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Silver sulfadiazine film formation spray and preparation method thereof

A technology of silver sulfadiazine and film-spraying agent, which is applied in the direction of anti-inflammatory agents, pharmaceutical formulas, local antibacterial agents, etc., can solve the problems of not being able to form a mist, no literature reports, and inability to meet the spraying requirements of film-spraying agents. To achieve the effect of improving the suspension state, improving the suspension of the solution, and the effect of drainage and moisture absorption

Inactive Publication Date: 2017-12-19
南京泽恒医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polyvinyl alcohol is a commonly used water-soluble polymer film-forming material, but the inventor found that even if it is sprayed with a linear critical concentration, the spray is still linear and cannot be fogged, which cannot meet the spraying requirements of the spray film agent
Chen Zhiyuan and others have studied the comparison between chitosan spray film and sulfadiazine silver cream in the treatment of burns, but there is no literature report on the use of chitosan in sulfadiazine silver spray film

Method used

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  • Silver sulfadiazine film formation spray and preparation method thereof
  • Silver sulfadiazine film formation spray and preparation method thereof
  • Silver sulfadiazine film formation spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]

[0035] Weigh the prescription amount of sodium carboxymethylcellulose, chitosan hydrochloride and triethyl citrate, add water to dissolve, after completely dissolving, spray dry the obtained solution to obtain combined film-forming material powder; dissolve the powder In water, add methylparaben, glycerin and propylene glycol, mix well, then add silver sulfadiazine to disperse, homogenize for 30 minutes, and then fill.

Embodiment 2

[0037]

[0038] Weigh the prescription amount of sodium carboxymethylcellulose, chitosan hydrochloride and triethyl citrate, add water to dissolve, after completely dissolved, add microcrystalline cellulose, stir to disperse the microcrystalline cellulose, and obtain a suspension solution ; The obtained suspension solution is spray-dried to obtain a combined powder combining the film-forming material and the anti-sticking agent; Pyrimidine silver to make it dispersed, homogenized for 30 minutes, and then filled.

Embodiment 3

[0040]

[0041] Weigh the prescription amount of sodium carboxymethylcellulose, chitosan hydrochloride and triethyl citrate, add water to dissolve, after completely dissolved, add microcrystalline cellulose, stir to disperse the microcrystalline cellulose, and obtain a suspension solution ; The obtained suspension solution is spray-dried to obtain a combined powder combining the film-forming material and the anti-sticking agent; Pyrimidine silver to disperse it, homogenize for 20 minutes, and fill it.

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Abstract

The invention relates to a silver sulfadiazine film formation spray and a preparation method thereof. A combined film formation material is used to realize film forming and suspending aiding dual effects, so the solution suspending property of the film formation spray is improved, the spraying effect is guaranteed, the film forming performance is good, the speed is fast, and the silver sulfadiazine film formation spray is a promising silver sulphadiazine treatment dosage form.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a sulfadiazine silver film-spraying agent and a preparation method thereof. Background technique [0002] Sulfadiazine Silver (Sulfadiazine Silver) is a commonly used drug for the prevention and treatment of burn wound infection. It has a wide antibacterial spectrum and has good antibacterial activity against most Gram-positive and negative bacteria. ), and can promote wound surface dryness, incrustation and healing, and can be used to prevent and treat second-degree and third-degree burns or wound infection secondary to scalds. Although silver sulfadiazine has a good antibacterial effect, excessive local application of silver sulfadiazine can cause allergic symptoms such as irritation, transient pain, rash, dermatitis, drug fever, muscle pain, and serum sickness-like reactions. Common silver sulfadiazine dosage forms include cream, ointment, suspension, powder, etc., bu...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/635A61K31/722A61K47/38A61K47/36A61K47/14A61P17/02A61P31/02A61P31/04A61P29/00
CPCA61K9/7015A61K31/635A61K31/722A61K47/14A61K47/36A61K47/38
Inventor 张自强刘宇婧谢晓燕
Owner 南京泽恒医药技术开发有限公司
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