Otic microbial combination for treatment of animals with ruptured tympanic membrane

a technology of tympanic membrane and microbial combination, which is applied in the direction of antibacterial agents, drug compositions, biocide, etc., can solve the problems of not teaching or suggesting the use of compositions for otic applications, adverse effects such as hearing loss, and most antimicrobial compounds (e.g. aminoglycosides) have toxic effects on hair cells in the cochlea, so as to achieve the effect of safely treating animals

Inactive Publication Date: 2006-03-14
ELANCO US INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]In contrast, the present invention provides an improved composition that is useful in treating otic infections comprising an antimicrobial and silver sulfadiazine in a therapeutically effective combination to treat otic infections in animals, the improvement comprising the composition which can be used safely to treat animals with a ruptured tympani...

Problems solved by technology

However, the patent fails to teach or suggest the use of the compositions for otic applications.
Heretofore, art-known treatments of animals with a ruptured tympanic membrane produced adverse effects such as loss of hearing.
It is believed that most antimicrobial compounds (e.g. aminoglycosides) have a toxi...

Method used

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  • Otic microbial combination for treatment of animals with ruptured tympanic membrane

Examples

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example 1

[0025]

IngredientsParts By WeightEnrofloxacin0.005–1.5 Silver sulfadiazine(SSD)0.05–2.0 Polysorbate 600.5–3.5Sorbitan monostearate0.5–3.0Cetyl stearyl alcohol0.5–3.0Benzyl alcohol1.0–3.0Miglyol Oil 8–18Water89.4–68  

example 2

[0026]

IngredientsParts By WeightEnrofloxacin0.5–1.0Silver sulfadiazine(SSD)0.5–1.5Polysorbate 601.0–3.0Sorbitan monostearate1.0–2.0Cetyl stearyl alcohol1.0–2.0Benzyl alcohol1.5–2.5Miglyol Oil12–16Water85–74

example 3

[0027]

IngredientsParts By WeightEnrofloxacin0.5Silver sulfadiazine(SSD)1.0Polysorbate 602.5Sorbitan monostearate1.5Cetyl stearyl alcohol1.5Benzyl alcohol2.0Miglyol Oil14.5Water76.5

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Abstract

Disclosed herein is an improved composition that is useful in treating otic infections comprising an antimicrobial and silver sulfadiazine in a therapeutically effective combination to treat otic infections in animals, the improvement comprising the composition which can be used safely to treat animals with a ruptured tympanic membrane.

Description

[0001]This application is a continuing application of U.S. Ser. No. 09 / 669,514, filed Sep. 25, 2000, now abandoned.BACKGROUND OF THE INVENTION[0002]1. Field of Invention[0003]The present invention relates to otic formulations and antimicrobial agents and more specifically to otic formulations containing a combination of antimicrobials such as quinolones and silver sulfadiazine. More specifically, the invention relates to treatment of animals with ruptured tympanic membrane.[0004]2. Brief Description of the Prior Art[0005]U.S. Pat. No. 4,404,197 discloses the use of certain quinolones and silver sulfadiazine in treating burns. More specifically, the patent discloses compositions that include silver sulfadiazine and 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolone carboxylic acid or its metal salts, e.g., silver, zinc, cobalt or cerium salts. Distinctly, the patent teaches the use of these compositions in treating burns, and in combating topical, surface or skin infect...

Claims

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Application Information

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IPC IPC(8): A01N25/32A61K45/00A61K31/496A61K31/505A61K31/635A61K33/38A61K45/06A61P27/16A61P31/00A61P31/04
CPCA61K31/496A61K31/635A61K45/06A61K31/495A61K31/535A61K31/54A61K2300/00A61P27/16A61P31/00A61P31/04A61K33/38
Inventor CISZEWSKI, DANIEL
Owner ELANCO US INC
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