Preparation method of composite antibacterial dressing loaded with silver sulfadiazine

A silver sulfadiazine and compound antibacterial technology, which is applied in the field of biomedical materials, can solve the problems of unfavorable wound healing, uneven application, easy pollution and deterioration, etc., and achieve a good humid environment, avoid secondary trauma, and good biocompatibility Effect

Active Publication Date: 2015-07-22
NANJING FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is often combined with medical auxiliary materials to make ointment to smear wounds, which has disadvantages such as uneven application, wound irritation, poor permeability, easy contamination and deterioration, and easy adhesion, which is not conducive to wound healing

Method used

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  • Preparation method of composite antibacterial dressing loaded with silver sulfadiazine
  • Preparation method of composite antibacterial dressing loaded with silver sulfadiazine
  • Preparation method of composite antibacterial dressing loaded with silver sulfadiazine

Examples

Experimental program
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Effect test

Embodiment 1

[0034]Prepare 100 mL of seed culture with yeast extract (5 g / L), glucose (5 g / L), potassium dihydrogen phosphate (1 g / L), magnesium sulfate heptahydrate (15 g / L) and peptone (5 g / L) respectively base and 200mL of fermentation medium without adjusting the pH. Put the seed medium and fermentation medium into a sterilizing pot at a temperature of 121°C and a pressure of 0.1MPa, and sterilize for 20 minutes. After the culture medium is cooled, add ethanol (20mL / L). The activated Acetobacter xylinum was inoculated into the seed medium, and cultured in a shaker at 30° C. and 160 rpm / min for 24 h. According to the inoculum amount of 6% (volume ratio, within the range of 5-10%), inoculate the seed culture solution into the fermentation medium and shake it well to mix it evenly, and then culture it statically at 30±2°C for 1-2 weeks. A milky white bacterial cellulose film was obtained. Rinse the residues on the surface of bacterial cellulose with deionized water, soak in 0.1M NaOH so...

Embodiment 2

[0036] The method is the same as in Example 1, the difference is that the bacterial cellulose homogeneous suspension and sodium alginate solution are mixed with a mass ratio of 1:1 to generate a gel, then stirred evenly with silver sulfadiazine, then ultrasonically degassed, and solidified , and finally freeze-dried in vacuum at -80°C to obtain a silver-sulfadiazine-loaded composite antibacterial dressing.

Embodiment 3

[0038] The method is the same as in Example 1, the only difference is that 0.8mg silver sulfadiazine is added to the mixed gel of 5g bacterial cellulose and sodium alginate, the weight ratio of silver sulfadiazine is 0.016%, after stirring evenly, ultrasonic degassing Processing, solidification, and finally vacuum freeze-drying at -80°C to obtain a silver sulfadiazine-loaded composite antibacterial dressing.

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Abstract

The invention discloses a preparation method of a composite antibacterial dressing loaded with silver sulfadiazine. The preparation method comprises steps as follows: (1), bacterial cellulose is obtained through static fermentation of acetobacter xylinum; (2), the bacterial cellulose is beat after alkali washing to be prepared into a homogeneous-phase suspension liquid; (3), a sodium alginate solution is prepared; (4), silver sulfadiazine is subjected to ultrasonic treatment in water; (5), the sodium alginate solution, the bacterial cellulose homogeneous-phase suspension liquid and a silver sulfadiazine suspension liquid are mixed and prepared into a homogeneous-phase mixed liquid; the homogeneous-phase mixed liquid is poured into a die and cured with a 5% CACl2 solution, and the sodium alginate and bacterial cellulose composite antibacterial dressing loaded with silver sulfadiazine can be obtained after freeze drying. The preparation method is simple and easy to operate, the obtained composite antibacterial dressing keeps good moisture retention performance and biocompatibility, has a better inhibition function on escherichia coli, candida albicans and staphylococcus aureus and facilitates wound healing and skin regeneration, and the production process is simple.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a preparation method of a silver sulfadiazine-loaded composite antibacterial dressing. Background technique [0002] When the skin is scalded or burned due to high temperature, the wound tissue is exposed, producing pus and blood, which provides a moist living environment for bacteria, and it is difficult for the wound to heal itself. An ideal burn wound dressing should have the following characteristics: 1. It has good biocompatibility; 2. It is semi-closed or closed; 3. It can form a good water-permeable and air-permeable function on the wound; 4. It can create a wound for the wound. Slightly humid, slightly acidic, hypoxic environment. At present, the existing dressing materials in China mainly include ordinary plant fibers, carboxymethyl cellulose, and chitosan; but there are many problems such as single product types and functions, no series of products, and functional d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44A61L15/42
Inventor 邵伟刘晖王淑侠吴祭民张蕤
Owner NANJING FORESTRY UNIV
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