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Degradable medical hemostatic material and preparation method thereof

A hemostatic material and degradable technology, which is applied in the field of degradable medical hemostatic materials and their preparation, can solve the problems affecting the hemostatic performance, porosity, small specific surface area, and wide distribution range of fiber diameters of gelatin hemostatic materials, so as to improve hemostasis Performance, good biocompatibility, and the effect of improving the speed of hemostasis

Inactive Publication Date: 2019-03-01
CHTC JIAHUA NONWOVEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology involves replacing traditional organic solvent (water), called polyglycerol or hydroxypropyltrimonium salts for better compatibility with blood cells while also enhancing their effectiveness at promoting clotting time on different types of wounds. It suggests that adding these substances together could lead to improved hydrogels made from this type of polymer network dissolved in an aqueous medium without losing any beneficial qualities such as strength. Additionally, it mentions how modifying collagen by changing pH values allows for more effective use of therapeutic agents like drugs. Overall, this new method provides technical benefits over existing methods but does not involve harmful chemical compound residues.

Problems solved by technology

Technologies related to Hemostasis Materials like Gelfozy® Hemospray™ Factor Plasma Spotting Cake from Therapeutic Agents (TAP) were described earlier than other technical problem addressed during these studies due to concerns over harmful side effects caused by Tap Allophanumeric Homopolymer Beta Gluten when applied locally at different locations within the body. These issues require further improvement upon current methods involving synthetic hydrogels derived from naturally occurring sources.

Method used

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  • Degradable medical hemostatic material and preparation method thereof
  • Degradable medical hemostatic material and preparation method thereof

Examples

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Embodiment 1

[0026] A preparation method of a degradable medical hemostatic material, comprising the steps of:

[0027] (1) Preparation of mixed solvent: mix polyethylene glycol, hyaluronic acid and deionized water in a volume ratio of 1:2:10;

[0028] (2) Divide the solution of step (1) into the same three parts, then respectively add gelatin, polylactic acid and chitosan to the three parts of solvent, and stir respectively for 3 hours at a temperature of 40° C. The solutions were mixed and then stirred and ultrasonicated for 1.5 hours; wherein, the mass concentrations of gelatin, polylactic acid and chitosan in the three solutions were 8%, 1%, and 0.5% respectively;

[0029] (3) The gelatin / polylactic acid / chitosan composite superfine fiber was prepared by electrospinning the mixed solution obtained in step (2), and dried in vacuum at 80° C. for 12 hours for subsequent use; the injection rate of electrospinning was 60 μL / min, the voltage is 22KV, and the distance between the spinneret ...

Embodiment 2

[0032] A preparation method of a degradable medical hemostatic material, comprising the steps of:

[0033] (1) Preparation of mixed solvent: mix polyethylene glycol, hyaluronic acid and deionized water in a volume ratio of 2:5:15;

[0034] (2) Divide the solution of step (1) into the same three parts, then respectively add gelatin, polylactic acid and chitosan to the three parts of solvent, and stir respectively for 3 hours at a temperature of 40° C. The solutions were mixed and then stirred and ultrasonicated for 1.5 hours; wherein, the mass concentrations of gelatin, polylactic acid and chitosan in the three solutions were 7%, 1%, and 0.5% respectively;

[0035] (3) The gelatin / polylactic acid / chitosan composite microfiber was prepared by electrospinning the mixed solution obtained in step (2), and dried in vacuum at 80° C. for 12 hours for subsequent use; the injection rate of electrospinning was 60 μL / min, the voltage is 22KV, and the distance between the spinneret and t...

Embodiment 3

[0038] A preparation method of a degradable medical hemostatic material, comprising the steps of:

[0039] (1) Preparation of mixed solvent: mix polyethylene glycol, hyaluronic acid and deionized water in a volume ratio of 1:4:12;

[0040] (2) Divide the solution of step (1) into the same three parts, then respectively add gelatin, polylactic acid and chitosan to the three parts of solvent, and stir for 3 hours respectively at a temperature of 40°C, and then divide the three parts The solutions were mixed and then stirred and ultrasonicated for 1.5 hours; wherein, the mass concentrations of gelatin, polylactic acid and chitosan in the three solutions were 10%, 1%, and 0.5% respectively;

[0041] (3) The gelatin / polylactic acid / chitosan composite superfine fiber was prepared by electrospinning the mixed solution obtained in step (2), and dried in vacuum at 80° C. for 12 hours for subsequent use; the injection rate of electrospinning was 80 μL / min, the voltage is 22KV, and the...

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Abstract

The invention discloses a preparation method of a degradable medical hemostatic material. The preparation method comprises the following steps: (1) mixing polyethylene glycol, hyaluronic acid and deionized water according to a certain volume ratio; (2) dividing the solution in the step (1) into three parts which are identical, then adding gelatin, polylactic acid and chitosan to the three parts ofthe solution separately and stirring, and then stirring and sonicating the three parts of the solution; (3) carrying out electrospinning on the mixed solution obtained in the step (2) to obtain gelatin/polylactic acid/chitosan composite ultrafine fiber, and vacuum drying the fiber; (4) adding the ultrafine fiber obtained in the step (3) to a solution of silver sulfadiazine for soaking, then freeze drying the fiber, and hot pressing the fiber on a hot pressing plate to obtain the degradable medical hemostatic material. The raw materials used in the hemostatic material are all harmless raw materials with good biocompatibility and biodegradability, have good bioadhesion, can well control the continuous bleeding of the tissue, and have high hemostatic capacity.

Description

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Claims

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Application Information

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Owner CHTC JIAHUA NONWOVEN CO LTD
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