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36 results about "Incurable diseases" patented technology

List of incurable diseases. Jump to navigation Jump to search. This is an incomplete list of incurable diseases. It includes both physical and mental diseases. A. Allergic diseases – Allergies, or Allergic diseases, are conditions in which ...

Inducible System for Highly Efficient Production of Recombinant Adeno-Associated Virus (rAAV) Vectors

Production of clinical grade gene therapy vectors for human trials remains a major hurdle in advancing cures for a number of otherwise incurable diseases. Disclosed herein are systems based on a stably trans formed insect cell lines harboring helper genes required for vector production. Specifically exemplified are system embodiments that take advantage of DNA regulatory elements from two unrelated viruses—AcMNPV and AA V2. System embodiments utilize rep and / or cap genes either stably transfected in cell lines or which are introduced into cells as an expression cassette in a vector. Rep and cap genes that are designed to remain silent until the cell is infected with a viral vector. Infection with viral initiates rescue / amplification of integrated AAV helper genes resulting in dramatic induction of the expression and assembly of rAAV. The arrangement of this specific embodiment provides high levels of Rep and Cap proteins in every cell thus improving rAAV yields by 10-fold. The described vectors are modular in design and may be utilized for the production of other multiprotein complexes.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof

Disclosed is a conjugate for gene transfer, which is capable of being used for treatment of incurable diseases, comprising an oligonucleotide intended to be transferred into target cells and a hydrophilic polymer, wherein an end of the oligonucleotide is covalently conjugated to the hydrophilic polymer. Also, the present invention discloses polyelectrolyte complex micelles formed from such a conjugate and a cationic polymer or cationic peptide. Such polyelectrolyte complex micelles can effectively transfer oligonucleotides as therapeutic agents into target cells, making it possible to obtain desired activities of the delivered oligonucleotides in target cells even when the micelles are clinically applied at a relatively low concentration. Therefore, the conjugate and the polyelectrolyte complex micelle are very useful in basic life science research and the medical field.
Owner:BIONEER CORP 33 3 +3

Physical therapy apparatus for integrating sound, light electric, magnetic, heat, medicinal and mechanical treatment method into one capable of inducing and removing obstruction in channels and its pr

InactiveCN1206975CGood choiceGet through fast and comprehensiveUltrasound therapyElectrotherapyIncurable diseasesDisease
The physical therapy instrument that integrates acousto-optic, electromagnetic, heat, and medicinal therapy and induces meridians belongs to the comprehensive field of using sound, light, electricity, magnetism, heat, massage, drug iontophoresis and audio and video special effects to induce meridians. A variety of energies and technologies combined with the environment, receptors and their consciousness constitute a large system to maximize the potential and immune function of the receptors themselves. According to the characteristics of the receptors, these energies or technologies can be selected individually, multiplely or comprehensively, and act on the receptors separately or simultaneously, locally or comprehensively, statically or dynamically, so as to achieve adjustment, induction and treatment, until the meridians of the whole body are opened up, and then The meridians can be operated without the aid of instruments, so as to achieve the purpose of strengthening the brain, strengthening the body, and prolonging life. It can be used for psychological quality training and physical recovery of mentally stressed persons or athletes, and it can be used for the adjustment of various physiological systems of the recipient.
Owner:沈来沛

System based on TCM syndrome differentiation artificial neural network algorithm model

ActiveCN107016438AStrengthen the ability of dialectical classificationImprove efficiencyDiagnostic recording/measuringSensorsIncurable diseasesFlavor
The invention discloses a system based on a TCM syndrome differentiation artificial neural network algorithm model, which can enhance the syndrome differentiation classification capability of different dominant diseases, improve the efficiency and accuracy of TCM syndrome differentiation diagnosis and treatment, can expand the scope of treated diseases of TCM doctors, improve the diagnosis and treatment capability of incurable diseases, and shorten the clinical experience accumulation time of young TCM doctors. The system includes a symptom input layer module for receiving the input patient disease data; a first hidden layer module for performing quantization coding of the input disease data; a second hidden layer module for performing correlation function calculation according to the quantization coding of the disease data to obtain the corresponding disease cause, disease location, disease nature and disease characteristic classification; and a syndrome-type output layer module for outputting the result data of the symptom and the corresponding syndrome type when the coincidence of the disease cause, disease location, disease nature and disease characteristic of the disease and the nature and flavor characteristic of the medicinal material is higher than the preset threshold.
Owner:CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE

Nanoparticle sensor for measuring protease activity and method for manufacturing the same

Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.
Owner:KOREA INST OF SCI & TECH +2

Pharmaceutical compositions and articles of manufacture useful in reversal of a clinical epiosode of an incurable disease and methods of use thereof

A method of reversing a clinical episode of a disease which is generally considered incurable in a subject. The method includes providing an immune-globulin preparation containing a detectable titre of antibodies to the disease which is generally considered incurable and administering the immune-globulin preparation to the subject. Preferably, the immune globulin preparation is a pool of immune globulin fractions gathered from blood of donors living in an area where the disease is endemic. Further disclosed are pharmaceutical compositions and articles of manufacture suited for use in practice of the method.
Owner:SANZ MEDICAL CENT LANIADO HOSPITAL

Pharmaceutical compositions and articles of manufacture useful in reversal of a clinical epiosode of an incurable disease and methods of use thereof

A method of reversing a clinical episode of a disease which is generally considered incurable in a subject. The method includes providing an immune-globulin preparation containing a detectable titre of antibodies to the disease which is generally considered incurable and administering the immune-globulin preparation to the subject. Preferably, the immune globulin preparation is a pool of immune globulin fractions gathered from blood of donors living in an area where the disease is endemic. Further disclosed are pharmaceutical compositions and articles of manufacture suited for use in practice of the method.
Owner:SANZ MEDICAL CENT LANIADO HOSPITAL

Cloud clinic grading diagnosis and treatment management platform

PendingCN107103570ARealization of graded diagnosis and treatmentData processing applicationsIncurable diseasesTreatment management
The invention relates to a cloud clinic grading diagnosis and treatment management platform, including a cloud clinic service client, a personal client, a community data transmission terminal, an incurable disease transmission terminal, a medical data transmission terminal, a referral data transmission terminal, a consultation client and a grading diagnosis and treatment terminal. The platform utilizes the cloud clinic diagnosis and treatment integral solution scheme which enhances the offline basic detection terminal, utilizes online Internet technologies to establish the cloud clinic service terminal including the cloud clinic diagnosis and treatment management platform and the cloud clinic remote assisted clinic platform, the family doctor platform, the WeChat and other Internet platforms, combines the superior hospital professional physician resources, and ultimately achieves organic integration and interconnection of the hospital and community center medical resources, , to achieve the grading diagnosis and treatment integral solution scheme of primary diagnosis, two-way referral, acute chronic division, upper and lower linkage solution.
Owner:苏州云诊医疗科技有限公司

Nanoparticle sensor for measuring protease activity and method for manufacturing the same

Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.
Owner:KOREA INST OF SCI & TECH +2

Ionic complex nanoparticles for detecting heparanase activities and method for preparing the same

Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases. Accordingly, the ionic complex nanoparticles for detecting heparanase activities may be effectively used to early diagnose various diseases and incurable diseases including autoimmune diseases such as cancers, osteoarthritis, rheumatoid arthritis, and dementia.
Owner:KOREA INST OF SCI & TECH

Multipotent adult stem cells having an ability of oct4 expression derived from umbilical cord blood and method for preparing the same

InactiveUS20090305413A1Negative immunological responseBlood/immune system cellsCell culture active agentsGerm layerDisease
The present invention relates to multipotent adult stem cells expressing Oct4, derived from umbilical cord blood (UCB) and also these cell are expressing CD29, CD31, CD44, simultaneously, a method for preparing the same, and more specifically to multipotent adult stem cells which are obtained by culturing umbilical cord blood-derived monocytes in a medium containing bFGF (basic fibroblast growth factor) and human serum or plasma. In addition, multipotent adult stem cells expressing Oct-4 from UCB are morphologically spindle or round shaped cells Although the stem cells according to the present invention are adult stem cells, they are multipotent and capable of differentiating into ectodermal-, messodermal-, endodermal-originated tissue or cells including osteogenic cells or nerve cells etc, thus they can be effectively used in the treatment of intractable diseases and incurable diseases.
Owner:SEOUL NAT UNIV R&DB FOUND

