompatible, biodegradable polymer and / or embedded within a hydrogel. Methods of using the invention bioactive polymer compositions to promote natural healing of wounds, especially chronic wounds, are also provided. Examples of biodegradable copolymer polyesters useful in forming the blood-compatible, hydrophilic layer or coating include copolyester amides, copolyester urethanes, glycolide-lactide copolymers, glycolide-caprolactone copolymers, poly-3-hydroxy butyrate-valerate copolymers, and copolymers of the cyclic diester monomer, 3-(S)[(alkyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione, with L-lactide. The glycolide-lactide copolymers include poly(glycolide-L-lactide) copolymers formed utilizing a monomer mole ratio of glycolic acid to L-lactic acid ranging from 5:95 to 95:5 and preferably a monomer mole ratio of glycolic acid to L-lactic acid ranging from 45:65 to 95:5. The glycolide-caprolactone copolymers include glycolide and ε-caprolactone block copolymer, e.g., Monocryl or Poliglecaprone.
Owner:MEDIVAS LLC

Microbial cellulose wound dressing for treating chronic wounds

The invention relates to a dressing comprised of microbial-derived cellulose for aesthetic application The dressing is capable of donating liquid to dry substrates and is also capable of absorbing exudating wounds. Delivery of various medicaments using the dressing is possible. Positive clinical outcomes including reduced pain and discomfort, faster epithelialization, and healing were observed with use of the dressing.
Owner:LOHMANN & RAUSCHER

Wound care polymer compositions and methods for use thereof

The present invention provides wound healing or wound care polymer compositions that can be formulated to release a wound healing agent at a controlled rate by adjusting the various components of the composition. The compositiona can be used in an external wound dressing, as a polymer implant for delivery of the wound healing agent to an internal body site, or as a coating on the surface of an implantable surgical device to deliver wound healing agents that are dispersed in a biodegradable polymer or hydrogel, or both. Methods of using the invention bioactive polymer compositions to deliver wound healing agents that promote natural healing of wounds, especially chronic wounds, are also provided.
Owner:MEDIVAS LLC

Method and apparatus for treating wound using negative pressure therapy

Devices that employ external compression stocking-type garments in the treatment of edema, chronic wounds, deep venous thrombosis prevention or claudication all share a number of significant limitations. These include the frequent need for custom fitting to assure an appropriate fit, vigilant maintenance to assure a continued “good fit,” limited compliance with proper use by patients and difficulty of application. There is a large body of evidence demonstrating that patients often decline to wear the compressive stockings as prescribed or in the form that would be most beneficial because they find these devices to be difficult to put on and take off.Building on the limitations of existing therapies, and distilled lessons learned from the field of prosthetics and wound healing, the present invention employs vacuum-assisted negative pressure to provide compression and help pump fluid from the tissues of affected limbs. The device is embodied in the form of a flexible stocking-like garment that will utilize a pumping mechanism to generate negative pressure around the limb and thus create vacuum compression that will mobilize fluid in a limb and increase venous return to the heart. Through the use of a circumferential wrap, the present invention provides a major advance in both the distribution of vacuum and the securing of the device over the limb.
Owner:THERANOVA LLC

Topical compositions for the treatment of chronic wounds

InactiveUS20060286108A1Avoid actionLow cytotoxicityBiocideAntibody ingredientsTace inhibitorEfalizumab
Methods for treating chronic wounds in a human are described by topically administering a dermatological composition comprising a TNF antagonist, a TACE inhibitor, a neutrophil antagonist, or a combination of a TNF antagonist and / or TACE inhibitor and a neutrophil antagonist. The TNF antagonist administered includes alefacept, efalizumab, etanercept, adalimumab, and onercept, while the neutrophil antagonist administered includes dapsone, colchicine, its analogs and prodrugs. The combination of TNF-antagonist and neutrophil antagonist administered includes sulfapyridine, sulfasalazine, mesalamine, and derivatives and prodrugs thereof. The topical compositions can be formulated to include the one or more of the antagonists in dissolved, semi-dissolved, and micro-particulate states.
Owner:BELL DERMATOLOGICS

Biocidal compositions and methods of using the same

An antimicrobial composition with synergistic biocidal activity is described which comprises at least one antimicrobial polymeric biguanide and at least one antimicrobial vicinal diol, said vicinal diol comprises at least one monoalkyl glycol, monoalkyl glycerol, or monoacyl glycerol, to diminish or eliminate biofilm communities. Such synergistic interaction is effective in wound treatment, particularly for chronic wounds, burns and battlefield-induced wounds, as well as for disinfecting non-biological surfaces. The antimicrobial composition can also be prepared as viscous solutions or as gels. The antimicrobial composition may be added to a substrate and dried, such as to a catheter, or to a foam, or to a fiber wound dressing, or coated as a viscous solution or gel upon such devices, to provide controlled release antimicrobial activity.
Owner:ROCHAL TECH LLC

