181 results about "Diabetic foot ulcer" patented technology

An orthopedic walking boot promotes rapid healing of diabetic foot ulcerations by lowering the maximum peak pressure imposed upon the foot. The walker has a hard unyielding shell which is designed for walking. The shell closely and rigidly supports a mid-sole in a foot-shaped bed. The mid-sole has a foot-shaped cavity with rounded sides adapted to form resilient support for the heel, arch and sides of a foot in addition to the bottom of a foot. A conformable inner-sole is adapted to fit over the foot-shaped cavity in the mid-sole and be compressed in response to foot pressure between the sides and bottom of the foot and the sides and bottom of the foot-shaped cavity in the mid-sole thereby compensating for small differences between the shape of the foot and the shape of the cavity. Weight applied to the foot is transferred to the walking shell by contact between the sides of the foot, arch, and heel and the arch, heel and sides of the foot-shaped cavity as well as the bottom of the cavity thereby decreasing the peak or maximum unit pressure on the plantar surface of the foot. A breathable bootie which wraps the foot and lower leg in a protective “cocoon” is preferably secured to the upper surface of the insole thereby preventing foreign materials from entering the foot cavity.

The present invention describes novel methods for using 9-deoxy-2′,9-α-methano-3-oxa-4,5,6-trinor-3,7-(1′,3′-interphenylene)-13,14-dihydro-prostaglandin F₁ (also known as Treprostinil) or its derivative, or a pharmaceutically acceptable salt thereof, for the treatment and/or prevention of foot ulcers in subjects with diabetic neuropathy. The invention also relates to kits for treatment and/or prevention of foot ulcers, comprising an effective amount of Treprostinil or its derivative, or a pharmaceutically acceptable salt thereof.

The wound assessing method and system of the present teachings provide a convenient, quantitative mechanism for diabetic foot ulcer assessment.

The wound assessing method and system provide a convenient, quantitative mechanism for diabetic foot ulcer assessment.

The present invention is related to a pharmaceutical composition comprising snail slime of Helix aspersa müller (Cryptophalus aspersus) (5% to 50%) and marigold extract, propolis and/or almond oil and pharmacologically accepted additives for the prevention additives and/or pharmaceutically acceptable excipients to form a formulation of intermediate to high viscosity (200 to 1000 Pa-s). This invention also relates to the use of a composition which can be formed as a cream or a gel, is preferably soaked in gauze, and shaped as a bandage or sock for the treatment and cure of diabetic foot ulcers and other severe wounds, particularly those associated with diabetes, gout, Lesch Nyhan syndrome or other conditions to the skin, including, keratosis, onychomycosis, ringworm, among others.

The invention provides a foot tub special for a diabetic patient. The foot tub comprises an outer tub and an inner tub. The inner tub is arranged inside the outer tub through a spiral height adjusting mechanism. A vibration spring is arranged between tub bottoms of the outer tub and the inner tub. A vibration original piece is arranged at the bottom of the outer side of the inner tub. A stretchable strut is installed on the outer side wall of the outer tub. A magnifying lens is arranged on a handheld handle of the stretchable strut. A sponge tip is arranged at the tail end of the stretchable strut. The two outer side walls of the outer tub are provided with inspectoscopes in a hinged mode. Supporting feet are fixedly installed below the inspectoscopes. A water thermometer is arranged on the inner side wall of the inner tub. A temperature alarm device is arranged between the outer tub and the inner tub and connected with the water thermometer. The foot phenomenon can be conveniently inspected during a foot bath of the patient, the inducements such as the water temperature of the foot bath, the foot soaking time and scrubbing with strength which are likely to damage the feet of the diabetic patient are limited, diabetic feet can be prevented and found easily while the diabetic patient has a comfort foot bath, traditional Chinese medicine compositions are combined, the treatment effect reaches 95%, and the foot tub is safe, comfortable and quite good in effect.

The invention provides an MG53 (mitsugumin53) mutant and a preparation method thereof. The mutant is a serine-site mutant of MG53 protein in a Coiled-coil structural domain, and the mutant results in inactivation of MG53 phosphorylation. Meanwhile, the MG53 protein mutant can be used for preventing or treating diseases related to cellular membrane damage, such as diseases related to myocardial cell injury, diseases related to ulcer, trauma with a wound, particularly a difficult-to-heal wound, intestinal leakage, kidney injury and the like. The diseases related to myocardial cell injury can include one or more diseases related to following symptoms: myocardial ischemia, heart ischemia, heart ischemia/reperfusion injury, myocardial infarction, cardiac failure, arrhythmia and cardiac rupture. The diseases related to ulcer include one or more of following diseases: chronic ulcer, peptic ulcer, diabetic foot ulcer, diabetic foot gangrene and chronic gastric ulcer. Besides, the invention further provides a dry powder preparation, a spray preparation, a gel preparation and an emulsion containing MG53 or MG53 mutant as well as preparation methods of the preparations.