New method for preventing and controlling fruit mulberry sclerotiniose without causing pesticide residue

ActiveCN104871882AReduce manufacturing costThorough prevention and treatment effectHorticulture methodsPlant protectionDiseaseIncurable diseases
The invention provides a new method for preventing and controlling fruit mulberry sclerotiniose without causing pesticide residue. According to different phonological areas of fruit mulberry planting areas or changes of small climate such as temperature and humidity and surrounding disease source environments, in combination with comprehensive situations such as the lowest winter temperature in the previous year, specific forms of fruit mulberry blooming stages are artificially divided into three stages, so as to thoroughly prevent and control the incurable disease, i.e., the fruit mulberry sclerotiniose by using the existing bactericides in a certain time span at a specific blooming stage without using special pesticide and guarantee that mature mulberry fruits are free of pesticide residue. The new method has a very great application value.
Owner:屈恩勤

Toothpaste for preventing gum from apolexis and oxidization and preparation thereof

The invention relates to toothpaste which is made from Euonymus fortunei, ginseng, angelica, sapanwood, gromwell extracting solution, lightweight calcium carbonate, carboxymethyl cellulose, glycerol, spice, sodium dodecyl sulfate, saccharin sodium, preservative and distilled water. The preparation method is that, respectively preparing the traditional Chinese medicines of fortunei, ginseng, angelica, sapanwood, gromwell extracting solution, the carboxymethyl cellulose solution and the traditional Chinese medicine complex liquid; then mixing the carboxymethyl cellulose solution with the traditional Chinese medicine complex liquid, and then mixing the mixture with the lightweight calcium carbonate, grinding the mixture into thin cream via a three steel sword machine, putting the thin cream into the seal of the toothpaste tube via a cream percussion machine. The invention belongs to the toothpaste which is extracted from wild medicinal plants and can effectively cure atrophy; the toothpaste touches the dental face via a toothbrush, stimulates the blood flow, makes the gum absorb nutrition directly, and effectively cures the incurable disease of gum atrophy. The toothpaste can make the atrophied gum regenerate and expand to cover the loose tooth tightly, and is beneficial to keep the peridentalt healthy.
Owner:李浪辉

Ionic complex nanoparticles for detecting heparanase activities and method for preparing the same

Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases. Accordingly, the ionic complex nanoparticles for detecting heparanase activities may be effectively used to early diagnose various diseases and incurable diseases including autoimmune diseases such as cancers, osteoarthritis, rheumatoid arthritis, and dementia.
Owner:KOREA INST OF SCI & TECH

Traditional Chinese medicine composition used for treating ulcerative colitis

The invention relates to a traditional Chinese medicine composition used for treating ulcerative colitis. Ulcerative colitis (UC) is an inflammatory disease happening at colon and rectum parts. The causes of UC are complicated, and UC is one of clinical incurable diseases. The disease is caused by intrinsic dampness. Evils of dampness and heat toxin attack the intestines, and a struggle is held between the vital energy and the evils. Under the struggle, even intestinal mucosa carbuncle ulcers are caused. Aiming at the problem, the medicine composition provided by the invention adopts traditional Chinese medicines with heat clearing, dampness eliminating, and pain prioritizing functions, such as large angiopteris rhizome, dandelion, medicinal fatheadtree stem and bark, ash bark, wilson barberry root, largehead atractylodes rhizome, red peony root, hispid Chinese knotweed root, rhubarb, and tsao-ko amomum fruit. The traditional Chinese medicines are prepared into an enema. As a result of clinical experiments in our hospital, a total effective rate reaches 96.7%. The total effective rate and clinical improvement conditions are better than a control group. Therefore, the traditional Chinese medicine composition is worthy of clinical application.
Owner:刘文生