Use of stem cells for wound healing

InactiveUS20110020291A1Promote wound healingMinimizing formation of scar tissueBiocideEpidermal cells/skin cellsInjury mouthChronic wound
Cells, compositions, and methods of cell therapy for administering a therapeutically effective amount of stem cells or cell concentrate to achieve accelerated wound healing of normal and chronic wounds, while minimizing the formation of scar tissue.
Owner:RUTGERS THE STATE UNIV

Wound care device

A wound care device comprising foam composition wherein the retention factor Rv=R / Δ?V of the foam is at least 0.05 wherein R is the retention capacity (g / g) and Δ?V is the expansion of volume (% v / v) of the foam when wetted. A wound care device comprising foam with a high retention and low expansion of volume is achieved, which is desired in the treatment of wounds, especially chronic wounds.
Owner:COLOPLAST AS

Method for treatment of wound treatment using aganocides

Provided herein is a method for the treatment of a wound using a wound treatment regimen for treating a chronic wound, the regimen comprising: a) applying reduced pressure to the wound; and b) treating the wound with a substantially non-toxic, non-irritating inorganic aganocide composition while applying reduce pressure to the wound.
Owner:NOVABAY PHARM INC

Electrosurgical system and method for treating chronic wound tissue

An electrosurgical method for treating chronic wound tissue, comprising: positioning an active electrode in close proximity to the chronic wound, the active electrode being disposed on a distal end of an electrosurgical shaft; applying a high-frequency voltage potential difference across the active electrode and a return electrode sufficient to develop a high electric field intensity associated with a vapor layer proximate the active electrode and in close proximity to the wound tissue; and stimulating an expression of at least one healing mediator.
Owner:ARTHROCARE

Medical hydrogel dressing and preparation method thereof

The invention relates to a wound healing hydrogel dressing applicable to nursing various acute and chronic wounds and a preparation method. The hydrogel dressing comprises a hydrogel layer, a fixing non-woven fabric and a medical adhesive tape, the hydrogel layer is fixed on a surface of the non-woven fabric, and the other surface of the non-woven fabric is adhered on the medical adhesive tape. The preparation method includes fixing cross-linking agent on the non-woven fabric; coating solution of a raw material of hydrogel onto one surface of the non-woven fabric, adhering the other surface of the non-woven fabric onto the medial adhesive tape with pressure-sensitive adhesive after crosslinking is finished, arranging the pressure-sensitive adhesive onto one surface of the medical adhesive tape while arranging a separate film backing on the other surface of the medical adhesive tape, and attaching an isolating film on one surface of the hydrogel; and sterilizing after the medical hydrogel dressing is packaged. The medical hydrogel dressing is convenient in use, can rapidly absorb exudation of the wound, prevents the exudation of the wound from excessively steeping the wound, creates a moist wound healing condition, and promotes wound healing. A self-adhesion function of the wound healing hydrogel dressing is greatly convenient for clinic service.
Owner:烟台万利医用品有限公司

Lysine in therapeutic angiogenesis, particularly in treating ischaemic conditions

Present invention features methods for induction of angiogenesis by administration of lysine (l-&d-) or lysine oligomers (molecular weight approx between 500 and 2500), both homo and hetero-oligomers, consisting of either l-or d- or both enantiomers. Induction of Angiogenesis by the methods of the invention can be use in therapeutic angiogenesis, in, for example, treatment of ischaemic conditions and syndromes, such as chronic wounds (e.g diabetic wounds and ulcers, bed sores and other pressure sores, burns of various degrees and extents etc.) as well as coronary and cerebral ischaemia and peripheral vascular ischaemic conditions. Induction of angiogenesis by the described methods also will be useful in inducing / enhancing radiosesitivity in some solid tumors.
Owner:DATTA DEBATOSH

Arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing

The present invention relates to the field of electrotherapy and measuring by means of electric currents for diagnostic purposes, and more particularly to an electrode arrangement for facilitating wound healing, a method for measuring wound healing and a wound dressing having an electrode arrangement. A wound dressing according is described which includes at least two impedance reference electrodes, a frame like counter-electrode and stimulation electrodes in a form of an array; and a bioadhesive affinity layer surrounding the stimulation electrodes; said wound dressing being suited for applying on top of the wound so that the stimulation electrode array is on the wound area, and that the at least two impedance reference electrodes and the frame like counter-electrode are suited for placing in contact with the healthy skin surrounding the wound area; which electrodes, are suited for applying LIDC type electrical stimulation current to the wound area and for bioimpedance measurement. The wound dressing can provide a continuous, non-invasive and objective solution for monitoring chronic wound healing without disturbing the delicate healing process.
Owner:CUTOSENSE OY

