The invention discloses a
drug-
disease association prediction method,
system, device and medium, and relates to the technical field of
drug relocalization, and the method comprises the steps: constructing a
drug similarity network and a
disease similarity network; obtaining a binary
adjacency matrix through k-neighbor graphs of different nodes in the two similarity networks, carrying out weighted fusion on the binary
adjacency matrix through an attention coefficient to obtain a soft
adjacency matrix, and carrying out fine-grained graph
convolution updating to obtain drug features and
disease features; extracting heterogeneous node representations of drugs and diseases in the biochemical
heterogeneous network, and carrying out dynamic
weight distribution on different representations to obtain final embedding of drug nodes and disease nodes; and splicing the final embedding of the drug nodes and the final embedding of the disease nodes, and performing prediction according to the spliced features to obtain the drug-
disease association probability. According to the method, the potential complementary relationship between the two is fully mined, and the heterogeneous
feature fusion effect is improved, so that the performance and robustness of drug-
disease association prediction are integrally enhanced.