35 results about "Incurable diseases" patented technology

Production of clinical grade gene therapy vectors for human trials remains a major hurdle in advancing cures for a number of otherwise incurable diseases. Disclosed herein are systems based on a stably trans formed insect cell lines harboring helper genes required for vector production. Specifically exemplified are system embodiments that take advantage of DNA regulatory elements from two unrelated viruses—AcMNPV and AA V2. System embodiments utilize rep and/or cap genes either stably transfected in cell lines or which are introduced into cells as an expression cassette in a vector. Rep and cap genes that are designed to remain silent until the cell is infected with a viral vector. Infection with viral initiates rescue/amplification of integrated AAV helper genes resulting in dramatic induction of the expression and assembly of rAAV. The arrangement of this specific embodiment provides high levels of Rep and Cap proteins in every cell thus improving rAAV yields by 10-fold. The described vectors are modular in design and may be utilized for the production of other multiprotein complexes.

Disclosed is a conjugate for gene transfer, which is capable of being used for treatment of incurable diseases, comprising an oligonucleotide intended to be transferred into target cells and a hydrophilic polymer, wherein an end of the oligonucleotide is covalently conjugated to the hydrophilic polymer. Also, the present invention discloses polyelectrolyte complex micelles formed from such a conjugate and a cationic polymer or cationic peptide. Such polyelectrolyte complex micelles can effectively transfer oligonucleotides as therapeutic agents into target cells, making it possible to obtain desired activities of the delivered oligonucleotides in target cells even when the micelles are clinically applied at a relatively low concentration. Therefore, the conjugate and the polyelectrolyte complex micelle are very useful in basic life science research and the medical field.

The invention discloses a system based on a TCM syndrome differentiation artificial neural network algorithm model, which can enhance the syndrome differentiation classification capability of different dominant diseases, improve the efficiency and accuracy of TCM syndrome differentiation diagnosis and treatment, can expand the scope of treated diseases of TCM doctors, improve the diagnosis and treatment capability of incurable diseases, and shorten the clinical experience accumulation time of young TCM doctors. The system includes a symptom input layer module for receiving the input patient disease data; a first hidden layer module for performing quantization coding of the input disease data; a second hidden layer module for performing correlation function calculation according to the quantization coding of the disease data to obtain the corresponding disease cause, disease location, disease nature and disease characteristic classification; and a syndrome-type output layer module for outputting the result data of the symptom and the corresponding syndrome type when the coincidence of the disease cause, disease location, disease nature and disease characteristic of the disease and the nature and flavor characteristic of the medicinal material is higher than the preset threshold.

The invention relates to a cloud clinic grading diagnosis and treatment management platform, including a cloud clinic service client, a personal client, a community data transmission terminal, an incurable disease transmission terminal, a medical data transmission terminal, a referral data transmission terminal, a consultation client and a grading diagnosis and treatment terminal. The platform utilizes the cloud clinic diagnosis and treatment integral solution scheme which enhances the offline basic detection terminal, utilizes online Internet technologies to establish the cloud clinic service terminal including the cloud clinic diagnosis and treatment management platform and the cloud clinic remote assisted clinic platform, the family doctor platform, the WeChat and other Internet platforms, combines the superior hospital professional physician resources, and ultimately achieves organic integration and interconnection of the hospital and community center medical resources, , to achieve the grading diagnosis and treatment integral solution scheme of primary diagnosis, two-way referral, acute chronic division, upper and lower linkage solution.

The present invention relates to multipotent adult stem cells expressing Oct4, derived from umbilical cord blood (UCB) and also these cell are expressing CD29, CD31, CD44, simultaneously, a method for preparing the same, and more specifically to multipotent adult stem cells which are obtained by culturing umbilical cord blood-derived monocytes in a medium containing bFGF (basic fibroblast growth factor) and human serum or plasma. In addition, multipotent adult stem cells expressing Oct-4 from UCB are morphologically spindle or round shaped cells Although the stem cells according to the present invention are adult stem cells, they are multipotent and capable of differentiating into ectodermal-, messodermal-, endodermal-originated tissue or cells including osteogenic cells or nerve cells etc, thus they can be effectively used in the treatment of intractable diseases and incurable diseases.