A diabetic foot ulcer (DFU) classification method proposed in the invention based on a convolutional neural network includes the steps of creating a DFU data set, marking a region of interest (ROI), adding data, pre-processing training patches, conventional machine learning, and constructing a DFU network. The process includes: first collecting foot images of a DFU patient and a healthy person asdata sets and plotting ROIs, then adding data using a combination of various image processing techniques for network training, next, pre-processing the obtained patches, normalizing each pixel, and finally constructing a DFU network including input data, parallel convolutions, a fully connected layer, and an output classifier. The method of the invention utilizes an advanced convolutional neural network to process the input data more effectively and efficiently; and has high sensitivity and can effectively distinguish the characteristic differences between the healthy skin and the DFU, therebygreatly shortening the processing time.

The invention provides Chinese medicinal detoxifying myo-regeneration paste for treating diabetic foot ulcer, which belongs to the fields of traditional Chinese medical science and traditional Chinese medicines. The paste is prepared from the following raw materials in percentage by weight: 6 to 11 percent of rhubarb, 6 to 11 percent of golden thread, 6 to 11 percent of amur corktree bark, 14 to 19 percent of plaster, 12 to 17 percent of sinkiang arnebia root, 14 to 20 percent of Chinese angelica, 7 to 11 percent of angelica dahurica, 2 to 5 percent of calomel, 7 to 11 percent of dragon's blood and 23 to 30 percent of bee wax. Animal experiments and clinical researches prove that the Chinese medicinal detoxifying myo-regeneration paste provided by the invention has the effects of activating blood, dissolving stasis, removing putrefaction, regenerating myo, clearing away heat and toxic material and the like, has the advantages of keeping the surface of a wound wet, increasing the content of cell factors, namely, a vascular endothelial growth factor (VEGF) and a platelet-derived growth factor (PDGF) and promoting relevant gene expressions of muscles and blood vessels, along with definite curative effect, simple and convenient operation, economy, safety and no toxic or side effect and special significance in treating diabetic foot ulcer.

A system and method for facilitating the healing of a skin ulcer, such as a diabetic ulcer, on a treatment region of a body. Ultrasound waves are transmitted to the treatment region. Interferential electrical stimulation is applied to the treatment region, simultaneously with the ultrasound transmission. The treatment region may be massaged with a massaging device during the treatment session. A gel may be applied onto the treatment region to facilitate the ultrasound transmission and electrical stimulation. A measurement system may be used to obtain accurate measurements of the skin ulcer, to provide a quantitative determination of the healing progression.

The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.

The present invention provides methods and pharmaceutical formulations for treating diabetic foot ulcers.

A synergistic pharmaceutical composition for the preparation of topical formulations for use in prophylaxis and treatment of wounds, burn wounds, skin grafts, pressure ulcers, diabetic foot ulcers and other skin diseases is provided. The composition may include one or more synergistically active ingredients and one or more inactive ingredients. The synergistically active ingredients may include Recombinant Human Epidermal Growth Factor (rh-EGF) (REGEN-D™ of Bharat Biotech International Limited) and/or Platelet Derived Growth Factor (rh-PDGF-BB), silver sulfadiazine (SSD) and chlorhexidine gluconate (CHG). One or more inactive ingredients may comprise carriers, preservatives, emulsifiers, skin emollients and soothers and one or more other constituents.

The invention discloses bioactive functional dressing for treating diabetic feet. The dressing comprises a bioactive functional layer, an antibacterial functional layer, a fluid absorption functional layer and a biotic pressure functional layer sequentially from the bottom up. The dressing is simple in structure and low in production expense, low in cost and convenient to operate at the same time, greatly facilitates treatment of diabetic foot wounds of a doctor and medical care personnel; an active ingredient of the bioactive functional layer has a slow release effect; the dress can effectively stimulate and promote cell activation and regeneration of the surfaces of the diabetic foot wounds and promotes capillary network and nerve repair of the surfaces of the wounds by the action of the biological active ingredient. The dressing has effects of repairing neural and vascular lesions, efficiently resisting infection, absorbing fluid and evacuating pus on the surfaces of the wounds, and a biomechanical effect on the wounds, is multifunctional and good in treatment effect and can be widely applied to clinical treatment and nursing of the diabetic feet.