Bio-organic fertilizer and application thereof

The invention provides a bio-organic fertilizer containing composite inocula, which belongs to the technical field of a bio-organic fertilizer. The bio-organic fertilizer comprises the following raw materials in parts by weight: 20-40 parts of the composite inocula, 20-30 parts of pepper cake, 1-3 parts of corn flour, 1-3 parts of wheat bran, 10-20 parts of meat and bone meal, 1-3 parts of medicalstone, 5-15 parts of rice bran, and 12-20 parts of humic acid; the pH value of the bio-organic fertilizer is 5.5-5.8; the composite inocula comprises lactobacillus rhamnosus, bacillus subtilis, microzyme and photosynthetic bacteria; and the total effective bacteria amount in the composite inocula is greater than or equal to 1*10<8> cfu / g. The bio-organic fertilizer of the invention can improve the soil environment, can improve the agglomerate structure of the soil, loosen and breathe the soil, break soil hardening, and reduce the moss, satisfy crop demand for the fertilizer, and stimulate crop growth, and successfully solve the premature aging, nematode and dead trees and other incurable diseases caused by continuous-cropping of soil.
Owner:郭春灵

Pharmaceutical compositions and articles of manufacture useful in reversal of a clinical epiosode of an incurable disease and methods of use thereof

A method of reversing a clinical episode of a disease which is generally considered incurable in a subject. The method includes providing an immune-globulin preparation containing a detectable titre of antibodies to the disease which is generally considered incurable and administering the immune-globulin preparation to the subject. Preferably, the immune globulin preparation is a pool of immune globulin fractions gathered from blood of donors living in an area where the disease is endemic. Further disclosed are pharmaceutical compositions and articles of manufacture suited for use in practice of the method.
Owner:SANZ MEDICAL CENT LANIADO HOSPITAL

Copper (1) Complex

Copper (I) chloride complex of pyrazinic acid is prepared, characterized by elemental analysis, IR, UV-visible spectra and its crystal structure determined by single crystal diffraction methods. This compound is found to exhibit a very positive influence as a drug, in a pharmaceutical acceptable composition for different incurable diseases, e.g. myopathy or weakness of muscles in general, infertility, and certain genetically causes disorders in mammals. These products were found to improve symptoms of myopathy, male infertility, fatigue and weakness of muscles for different reasons, and certain genetically causes disorders in mammals. It also enhanced regeneration of tissue affected by skin burns, scars, improved alopecia, decreased blood lipids and helped in loss of weight in obese patients. The observed wide scope of activities probably due to stem cell stimulation, enhancement the immune system and role of copper dependent enzyme activity.
Owner:HUSSEIN SALAH FATHI +2

Multipotent adult stem cell derived from canine umbilical cord blood, placenta and canine fetus heart, method for preparing the same and cellular therapeutics containing the same

InactiveUS20100021436A1Remarkable cell growthBiocideMammal material medical ingredientsIncurable diseasesDisease
The present invention relates to multipotent adult stem cells derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart, and a method for preparing the same as well as a cellular therapeutic agent containing the same, more specifically, to a multipotent adult stem cell isolated by culturing an eukaryotic cell derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart in a FBS-containing medium and a method for preparing the same. Adult stem cells according to the present invention are derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart. The adult stem cells have characteristics highly similar to human mesenchymal stem cells as well as remarkable cell growth at the initial step compared to human UCB-derived mesenchymal stem cells so that the cells are useful to treat canine incurable diseases and difficult-to-cure diseases. Furthermore, multipotent adult stem cells are effective to treat musculoskeletal diseases and neural diseases due to the ability to differentiate into osteogenic cells and neural cells.
Owner:SEOUL NAT UNIV R&DB FOUND

Multipotent adult stem cells having an ability of Oct4 expression derived from umbilical cord blood and method for preparing the same

