Fast restoration liquid for burn and scald injury and preparation method thereof

A burn and repair liquid technology, applied in the biological field, can solve the problems of cell number and expansion, the decline of differentiation ability, and not suitable for batch preparation, so as to improve the physiological activity and metabolism level, enhance immunity and self-repair ability, Promotes growth and renewal

Inactive Publication Date: 2018-09-18
伯仕利生物科技发展(盐城)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bone marrow-derived mesenchymal stem cells are not suitable for batch production due to the hidden danger of virus contamination, and as the age of the donor increases, the number of cells and the ability to expand and differentiate will decline significantly.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] A quick repair liquid for burns and scalds, comprising a culture supernatant containing epidermal cell growth factor, human keratinocyte growth factor, human fibroblast growth factor, human platelet-like derived growth factor and fibronectin stem cells.

[0029] The concentration of the culture supernatant is greater than or equal to 1×10 10 Pcs / ml.

[0030] An application of a quick repair liquid for burns and scalds in the repair treatment of burns and scalds patients and ulcers that have not healed for a long time.

[0031] An application of a quick repair liquid for burns and scalds in traumatic wounds and preventing scar formation.

[0032] A method for preparing a quick repair solution for burns and scalds, including the following steps:

[0033] ⑴. Isolation of conventional mesenchymal stem cells to obtain mesenchymal stem cells;

[0034] Taking the isolation of human umbilical cord mesenchymal cells as an example, the modified tissue block adherence method was used to prep...

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PUM

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Abstract

The invention relates to fast restoration liquid for burn and scald injury and a preparation method thereof. Stem cells obtained through conventional separation are used; human fibronectin (FN) is subjected to overexpression by a molecular clone technology; the stem cells richly containing various autocrine cell factors and overexpression FN are used for culturing supernatant; the obtained restoration liquid is applied to the restoration treatment on burn and scald injury patients and severe and lingering ulceration wounds. The method is simple and convenient; the implementation is easy; the fast restoration liquid is applicable to the large-scale production of stem cell culture supernatants with different sources. In addition, the kinds of products are applied to the restoration treatmentof burn and scald injury patients and severe and lingering ulceration wounds. A novel path is provided for the application of the stem cells in medical conversion career.

Description

Technical field [0001] The invention belongs to the field of biotechnology and relates to a quick repair liquid for burns and scalds and a preparation method thereof. Background technique [0002] Studies have reported that severe trauma, extensive burns, and wound coverage after plastic surgery have become a very important issue. In addition to patient autologous skin grafts, people have used allogeneic skin grafts and other related repair materials to cover the wounds, but Both autologous or allogeneic skin transplantation are limited by the source of the donor and immune rejection. It is urgent to find an ideal natural medicine that has no rejection reaction, promotes skin damage repair, and promotes skin regeneration. [0003] Stem cells have unique differentiation potential, can heal tissues that are difficult to heal by themselves, and can treat clinically incurable diseases. Stem cells are early undifferentiated cells with self-replication and multi-differentiation potentia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P17/02A61K38/18
CPCA61K9/0014A61K38/18A61K38/1808A61K38/1825A61K38/1858A61K38/39A61P17/02A61K2300/00
Inventor 吴金芸叶华衍
Owner 伯仕利生物科技发展(盐城)有限公司
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