Preparation Method of an Anti-Microbial Wound Dressing and the Use Thereof

The present invention discloses a method for the preparation of an anti-microbial wound dressing comprises alkalizing chitosan fiber to obtain alkalized chitosan fiber which is then etherified with chloroacetic acid to produce carboxymethyl chitosan fiber. Said fiber is made into dressing by fiber opening, web formation and needling. Alternatively chitosan fiber can be made into chitosan non-woven fabric by non-woven technique first which is then carboxylmethylated. The fabric is then made into wound dressing by cutting, packaging and sterilizing. The present invention also discloses the uses of the anti-microbial wound dressing made according to said method. The dressing according to the present invention can be applied in surgical wound, burn, and other chronic wound. Said dressing, when covering wound, is able to prevent moisture losses in body fluid, provide a favorable moist environment necessary for wound healing and maintain a fluid-free, maceration-free, germ-free wound surface. Said dressing is antiphlogistic, hemostatic and antalgic and promotes wound healing.
Owner:MEDTRADE PROD

Compress for medical treatment

A medical compress for use in treating chronic wounds includes a non-woven textile fabricated from air laid fibers containing a superabsorbent material. The superabsorbent material is enclosed by a knitted mesh which can be formed to the shape of the wound. An irrigation solution is preferably contained by the compress to keep the wound irrigated and to encourage healing.
Owner:IVF HARTMANN AG

Use of one or more natural or modified oxygen carriers, devoid of plasma and cellular membrane constiuents, for externally treating open, in particular chronic wounds

The present invention relates to the use of one or more natural or modified oxygen carriers, devoid of plasma or cellular membrane constituents, for the production of an agent for the external treatment of open wounds, particularly chronic wounds. Hemoglobin or myoglobin of human or animal origin are suitable as oxygen carriers. The oxygen carriers can also preferably be modified. Suitable modifications are cross-linking, reaction with polyalkylene oxides, chemically reactive or chemically non-reactive effectors, or combinations. The agent is applied to the wound area particularly by means of spraying on an aqueous solution containing the oxygen carrier(s). The oxygen carriers can be used in particularly effective manner in the case of chronic wounds resulting from tissue degeneration, particularly diabetic tissue degeneration.
Owner:SANGUIBIOTECH

Materials and methods for wound treatment

The subject invention pertains to methods and compositions for wound treatment. The methods and compositions provide for promoting and accelerating wound healing; provide for inhibition of microbial infection; provide for a protective scab-like covering on a wound; and / or for arresting the flow of blood or body fluids from an open wound. The methods and compositions can be used to increase granulation and epithelialization in a wound. In one embodiment, a substantially anhydrous compound of a salt ferrate and a cation exchange material is provided. Compositions of the invention can also include silver compounds. In use, compositions of the invention are preferably applied as a dry dressing to an exuding chronic wound site. If the chronic wound site is dry, the wound site may be wetted with a suitable liquid or aqueous media prior to applying the dressing in dry form.
Owner:BIOLIFE

Methods and compositions for wound healing

Assays employing fibronectin-depleted substrates are described to identify invasion inducing agents. Such agents are useful for in vivo wound healing, including but not limited to deep wounds and chronic wounds.
Owner:MICHIGAN UNIV OF RGT THE

Electrosurgical system and method for sterilizing chronic wound tissue

An electrosurgical method for sterilizing chronic wound tissue, comprising: positioning an active electrode in proximity to the chronic wound tissue; delivering an electrically conductive fluid proximate the active electrode; and applying a high frequency voltage between the active electrode and a return electrode in the presence of the electrically conductive liquid sufficient to generate an ionized vapor layer at the active electrode, wherein the ionized vapor layer sterilizes at least a portion of the chronic wound tissue.
Owner:ARTHROCARE

Genipin cross-linked biogel as well as preparation method and application thereof

The invention discloses genipin cross-linked biogel as well as a preparation method and application thereof. The genipin cross-linked biogel comprises the following raw materials in percentage by weight: 0.05wt%-0.2wt% of genipin, 1wt%-10wt% of matrix and the balance of water. By carrying out crosslinking by virtue of optimized genipin concentration, the obtained biogel has the properties of low toxicity, good water-absorbing property and mechanical property and the like. The biogel can be directly used for protecting and isolating the surfaces of various wounds, bedsores and ulcers, can be used as a dressing carrier to load antibacterial drugs, paregorics, growth factors and the like, and can be applied to the treatment of wound infection, wound analgesia or promotion of wound healing and the like. According to the genipin cross-linked biogel, the matrix, a crosslinking agent and the components are all derived from natural organisms, so that the biogel is safe and non-toxic and can be widely applied to the treatment and repair of clinical acute and chronic wounds.
Owner:FIELD OPERATION BLOOD TRANSFUSION INST OF PLA SCI ACAD OF MILITARY

