44results about How to "Promotes hair growth" patented technology

This invention relates to compositions and processes for stimulating the growth of mammalian hair comprising the topical application of compositions comprising a hair growth stimulating and / or hair loss prevention agent, and a hair and / or skin lightening and / or neutralization agent, in association with a topical pharmaceutical carrier. Unlike other products, the composition of the invention can be used with dyed / treated hair so as to not affect the color of the hair.

The present invention relates to methods of modulating epithelial stem cell lineage by regulating the expression of Lef1 or a BMP inhibitor and / or the stability of β-catenin or the expression of a Wnt; regulating the expression or activity of GATA-3; or regulating BMPR1A activity either at the level of receptor expression or at the level of pathway activation. Methods of regulating E-cadherin, GATA-3, BMPR1A and HK1-hair keratin and methods of identifying agents which modulate the epithelial stem cell lineage are further provided. Such agents are useful for inhibiting or stimulating inner root sheath development or hair follicle formation.

This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.

A method of enhancing scalp hair growth utilizes insulin and / or IGF-1 alone or in combination with other known hair growth promoting therapeutic, pharmaceutical and biological agents to increase the therapeutic effects of hair regrowth strategies to enhance hair growth on the scalp and as method of treatment for balding.

A method for utilizing an individual's undifferentiated papilla and / or bulge area stem cells to stimulate hair growth. The inventor has discovered that bulge area stem cells can be harvested, isolated, cloned, and successfully transplanted into an area of the donor's skin where increased growth of hair is desired to increase hair growth therein. In the first step of the method, a donor section of skin is identified having growth of the type of hair for which increased growth at the recipient site is sought. Since hair types differ according to their anatomical site, it is generally desirable to match the hair produced by the donor stem cells to the type of hair that is desired at the recipient site. For example, in treatment of male pattern baldness, tissue samples are harvested from an area of the scalp that still exhibits vigorous growth. Once the donor site is identified, it is anesthetized locally using any convenient means and a plurality of tissue samples are obtained from the donor site. The tissue samples preferably contain hair follicles with intact undifferentiated papilla and / or dermal stem cells, as well as immediately surrounding tissues. Any method of tissue sampling can be employed, for example, punch biopsy, so long as viable stem cells can be obtained. The stem cells are cloned to multiply the number of cells preferably by about 10 to 1,000 times or more. Some of the stem cells can be frozen for later use. Some of the stem cells are inserted into skin regions where hair restoration is desired. Various techniques are disclosed for inserting the stem cells into the skin.

PCT No. PCT / GB95 / 02166 Sec. 371 Date Mar. 14, 1997 Sec. 102(e) Date Mar. 14, 1997 PCT Filed Sep. 13, 1995 PCT Pub. No. WO96 / 08231 PCT Pub. Date Mar. 21, 1998A method for treating hair loss is disclosed by topically adminstering an aromatase inhibitor to a mammal, including humans, on the area to be treated.

This invention relates to a method for achieving a novel solution comprising a high percentage of a piperidinopyrimidine derivative, more particularly minoxidil. The method of the current invention results in a highly effective solution for facilitating hair growth comprising a high concentration of Minoxidil, that is not cosmetically unattractive when applied to a treatment area and that does not cause skin irritation in the treatment area. In another aspect of the invention, said solution comprising high percentage Minoxidil may further comprise co-active ingredients, such as azelaic acid. The present invention also provides a method for stimulating the growth of hair or for preventing hair loss in humans and lower animals.

This invention relates to a composition of matter for producing hair growth and preventing hair loss in humans and the method for using said composition. The composition comprises four complexes and a carrier liquid, mixed together and added to any topical treatment or produced as an ingestible dietary supplement. Complexes 1, 2, and 3 are comprised of substances that prevent hair loss while Complex 4 promotes hair growth. Complex 1 is comprised of octyl butyrate and glutaminpeptides. Complex 2 comprises a mixture of minerals, plant extracts, vitamin B6, and linolenic acid. Complex 3 comprises a mixture of Ginkgo biloba extract, emu oil, a source of silicon, and a blend of amino acids. Complex 4 comprises a mixture of several plant extracts. The product should be used by the consumer at regular intervals, preferably 5 to 7 times per week in the form of a serum.

A handled laser treatment device provides a plurality of branched light pipes or light distribution tips distributed so as to evenly deliver laser radiation to the surface of the scalp. To make efficient use of each laser diode, each laser can coupled to a branched light pipe with the branches arranged to distribute light directly to the surface of the scalp. Each laser source is connected to a three branch light pipe. Alternatively, each laser diode can be directly coupled to a light distribution tip arranged in a triad. Each light pipe or light distribution tip acts as a tine or tooth in a comb to bring laser radiation to the scalp free of obstruction by hair, etc., with a tripod configuration that allows each light pipe assembly to evenly contact the rounded surface of the scalp. The branched light pipes or the light distribution tips are preferentially coupled to a flexible membrane so as to be capable of independent orientation allowing improved contact of the distal ends of the tripods or triads to the scalp.

