Wound-protection liquid, and its preparing method

A liquid agent and pure water technology, applied in the field of wound care solution, can solve the problems of harsh processing conditions, irritating smell, and lack of permeability, etc., and achieve the effects of shortening the healing time, no side effects, no peculiar smell, and shortening the treatment cycle

Active Publication Date: 2009-11-18
苏州汇涵医用科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above four patented technical solutions, the first three belong to the category of non-medical clinical disinfectant solution, which is used for disinfection and sterilization of utensils such as tableware and bathware in people's daily life, as well as cleaning and sterilization of skin (CN1262101A) , not suitable for infection control such as burns, scalds, open wounds and wounds on the human body surface
And the fourth document (CN1110557A) belongs to traumatic treatment medicine, in this document, also pointed out the advantage and disadvantage of silver sulfadiazine ointment, excellent namely its curative effect in burn surgical medication and occupies the pivotal position always The disadvantages are frequent local or systemic allergic reactions, increasing drug-resistant strains, irritating smell, inhibition of human epidermal cell growth, and adverse effects on kidney function.
However, this patented technical solution also has deficiencies. First, the treatment effect on the deep part of the wound is not ideal, because it is as impermeable as sulfadiazine silver cream; secondly, the formula has many raw materials; the processing conditions introduced are harsh

Method used

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  • Wound-protection liquid, and its preparing method
  • Wound-protection liquid, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A) Add 0.18g of superfine silver ion powder produced and sold by commercially available, such as Shenzhen Zhiyuan Kejia Technology Co., Ltd., Guangdong Province, China, to 10g of silver ion powder, and the purity measured by the conductivity meter is 0.1- Stir evenly in 0.16μs / cm deionized water, and the container used can be either a polyethylene plastic container or a stainless steel container, until the silver ion powder is fully dissolved, thereby obtaining the silver ion powder liquid;

[0026] B) 0.52g of reagent-grade phosphoric acid is added to the silver ion powder liquid obtained in step A) to carry out acidification treatment, the time of acidification treatment is 30min, and the pH is adjusted to obtain the silver ion powder mixed solution after acidification treatment;

[0027] C) adding 0.42 g of reagent-grade tartaric acid obtained commercially, such as produced and sold by China Shanghai Reagent No. 1 Factory, into 10 g of deionized water with the same pu...

Embodiment 2

[0033] A) Add 0.22 g of superfine silver ion powder produced and sold by commercially available, such as Shenzhen Zhiyuan Kejia Technology Co., Ltd., Guangdong Province, China, to 10 g of silver ion powder, and the purity measured by the conductivity meter is 0.1- Stir evenly in distilled water of 0.16μs / cm, the container used can be either a polyethylene plastic container or a stainless steel container, until the silver ion powder is fully dissolved, so as to obtain the silver ion powder body liquid;

[0034] B) 0.66g of reagent-grade phosphoric acid is added to the silver ion powder liquid obtained in step A) to carry out acidification treatment, the time of acidification treatment is 18min, and the pH is adjusted to 1.8 to obtain the silver ion powder mixed solution after acidification treatment ;

[0035] C) adding 0.50 g of reagent-grade tartaric acid obtained commercially, such as produced and sold by China Shanghai Reagent No. 1 Factory, into 10 g of distilled water wit...

Embodiment 3

[0040] A) Add 0.30 g of superfine silver ion powder, such as produced and sold by Shenzhen Zhiyuan Kejia Technology Co., Ltd., Shenzhen City, Guangdong Province, into 10 g of commercially available and the purity measured by the conductivity meter is 0.1- Stir evenly in 0.16μs / cm deionized water, and the container used can be either a polyethylene plastic container or a stainless steel container, until the silver ion powder is fully dissolved, thereby obtaining the silver ion powder liquid;

[0041] B) Add 0.74g of reagent-grade citric acid to the silver ion powder liquid obtained in step A) to carry out acidification treatment, the time of acidification treatment is 35min, adjust the pH to 1.5, and mix the silver ion powder after the acidification treatment liquid;

[0042] C) adding 0.66 g of reagent-grade tartaric acid obtained commercially, such as produced and sold by China Shanghai Reagent No. 1 Factory, into 10 g of deionized water with the same purity of 0.1-0.16 μs / cm a...

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PUM

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Abstract

The invention relates to a wound-protecting liquid, which is suitable for controlling the infection of wounds on the human body surface and promoting wound healing, and also relates to a preparation method of the wound-protecting liquid, which belongs to the technical field of medicine for medical surgery. Each 1000g weight of the finished solution formed by it contains: silver ion powder 0.16-0.36g, gelatin 0.10-0.40g, dibasic acid 0.50-1.00g, penetrant 12-14.3g, tartaric acid 0.40-0.80g, The rest is pure water. One of the advantages is that the stabilizer with penetration effect is used in the formula, which can penetrate into the deep tissue of the wound, kill the bacteria and endotoxin in the deep part, and loosen and dissolve the necrotic tissue, pus and blood clots out of the body, which helps It can shorten the wound healing time; second, it will not form obvious drug film and drug resistance after long-term use, and can effectively shorten the treatment cycle; third, it has no side effects on patients and the product has no peculiar smell and no allergies; fourth , the method has few process steps, and the conditions are not harsh, and can adapt to the requirements of mass production.

Description

technical field [0001] The invention relates to a wound-protecting liquid, which is suitable for controlling infection of human body surface wounds and promoting wound healing, and also relates to a preparation method of the wound-protecting liquid, which belongs to the technical field of medical and surgical medication. Background technique [0002] At present, the medicines for wound infection caused by burns, scalds, and open wounds are mainly sulfadiazine silver cream (also known as ointment) or suspension, and its active ingredients are mainly sulfadiazine except sulfadiazine. Is a silver ion, the drug is widely used clinically. However, the following deficiencies have been exposed in clinical application: First, because this drug is not permeable, it is difficult to effectively kill the bacteria in the deep part of the wound, and it is easy to form an obvious drug film on the surface, resulting in a longer wound healing time. The second is that the wound necrotic tiss...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K33/38A61P17/02
Inventor 孟孝平孟勇冯永良
Owner 苏州汇涵医用科技发展有限公司
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