External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof

The invention provides an external traditional Chinese medicine preparation for treating chronic wounds, which is prepared from the following raw medicines in parts by weight: 10-20 parts of draconis sanguis, 10-20 parts of chuanxiong rhizome, 10-20 parts of notoginseng, 10-20 parts of fried sanguisorba, 10-20 parts of safflower, 10-20 parts of spatholobus stem, 10-20 parts of giant knotweed, 10-20 parts of oldenlandia, 10-20 parts of red sage root, 10-20 parts of herba patriniae, 10-20 parts of moutan bark, 10-20 parts of myrrh, 10-20 parts of mastic, 10-20 parts of rhubarb, 10-20 parts of natural indigo, 10-20 parts of gromwell, 10-20 parts of catechu, 10-20 parts of borneol, 10-20 parts of phellodendron bark and 10-20 parts of boneset. The external traditional Chinese medicine preparation provided by the invention can promote healing of infectious wounds, increase pus, enhance qualitative viscosity and regenerate granulation to enable the wounds to quickly heal, has an obvious effect on treating wound infection, and can be used for treating partial ulcer, removing necrotic tissue and promoting granulation, accelerating the degeneration process of the necrotic tissue, promoting dilation of capillary vessels, accelerating microcirculation of the capillary vessels and filling the wounds.
Owner:李惠斌

Antibacterial fiber dressing containing nanometer metal and preparation method thereof

InactiveCN102631699AAvoid infectionLong-term and effective antibacterial functionAbsorbent padsBandagesFiberWound dressing
The invention relates to an antibacterial fiber dressing containing nanometer metal and a preparation method thereof. Nanometer metal particles are distributed on the fiber surface of the dressing. The content of the nanometer metal is 0.5-10 wt%. As a dressing for wound treatment, the fiber wound dressing has the capability of continuously releasing sufficient nanometer metal particles, is especially suitable for chronic wound treatment, can provide long-term and effective antibacterial functions, and can effectively prevent wound infection caused by various bacteria and microbe.
Owner:FOSHAN UNITED MEDICAL TECH +1

Antibacterial self-healing hydrogel dressing capable of accelerating healing of chronic wounds as well as preparation method and application thereof

ActiveCN108904875AExcellent temperature sensitivityNo residueBandagesChemical synthesisSelf-healing hydrogels
The invention discloses an antibacterial self-healing hydrogel dressing capable of accelerating healing of chronic wounds as well as a preparation method and application thereof. The method comprisesthe following steps: firstly oxidizing sodium hyaluronate, sodium alginate and pulullan through a strong oxidant to obtain polysaccharide with aldehyde group, then forming a polymer with network withcationic polymers such as epsilon-polylysine, polyethyleneimine and chitosan through Schiff base reaction, then fully mixing the polymer with F127 to form a hydrogel with a dual-network structure, finally loading exosome on the cationic polymers through electrostatic effect, coating the exosome in the hydrogel with the dual-network structure to obtain the antibacterial self-healing hydrogel dressing capable of accelerating healing of the chronic wounds. The preparation method is simple and is free of organic solvent residues; the used chemical synthesis method is environmentally friendly and is convenient to operate and low in raw material cost.
Owner:XI AN JIAOTONG UNIV

Medical dressing loaded with nano silver and bioactive factors and preparation method thereof

The invention relates to a preparation method of chronic wound dressing, and in particular, relates to a medical dressing loaded with nano silver and bioactive factors and a preparation method thereof. The dressing includes calcium alginate, chitosan or a chitosan derivative as a matrix and is loaded with nano silver antibacterial composition particles and a growth factor EGF. During preparation,calcium alginate core microspheres wrapped with the growth factor are obtained by dropwise adding a sodium alginate solution mixed with the growth factor into a calcium chloride solution. The microspheres are added to a chitosan acetic acid solution to form a polyelectrolyte complex. Then the polyelectrolyte complex is mixed and stirred with nano silver and chitosan, the mixture is added to sodiumalginate, crosslinking and freeze-drying are performed, and finally, the chronic wound dressing loaded with nano silver and the growth factor is formed. The raw materials of the method are cheap andeasy to obtain, the preparation process is stable, the bacteriostatic performance of the chronic wound dressing is good, and the wound repair ability is excellent. The dressing is used for treating various chronic wounds caused by cancer radiotherapy, diabetes, ischemia and the like, and induces cleaning and repairing of the wounds.
Owner:南昌大学第一附属医院
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