Novel compositions for hair loss prevention and / or hair growth promotion comprising at least active agent preferably derived from natural source such as from the plant Vernonia sp., either alone or in combination with other active agent(s) and optionally one or more excipient(s) are provided. The process for the extraction of hair growth promoting agent and preparation of compositions comprising such active agent are also described. The novel composition is preferably in the form of an oral or topical preparation such as tablet, capsule, liquid solution or suspension, cream, gel, lotion or spray and is useful against hair disease(s) / disorder(s) and / or other associated disorders particularly in the management of testosterone induced androgenic alopecia.

The present invention teaches all-natural formulations comprising amino acids for hair application. These formulations can be used for a wide range of hair treatments including hair detangling, hair curl loosening, hair straightening, for preventing hair breakage and stimulating hair growth. The methods used to generate the formulations are disclosed, along with the methods for treating hair with the formulations to attain one or more desired benefits.

A topical composition or a personal beauty care product (e.g., soap, shampoo, rinse, hair conditioner, and the like) comprises chemical or biological substances or plant extracts obtained from certain plants, in particular, plant species of the family Liliaceae or Amaryllidaceae, preferably selected from the following Allium species such as Allium fistulosum, Allium ampeloprasum or Allium porrum, or other Allium species or their relative species having ingredients which can stimulate hair growth and / or reduce hair loss. The plant species can preferably be selected from bunching onion, scallion, Welsh onion, green onion, great green onion, spring onion, leek, wild leek, Egyptian leek, shallot, and Korean or Asian great green onion, or the like.

The present invention relates to a hair growth caring apparatus that includes a head housing, a head pin protruded from a lower side of the head housing, a power generation device fixed to a lower side of the head pin for thereby generating power, a light generation device for generating light, and a heat generation device capable of generating heat, thus preventing the side effects of an artificial depilation agent or transplantation of hair in such a manner that electric energy and light energy are supplied to hair fallen portions, so that it is possible to achieve a natural hair growth for depilation patient.

Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent / reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.

Disclosed herein are topical compositions of 5-α reductase inhibitors, such as dutasteride or finasteride, or a pharmaceutically acceptable salt, ester, or derivative thereof and the use of the compositions for the treatment of hair loss secondary to endocrine therapy in patients with breast cancer (Endocrine Therapy-Induced Alopecia or ETIA), androgenetic alopecia (AGA), alopecia areata, and hirsutism. The topical composition is advantageous over the existing oral compositions of 5-α reductase inhibitors because the topical composition is safer and more effective. The topical formulation may allow for a slow release of the active ingredient dutasteride, better penetration at the therapeutically effective amount of dutasteride with an improved safety profile because it does not need to travel through the bloodstream to be efficacious, thereby minimizing the risk of systemic side effects.

This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and / or improving vision, and for treating memory impairment and / or enhancing memory performance by administering such compounds.

The present invention relates to a method of promoting hair growth comprising administering a fibroblast growth factor receptor 3 (FGFR3) extracellular domain (ECD), including native FGFR3 ECDs, variants, fragments, and fusion molecules, to a subject in an amount sufficient to promote hair growth.

The present invention generally relates to compositions and methods for topical or transdermal delivery, for promoting wound healing, reducing scarring, and / or promoting hair growth. Specifically, the present disclosure is directed to a topical arginine silicate formulation that demonstrates surprising improvement in wound healing time leading to more advantageous recovery and reducing hospital costs. Such formulations may also lessen scarring. The formulations may, for example, be applied to skin or to mucous membranes to facilitate wound healing.

The present invention relates to a use of a crude extract, non-polar solvent soluble extract or purified extract of the hardy kiwifruit for the preparation of therapeutic agent for treating and preventing baldness disorder and seborrheic skin disease in human and mammal, and health care food, food additives, feed additives, cosmetic composition comprising the same. The hardy kiwifruit reduced blood DHT level, promoted the formation of hair root in mouse model experiment, and inhibited the falling out of hair and improved seborrheic skin disease of volunteers such as keratigenous skin, seborrhea etc.

The present invention relates to an extract or fraction of Cinnamomum aromaticum, Arctium lappa, Viticis fructus, Lonicera japonica, Acanthopanax gracilistylis, Raphanus sativus, Astragalus membranaceus and Hordeum vulgare, and a composition comprising said extract or fraction. The invention also relates to the use of said composition for treating or preventing cancers, preventing loss of hair, and stimulating hair growth. The invention also relates to a process for preparing said composition.

