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Collagen gel and preparation method thereof

A collagen and gel technology, applied in the field of collagen gel and its preparation, can solve the problems of complex production process of in vitro growth factors, high cost of cell growth factors, and high treatment costs for patients, so as to facilitate wound healing and improve operation efficiency. effect, the effect of reducing pigmentation

Active Publication Date: 2010-09-15
GUANGZHOU TRAUER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Adding growth factors can also promote wound repair, but the production process of in vitro growth factors is relatively complicated, and generally requires recombinant fermentation methods for extraction and purification
This process is easy to introduce exogenous substances, and the biological safety needs to be further evaluated. In addition, due to the complicated process, the cost of producing cell growth factors is relatively high. For example, it is difficult to carry out large-scale industrial production, and patients often have to bear the burden. high cost of treatment

Method used

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  • Collagen gel and preparation method thereof
  • Collagen gel and preparation method thereof
  • Collagen gel and preparation method thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0030] The collagen gel of this embodiment is prepared from the following components according to the following method: after dispersing and dissolving the matrix with a dispersant in a clean environment of grade 10,000 or above, adding the dispersant, matrix, The mixture of preservatives, antibacterial agents, collagen liquid and film-forming agent and distilled water; fully mixed under the condition of rotating speed 50-200 r / min, left to stand for defoaming and then filled into sterilized medicinal packaging materials, That is, collagen gel is obtained. Above-mentioned each component and its weight number are: dispersant is propylene glycol, matrix is ​​hydroxypropyl methylcellulose (HPMC, its intrinsic viscosity is 4000mPa s), and preservatives are medical methylparaben and propylparaben The ester and antibacterial agent are nano silver, and the film-forming agent is polyvinyl alcohol 124 (PVA124). 1g gel contains 2.7mg collagen, 0.05mg nano silver (concentration 50ppm, p...

Embodiment 2

[0038] The collagen gel in this example is composed of the following components, and the components and weight percentages are: 1 g of gel contains 0.5 mg of collagen, 15 mg of chitosan, 30 mg of medical grade ethylparaben, 10 mg of HPMC, PVP- VA-645mg, butanediol 50mg, others are supplemented with distilled water. The above collagen gel was subjected to bacteriostatic test, and the results were shown in Table 2 below.

[0039] Table 2

[0040]

[0041]

[0042] The collagen gel in this embodiment can be used for the care and repair of skin tissue after superficial second-degree burns and scalds, and to lighten or lighten the scar. It has good bacteriostatic effect on various bacteria, molds and fungi. image 3 is the SDS-PAGE chart of collagen gel in this example, wherein 1 is the sigma type I collagen standard, and 2-6 are all collagen gel samples. The results of electrophoresis showed that there were still collagen bands in the gel. Figure 4 It is a scanning elec...

Embodiment 3

[0044] The collagen gel of the present invention is composed of the following components, and the components and weight percentages are: 1 g of the gel contains 4 mg of collagen, 2.8 mg of medical grade methylparaben, 0.2 mg of propylparaben, and 47 mg of EuxylPE9010. , HPMC 10mg, butanediol 10mg, propylene glycol 50mg, PVA124 1mg, others are supplemented with distilled water. In this embodiment, the HPMC is replaced with guar gum, which becomes another embodiment.

[0045] The collagen gel in this embodiment can be used for the care and repair of sensitive skin tissue after plastic and cosmetic surgery, and to lighten and lighten scars and pigmentation. It has good bacteriostatic effect on various bacteria, molds and fungi. Table 3 shows the results of the antibacterial test of this batch of collagen gels, which shows that it has a good antibacterial effect. Figure 5 is the SDS-PAGE chart of the collagen gel in this example, wherein 1 is the sigma type I collagen standard,...

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Abstract

The invention provides a collagen gel and a preparation method thereof. The collagen gel comprises collagen and an antibacterial agent, wherein the antibacterial agent is at least one of chitosan and nano silver. The collagen gel also comprises a preservative, a substrate, a dispersing agent, a film-forming agent and water; and 1g of gel comprises 0.5 to 8.0mg of collagen, 0.001 to 15mg of antibacterial agent, 1 to 50mg of preservative, 10 to 50mg of matrix, 50 to 100mg of dispersing agent, 1 to 10mg of film-forming agent, and the balance of water. The method for preparing the collagen gel comprises the following steps of: performing dispersion and dissolution on the substrate by adopting the dispersing agent under ten-thousand grade clean environment; adding the dispersing agent, the substrate, the preservative, the antibacterial agent, and collagen solution into a vacuum emulsified homogenizer one by one; after fully mixing, standing and defoaming, filling the product. The collagen gel is applied to various open wounds and infected wounds, lightens hyperpigmentation, has good effect of accelerating wound healing, and can maintain long-term anti-bacteria function.

Description

technical field [0001] The invention relates to the field of medical supplies, in particular to a collagen gel and a preparation method thereof. Background technique [0002] Clinically, there are more and more trauma patients caused by various external factors and various acute and chronic diseases, especially ulcers caused by various chronic diseases. In clinical treatment of such wounds, disinfection is generally performed first, and then various therapeutic drugs are applied. This type of treatment has certain limitations in wound treatment. For example, wound treatment mainly focuses on reducing or avoiding infection, and providing a clean environment for the wound to allow the wound to repair itself; however, this treatment method has frequent dressing changes. , slow wound healing and other shortcomings. In addition, for example, after laser and photon therapy, scarring and hyperpigmentation may occur. Moreover, most of the antibacterial dressings on the market are...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K9/00A61K8/73A61K8/65A61K8/19A61K8/02A61P17/02A61P31/00A61Q19/00A61K31/722A61K33/38
Inventor 佟刚雷静陈淡嫦黄冬晶王民菲
Owner GUANGZHOU TRAUER BIOTECH
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