The present invention relates to multipotent adult stem cells expressing Oct4, derived from umbilical cord blood (UCB) and also these cell are expressing CD29, CD31, CD44, simultaneously, a method for preparing the same, and more specifically to multipotent adult stem cells which are obtained by culturing umbilical cord blood-derived monocytes in a medium containing bFGF (basic fibroblast growth factor) and human serum or plasma. In addition, multipotent adult stem cells expressing Oct-4 from UCB are morphologically spindle or round shaped cells Although the stem cells according to the present invention are adult stem cells, they are multipotent and capable of differentiating into ectodermal-, messodermal-, emdodermal-originated tissue or cells including osteogenic cells or nerve cells etc, thus they can be effectively used in the treatment of intractable diseases and incurable diseases.
Owner:SEOUL NAT UNIV R&DB FOUND

Toothpaste for preventing gum from apolexis and oxidization and preparation thereof

The invention relates to toothpaste which is made from Euonymus fortunei, ginseng, angelica, sapanwood, gromwell extracting solution, lightweight calcium carbonate, carboxymethyl cellulose, glycerol, spice, sodium dodecyl sulfate, saccharin sodium, preservative and distilled water. The preparation method is that, respectively preparing the traditional Chinese medicines of fortunei, ginseng, angelica, sapanwood, gromwell extracting solution, the carboxymethyl cellulose solution and the traditional Chinese medicine complex liquid; then mixing the carboxymethyl cellulose solution with the traditional Chinese medicine complex liquid, and then mixing the mixture with the lightweight calcium carbonate, grinding the mixture into thin cream via a three steel sword machine, putting the thin cream into the seal of the toothpaste tube via a cream percussion machine. The invention belongs to the toothpaste which is extracted from wild medicinal plants and can effectively cure atrophy; the toothpaste touches the dental face via a toothbrush, stimulates the blood flow, makes the gum absorb nutrition directly, and effectively cures the incurable disease of gum atrophy. The toothpaste can make the atrophied gum regenerate and expand to cover the loose tooth tightly, and is beneficial to keep the peridentalt healthy.
Owner:李浪辉

Traditional Chinese medicine composition used for treating ulcerative colitis

The invention relates to a traditional Chinese medicine composition used for treating ulcerative colitis. Ulcerative colitis (UC) is an inflammatory disease happening at colon and rectum parts. The causes of UC are complicated, and UC is one of clinical incurable diseases. The disease is caused by intrinsic dampness. Evils of dampness and heat toxin attack the intestines, and a struggle is held between the vital energy and the evils. Under the struggle, even intestinal mucosa carbuncle ulcers are caused. Aiming at the problem, the medicine composition provided by the invention adopts traditional Chinese medicines with heat clearing, dampness eliminating, and pain prioritizing functions, such as large angiopteris rhizome, dandelion, medicinal fatheadtree stem and bark, ash bark, wilson barberry root, largehead atractylodes rhizome, red peony root, hispid Chinese knotweed root, rhubarb, and tsao-ko amomum fruit. The traditional Chinese medicines are prepared into an enema. As a result of clinical experiments in our hospital, a total effective rate reaches 96.7%. The total effective rate and clinical improvement conditions are better than a control group. Therefore, the traditional Chinese medicine composition is worthy of clinical application.
Owner:刘文生

Formula for treating multiple incurable diseases

The invention discloses a formula for treating multiple incurable diseases. The formula comprises the following components by weight: folium artemisiae argyi, sulphur, frankincense, musk, fructus gleditsiae abnormalis, fructus aurantii, rhizoma chuanxiong, cassia twig, cortex eucommiae, scorpion, radix angelicae dahurioae, herba asari, rosin, realgar, radix angelicae pubescentis, squama manitis, clove, safflower, herba taraxaci, herba hedyotidis diffusae, herba scutellariae barbatae, flos rosae rugosae, herba lobeliae chinensis, red paeony root, caulis bambusae in taeniam, radix clematidis, folium perillae, radix bupleuri and rhizoma corydalis. The formula is simple in proportion and convenient to use; the red paeony root is slightly cold in property and bitter in taste, belongs to the liver meridian and the stomach meridian, and has the effects of clearing heat and removing toxicity as well as cooling blood and relieving sore-throat; a medicine prepared according to the formula is high in permeability, material-saving and high in medicinal value, can directly arrive at the focus, and can be used for treating the multiple diseases such as arthralgia, impotence, epilepsy, asthma and tumors.
Owner:杨建华
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