6 results about "Periostin" patented technology

The present invention provides a biomarker for the detection of glioma microenvironment (TME), comprising a serum marker selected from any one or more of annexin A1 (ANXA1), annexin A2 (ANXA2), matrix metalloproteinase 14 (MMP14) and potential transforming growth factor beta binding protein 2 (LTBP2), and a pathological marker selected from any one or more of Annexin A1 (ANXA1), Annexin A2 (ANXA2), matrix metalloproteinase 14 (MMP14) and potential transforming growth factor beta binding protein 2 (LTBP2); the pathological marker is selected from one or more of periostin (POSTN), lactoferrin (LTF) and a phospholipase A2 group IIA (PLA2G2A), and the pathological marker is selected from one or more of periostin (POSTN), lactoferrin (LTF) and phospholipase A2 group IIA (PLA2G2A). The invention also provides an application of the biomarker in diagnosis of glioma. The invention provides an innovative idea and a biomarker for non-invasive diagnosis of glioma, and can be used for prognosis and malignant diagnosis of glioma.

A pharmaceutical composition containing a stem cell secretion, and a pharmaceutically acceptable excipient thereof. The protein in the stem cell secretion comprises one, two or three proteins selected from a group consisting of a pigment epithelium-derived factor (PEDF), a tissue inhibitor of metalloproteinase 1 (TIMP-1), a secreted protein acidic and rich in cysteine (SPARC), an α2-HS glycoprotein (AHSG), a periostin (POSTN), a decorin (DCN), the retinoic acid receptor responder 2 (RARRES2), the glia-derived nexin (GDN), the Sparc / osteonectin, cwcv and kazal like domains proteoglycan 1 (SPOCK1), and the follistatin-like 1 (FSTL1). The pharmaceutical composition is used for treating degenerative ocular diseases including retinal degeneration, retinitis pigmentosa, glaucoma, macular degeneration, etc.

The present application belongs to the field of biomedical and cosmetic technology, and particularly relates to the application of periostin in the preparation of preparations for promoting the activity of hair follicle cells or for preventing and treating alopecia. The present application first discovers that periostin has the activity of regulating hair follicle papilla cells, hair matrix cells and outer root sheath cells, can promote the proliferation of hair follicle papilla cells, hair matrix cells and outer root sheath cells, improve the hair induction ability of hair follicle papilla cells, and promote the hair follicle cycle transformation, hair growth and thickening, and can be applied to the preparation of preparations for treating alopecia.

The aim is to prevent and / or improve skin conditions that negatively affect skin appearance, such as wrinkles and sagging, by promoting the formation of cyclic collagen. [Solution] Screening was conducted on the expression of proteoglycan-related genes involved in proteoglycan formation, and it was found that rosehip extract or safflower extract increases the gene expression of persican and periostin, which are proteoglycan-related genes. Thus, rosehip extract or safflower extract was identified as a promoter of cyclic collagen formation.

Methods for preventing or treating periodontal disease or a dislocated traumatic tooth, for for regenerating periodontium, and for promoting expression of any one or more genes of bone sialoprotein (BSP), dentin matrix protein 1 (DMP1), cementum attachment protein (CAP), collagen type III (COL3), and periostin, are disclosed. The methods include administering an effective amount of a peptide comprising the amino acid sequence of SEQ ID NO: 29 or a pharmaceutically acceptable salt thereof or a composition containing the peptide of a salt thereof.

The invention belongs to the technical field of biomedicine and cosmetics, and particularly relates to application of periostin in preparation of a preparation for promoting hair follicle cell activity or preventing and treating alopecia. It is found for the first time that periostin has the activity of adjusting hair follicle hair papilla cells, hair parent cells and outer root sheath cells, proliferation of the hair papilla cells, the hair parent cells and the outer root sheath cells can be promoted, the hair induction capacity of the hair papilla cells is improved, hair follicle cycle transformation and hair growth and thickening are promoted, and the hair growth rate is increased. The traditional Chinese medicine composition can be used for preparing preparations for treating alopecia.