The invention relates to toothpaste which is made from Euonymus fortunei, ginseng, angelica, sapanwood, gromwell extracting solution, lightweight calcium carbonate, carboxymethyl cellulose, glycerol, spice, sodium dodecyl sulfate, saccharin sodium, preservative and distilled water. The preparation method is that, respectively preparing the traditional Chinese medicines of fortunei, ginseng, angelica, sapanwood, gromwell extracting solution, the carboxymethyl cellulose solution and the traditional Chinese medicine complex liquid; then mixing the carboxymethyl cellulose solution with the traditional Chinese medicine complex liquid, and then mixing the mixture with the lightweight calcium carbonate, grinding the mixture into thin cream via a three steel sword machine, putting the thin cream into the seal of the toothpaste tube via a cream percussion machine. The invention belongs to the toothpaste which is extracted from wild medicinal plants and can effectively cure atrophy; the toothpaste touches the dental face via a toothbrush, stimulates the blood flow, makes the gum absorb nutrition directly, and effectively cures the incurable disease of gum atrophy. The toothpaste can make the atrophied gum regenerate and expand to cover the loose tooth tightly, and is beneficial to keep the peridentalt healthy.

Provided is a method for producing mesenchymal stem cells from human pluripotent stem cells, the method including: a) forming embryonic bodies from human pluripotent stem cells; b) attaching the embryonic bodies to a culture dish to induce natural differentiation of the embryonic bodies into mesenchymal stem cells; and c) performing continuous proliferative culturing of the mesenchymal stem cells while still maintaining the identity of the mesenchymal stem cells. Also, provided is a standardized method for inducing differentiation of mesenchymal stem cells, which can be broadly applied to all human pluripotent stem cells regardless of a difference in the genetic background thereof. Ultimately, the present invention can continuously mass-produces the mesenchymal stem cells necessary for regenerative medicine and cell therapy by using human pluripotent stem cells, thereby realizing practical uses of cell therapy products, and further the present invention is expected to highly contribute to treatments of incurable diseases, such as cardiovascular diseases and neurological disorders.

The object of the present invention is to stabilize bioactivation of iron salt. Said object is attained by adding a magnesium salt to said iron salt. Said iron salt stabilized by said magnesium salt is useful as medicine to treat incurable diseases such as diabetes and growth promoting agent of animals and plants.

Copper (I) chloride complex of pyrazinic acid is prepared, characterized by elemental analysis, IR, UV-visible spectra and its crystal structure determined by single crystal diffraction methods. This compound is found to exhibit a very positive influence as a drug, in a pharmaceutical acceptable composition for different incurable diseases, e.g. myopathy or weakness of muscles in general, infertility, and certain genetically causes disorders in mammals. These products were found to improve symptoms of myopathy, male infertility, fatigue and weakness of muscles for different reasons, and certain genetically causes disorders in mammals. It also enhanced regeneration of tissue affected by skin burns, scars, improved alopecia, decreased blood lipids and helped in loss of weight in obese patients. The observed wide scope of activities probably due to stem cell stimulation, enhancement the immune system and role of copper dependent enzyme activity.

The present invention relates to multipotent adult stem cells derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart, and a method for preparing the same as well as a cellular therapeutic agent containing the same, more specifically, to a multipotent adult stem cell isolated by culturing an eukaryotic cell derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart in a FBS-containing medium and a method for preparing the same. Adult stem cells according to the present invention are derived from canine umbilical cord blood, placental blood and blood sample from canine fetal heart. The adult stem cells have characteristics highly similar to human mesenchymal stem cells as well as remarkable cell growth at the initial step compared to human UCB-derived mesenchymal stem cells so that the cells are useful to treat canine incurable diseases and difficult-to-cure diseases. Furthermore, multipotent adult stem cells are effective to treat musculoskeletal diseases and neural diseases due to the ability to differentiate into osteogenic cells and neural cells.

The invention discloses a formula for treating multiple incurable diseases. The formula comprises the following components by weight: folium artemisiae argyi, sulphur, frankincense, musk, fructus gleditsiae abnormalis, fructus aurantii, rhizoma chuanxiong, cassia twig, cortex eucommiae, scorpion, radix angelicae dahurioae, herba asari, rosin, realgar, radix angelicae pubescentis, squama manitis, clove, safflower, herba taraxaci, herba hedyotidis diffusae, herba scutellariae barbatae, flos rosae rugosae, herba lobeliae chinensis, red paeony root, caulis bambusae in taeniam, radix clematidis, folium perillae, radix bupleuri and rhizoma corydalis. The formula is simple in proportion and convenient to use; the red paeony root is slightly cold in property and bitter in taste, belongs to the liver meridian and the stomach meridian, and has the effects of clearing heat and removing toxicity as well as cooling blood and relieving sore-throat; a medicine prepared according to the formula is high in permeability, material-saving and high in medicinal value, can directly arrive at the focus, and can be used for treating the multiple diseases such as arthralgia, impotence, epilepsy, asthma and tumors.

A method of reversing a clinical episode of a disease which is generally considered incurable in a subject. The method includes providing an immune-globulin preparation containing a detectable titer of antibodies to the disease that is generally considered incurable and administering die immune-globulin preparation to the subject. Preferably, the immune globulin preparation is a pool of immune globulin fractions gathered from blood of donors living in an area where the disease is endemic.