Degradable gasket with anti-bacterial anti-adhesion performance

An anti-adhesion and spacer technology, which is applied in medical science, surgery, coating, etc., can solve the problems of high irritation of surrounding tissues, reduced anti-adhesion effect, and insufficient suture strength, so as to reduce the risk of postoperative infection and improve biological Compatibility, the effect of promoting wound healing

Inactive Publication Date: 2015-05-13
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chitosan film has poor adhesion to the body, it is difficult to wrap and fix during surgery, the suture strength is obviously insufficient, and the degradation rate is not easy to control
Hyaluronic acid film has excellent biocompatibility and good biodegradability, high viscoelasticity, non-toxic, non-antigenic, but the retention time of sodium hyaluronate in the body is short, and it often disappears before the tissue is completely repaired. Degradation, leading to adhesions and poor hemostatic effect
Poly-DL-lactic acid absorbable anti-adhesion film can degrade lactic acid in the body, and then decompose it into carbon dioxide and water through the tricarboxylic acid cycle, which can be absorbed by the body and excreted from the bo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The degradable gasket with antibacterial and anti-adhesion functions provided in this embodiment is woven from pure magnesium wires, and the diameter of the pure magnesium wires is 1 mm.

[0025] biosecurity

[0026] Biological evaluation was carried out according to the experimental method described in GB / T16886. Experimental results show that the degradable spacer provided in this example has no obvious cytotoxicity and coagulation on 3T3 cells, and has no obvious sensitization, irritation and genotoxicity.

[0027] antibacterial properties

[0028] Experimental strains were used: Staphylococcus epidermidis strain (S. epidermidis), methicillin-resistant Staphylococcus epidermidis strain (MRSE) and Staphylococcus epidermidis strain (ATCC35984) purchased from the American Standard Bacteria Bank. The antibacterial test is in accordance with the standards of "JISZ2801-2000 "antibacterial processed products-antibacterial performance test method and antibacterial effect",...

Embodiment 2

[0038]The degradable gasket with antibacterial and anti-adhesion functions provided in this embodiment is braided from Mg-Zn wires (with a magnesium content of 97 wt%), and the diameter of the Mg-Zn wires is 0.8 mm.

[0039] biosecurity

[0040] Biological evaluation was carried out according to the experimental method described in GB / T16886. Experimental results show that the degradable spacer provided in this example has no obvious cytotoxicity and coagulation on 3T3 cells, and has no obvious sensitization, irritation and genotoxicity.

[0041] antibacterial properties

[0042] Experimental strains were used: Staphylococcus epidermidis strain (S. epidermidis), methicillin-resistant Staphylococcus epidermidis strain (MRSE) and Staphylococcus epidermidis strain (ATCC35984) purchased from the American Standard Bacteria Bank. The antibacterial test is in accordance with the standards of "JISZ2801-2000 "antibacterial processed products-antibacterial performance test method and ...

Embodiment 3

[0052] The degradable gasket with antibacterial and anti-adhesion functions provided in this embodiment is woven from Mg-Zn-Sr wires (with a magnesium content of 96 wt%), and the diameter of the Mg-Zn-Sr wires is 0.7 mm.

[0053] biosecurity

[0054] Biological evaluation was carried out according to the experimental method described in GB / T16886. Experimental results show that the degradable spacer provided in this example has no obvious cytotoxicity and coagulation on 3T3 cells, and has no obvious sensitization, irritation and genotoxicity.

[0055] antibacterial properties

[0056] Experimental strains were used: Staphylococcus epidermidis strain (S. epidermidis), methicillin-resistant Staphylococcus epidermidis strain (MRSE) and Staphylococcus epidermidis strain (ATCC35984) purchased from the American Standard Bacteria Bank. The antibacterial test is in accordance with the standards of "JISZ2801-2000 "antibacterial processed products-antibacterial performance test method...

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Abstract

The invention provides a degradable gasket with anti-bacterial anti-adhesion performance. The degradable gasket is prepared via weaving or knitting of a plurality of bundles of magnesium-based metal wire, or via punching of magnesium-based metal sheets. The magnesium-based metal wire can be made of pure magnesium or a magnesium-based alloy of different elements based on disease characteristics and treatment requirements. The degradable gasket possesses excellent biocompatibility; in vivo degradation and absorption can be realized; degradation speed can be controlled; the degradable gasket is capable of preventing postoperative adhesion and infection, and promoting wound healing, can be used for preventing epidural adhesion after orthopedic surgery laminectomy, adhesion after tendon rupture repairing operation, adhesion after knee surgery, dura adhesion after transcranial surgery, eye socket soft tissue adhesion, intestinal adhesion after abdominal surgery, and intrauterine adhesion, is capable of reducing infection risk of the above surgeries, and possesses significant clinical application value.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a degradable gasket with antibacterial and anti-adhesion functions. Background technique [0002] Preventing postoperative tissue adhesion in surgical operations is a common problem in various fields of surgery. Severe tissue adhesion will cause corresponding clinical complications. Joint stiffness affects the recovery of postoperative motor function. Tendon injury such as Achilles tendon rupture and tendon adhesion after repair is also a common clinical problem. Posterior lumbar discectomy often requires removal of part or all of the lamina, but fibrous fibers are prone to appear after surgery. Scar hyperplasia, adhesion to dura mater and nerve root causes compression on both, which can cause neurological symptoms and affect the surgical effect; brain tissue adhesion in craniotomy can cause traumatic epilepsy; orbital space is small but prone to postoperative soft tissue Adh...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/14A61L31/10A61L31/08
Inventor 曲新华戴尅戎
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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