Disclosed herein is an intradermal pharmaceutical composition for application to the scalp of a person for improving the bodily appearance comprising plurality of growth factors, peptides and nourishing complex in an amount effective to treat or to prevent hair loss by stimulating hair follicles and promoting hair growth, where such hair growth improves the bodily appearance of the said person.

The invention mainly relates to a purely natural plant combined food, in particular to blood enriching and anti-aging food combination which is characterized in that the invention is made of the raw materials with the following weight percent: 20 to 50 percent of angelica, 5 to 30 percent of milkvetch root, 5 to 30 percent of Chinese wolfberry fruit, 5 to 25 percent of longan, 1 to 10 percent of walnut and 1 to 10 percent of black sesame. The invention adopts the preparation method that medicinal herbs of 1 to 70 percent of the angelica, 1 to 70 percent of the milkvetch root, and 1 to 70 percent of the Chinese wolfberry fruit, etc. are crumbled into 40-screen powder, water with the amount being four times of the powder is added, put in constant temperature water with 75 DEG C, and then heated for extraction for 2 hours and cooled, the mixture is filtered by a gauze to remove the impurities, and is put in a refrigerator 4 DEG C for more than 24 hours, in order to remove settled supernatant and be concentrated to 1 to 1.2 for standby usage; the longan and the walnut are chopped into 1 to 5 mm for standby usage; the flour is steamed, cooled and rolled, and the walnut, the black sesame and sugar, etc. are added in sequence and then stirred, and then the extract of refined oil, the milkvetch root and the Chinese wolfberry fruit, etc., are added and mixed uniformly for standby usage. The invention has the advantages that the plant combination has mutually synergistic action, and the invention has good functions of blood as well as Qi enrichment, anti aging, skin caring and essence and blood relieving.

Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. A peptide formed from the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, according to the present invention, consequently shows an anti-inflammatory activity by inhibiting an inflammatory cytokine expression and proliferation of inflammatory cells, and consequently promotes osteogenic differentiation by increasing phosphorylation of PI3K, Smad1, Smad5 and Smad8, which contribute to osteogenesis, and by increasing ALP, OPG and BSP expressions. And a peptide formed from the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, consequently shows efficacy for preventing hair loss and promoting hair growth by promoting proliferation of hair follicle cells and human umbilical vein endothelial cells, increasing phosphorylation of EPK, increasing expressions of PI3K, β-catenin, IGF-1, KGF and Wnt3a which are proteins that contribute to hair growth, and reducing an expression of DKK-1 which is a hairless gene.

An antimicrobial film formulation is prepared by extracting Portulaca oleracea using chloroform, petroleum ether or hot water, filtering and concentrating the extract, processing the concentrated extract into a liquid or powder state, and completely dissolving 0.25-0.5% (w / v) of the Portulaca oleracea extract, 1.5-2% (w / v) of chitosan and 0.5-2% (w / v) of glycerol in 100% (v / v) of vinegar (containing about 3-5% acetic acid).

Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3 -L finds use in treating patients with anemia, AIDS and various cancers.

The present invention relates to a formulation for promoting hair growth and preventing hair loss. Supplementation with the formulation promotes hair growth and increases the number of hairs in mammals. In one embodiment, a composition for promoting hair growth and reducing hair loss according to the present invention comprises mixed tocotrienols and a pharmaceutically acceptable excipient.

The present invention relates to a composition comprising centipede grass extract as an active ingredient for the prevention or treatment of alopecia. Particularly, the centipede grass extract of the present invention increases the expression of hair growth related factors and accelerates hair growth, so that it can be effectively used for the prevention or treatment of alopecia.

Disclosed is a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. Also disclosed is a method for preparing a novel adamantine derivative compound, an isomer thereof, pharmaceutically acceptable salt thereof, prodrug thereof, hydrate thereof or a solvate thereof. The novel adamantane derivative compound or the like has an excellent anti-androgenic effect.

An agent for promoting hair growth and a preparation method for the same are provided. The method for preparing an agent for promoting hair growth that includes: (1) preparing an extract from eight medicinal herbs combined together at an optimal combination ratio to contain 50 to 70 wt. % of Rumex japonicas HOUTT, 3 to 6 wt. % of Pleuropterus multiflorus, 1 to 2 wt. % of Radix Notoginseng, 1 to 2 wt. % of safflower (Carthamus tinctorius L.), 1 to 2 wt. % of Cnidium officinale, 0.5 to 1 wt. % of Mentha Arvensis var. Piperascens, 0.5 to 1 wt. % of Asarum sieboldii, and 0.5 to 1 wt. % of Glycyrrhiza uralensis Fischer; and (2) adding 10 to 15 wt. % of a purified horse fat to the extract. The present invention exhibits the remarkable effects of promoting hair growth, preventing hair loss, and providing skin care functions through the treatment of the underlying diseases, such as kidney infection, heart problems and liver disorders, that are in direct and close relation to hair loss, and by promoting blood circulation and metabolic activity.