Topical arginine-silicate-inositol for wound healing

a technology of arginine-silicate inositol and wound healing, which is applied in the field oftopical or transdermal delivery, can solve the problems of limited success of wound closure methods, inability to resist and more dangerous infections, and inability to cure infections, etc., and achieves the effects of promoting hair growth, hair growth, and hair growth

Inactive Publication Date: 2017-05-18
NUTRITION 21 INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0022]In some embodiments, the composition is applied to non-wounded tissue. In some embodiments, the composition is applied to the scalp. In some embodiments, the composition promotes hair growth. In some embodiments, hair growth is promoted at a shaved area. In some embodiments, hair growth is promoted after treatment with chemotherapy. In some embodiments, hair growth in promoted in balding areas. In some embodiments, the composition increases the rate of hair growth. In some embodiments, the composition increases hair thickness. Use for facilitating or promoting hair growth may be done in conjunction with wound healing or independent of wound healing, and may be applied to broken or unbroken skin to facilitate hair growth.
[0023]The compositions disclosed herein may be used for decreasing wound healing time, decreasing wound scarring, promoting hair growth, and / or reducing inflammation. In some aspects, a method for decreasing wound healing time includes applying a topical composition comprising an effective amount of ASI to a wound, wherein the amount decreases wound healing time in comparison to not applying the composition. In some aspects, a method for decreasing wound scarring includes applying a topical composition comprising an effective amount of ASI to a wound, wherein the amount decreases scarring from the wound in comparison to not applying the composition. In some aspects, a method for promoting hair growth includes applying a topical composition comprising an effective amount of ASI to a treatment area on a mammalian subject, wherein the amount promotes hair growth in the treatment area in comparison to non-treatment areas. In some aspects, a method for reducing inflammation includes applying a topical composition comprising an effective amount of ASI to a treatment area on a mammalian subject, wherein amount reduces inflammation in the treatment area in comparison to non-treatment areas.

Problems solved by technology

When barriers are broken, infections occur.
Antimicrobial treatment of early infections may alter the course of the infection, resulting in more resistant and more dangerous infections.
Inadvertently, this important strategy can have negative outcomes on an individual patient, where targeted antibiotics result in the emergence of an aggressive, different microorganism (for example, Pseudomonas).
Current methods of wound closure, such as suturing and grafting have limited success; both methods leave the subject vulnerable to infection, and the subject will likely have significant scarring resulting from these procedures.

Method used

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  • Topical arginine-silicate-inositol for wound healing
  • Topical arginine-silicate-inositol for wound healing
  • Topical arginine-silicate-inositol for wound healing

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0077]Animals: In this study, 42 male, 4 months old, Wistar albino rats weighing between 250 and 300 g were used. Animals were housed at 21° C. with a day / night cycle of 12 h. During the study these animals were fed ad libitum standard rodent feed. Guidelines for the care and use of animals approved by the relevant institution were followed and the local ethics committee approved this study.

[0078]Anesthesia: The rats were anaesthetized with single intramuscular injection of 6 mg / kg xylazine hydrochloride (Rompun, Bayer, 23.32 mg / ml) and 85 mg / kg ketamine hydrochlorure (Ketalar, Parke-Davis, 50 mg / ml).

[0079]Test drugs: 4% and 10% arginine-silicate inositol (ASI)(w / w) ointment, and cold cream (Botafarma, 12.5% spermaceti+12% white wax+56% liquid paraffin+0.5% borate of soda+19% distilled water) were used in this study.

[0080]Wound model: The dorsal surfaces of the rats were shaved and prepared with 10% antiseptic povidone-iodine solution (Kim-Pa, Poviiodeks, % 10 povidone-iodine). Then...

example 2

[0107]Wound model: The dorsal surfaces of the rats will be shaved and prepared with 10% antiseptic povidone-iodine solution (Kim-Pa, Poviiodeks, % 10 povidone-iodine). Then a surgical cautery will be used to create a full-thickness burn wound.

[0108]Measurements: On every bandage change, the wound boundaries will be traced on a transparent sheet with a fine-tipped permanent marker. These transparent sheets will be scanned and the areas of wound sites and epithelization fronts will be measured with the help of the paint-brush (PB) computer program. The data obtained will be calculated with the following formula: Area (cm2)=P / K.M, where P is the value of a particular wound site obtained on the PB, K is a rate constant for expressing the values of the PB as cm2, and M is the magnitude of tracings after scanning. During the qualitative examination, the expansion rate, the day wound contraction started, the fraction of the wound healed with contraction, the rate of wound contraction, the ...

example 3

[0109]Wound model: The dorsal surfaces of the rats will be shaved and prepared with 10% antiseptic povidone-iodine solution (Kim-Pa, Poviiodeks, % 10 povidone-iodine). Then the rats will be given a 5 cm by 5 cm abrasion wound.

[0110]Measurements: On every bandage change, the wound boundaries will be traced on a transparent sheet with a fine-tipped permanent marker. These transparent sheets will be scanned and the areas of wound sites and epithelization fronts will be measured with the help of the paint-brush (PB) computer program. The data obtained will be calculated with the following formula: Area (cm2)=P / K.M, where P is the value of a particular wound site obtained on the PB, K is a rate constant for expressing the values of the PB as cm2, and M is the magnitude of tracings after scanning. During the qualitative examination, the expansion rate, the day wound contraction started, the fraction of the wound healed with contraction, the rate of wound contraction, the day epithelizatio...

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Abstract

The present invention generally relates to compositions and methods for topical or transdermal delivery, for promoting wound healing, reducing scarring, and/or promoting hair growth. Specifically, the present disclosure is directed to a topical arginine silicate formulation that demonstrates surprising improvement in wound healing time leading to more advantageous recovery and reducing hospital costs. Such formulations may also lessen scarring. The formulations may, for example, be applied to skin or to mucous membranes to facilitate wound healing.

Description

BACKGROUND[0001]Field[0002]The present invention generally relates to compositions and methods for topical or transdermal delivery, for promoting wound healing, reducing scarring, and / or promoting hair growth.[0003]Description of the Related Art[0004]When barriers are broken, infections occur. Surgery, trauma (for example, scrapes, lacerations, punctures, abrasions, and burns), medical instrumentation (for example, catheterization, ventilation), chronic wounds (for example, diabetic foot ulcers) and a variety of diseases disrupt our natural barriers of defense. Wounds may become contaminated with microbes and may provide an excellent environment for microbial growth. Bleeding and leakage may provide fluids and nutrients that ultimately support microbial growth. Bacterial or fungal colonization, and / or overt infection may occur. Various surgical, trauma and medical settings all involve disruption of our natural barriers of defense and deserve special attention because the outcomes ca...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/155A61K33/00A61K31/7004
CPCA61K31/155A61K33/00A61K31/7004A61K31/198A61K2300/00
Inventor KOMOROWSKI, JAMES R.
Owner NUTRITION 21 INC
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