30 results about "Biological phenomenon" patented technology

Rapamycin derivatives containing substituents at C-28 in the epi orientation relative to rapamycin are disclosed, together with methods for their preparation and use, e.g. for regulation of biological phenomena in engineered cells. The compounds may contain optional additional modifications relative to rapamycin, as disclosed herein.

An improved microfluidic device and method of using the microfluidic device to measure natural motile response of a living moiety to a chemotactic agent. The invention comprises integrating microfluidic containment trenches within the microfluidic devices for cellular trapping, manipulation and real-time analysis of biological phenomena, including chemotaxis. The invention captures the design methodology for these traps, as well as the fabrication means and the associated external control mechanism that allows rapid, reversible and fully controlled changes in the chemical environment to which trapped cells are exposed.

The invention discloses a bionic object selection method based on a TRIZ theory. The method is characterized in comprising the following steps of: S1: converting an engineering practical problem into a TRIZ problem, and extracting a parameter to be improved and a deteriorated parameter; S2: independently substituting the parameter to be improved and the deteriorated parameter into an Altshuller contradiction matrix to search recommended inventive principles for solving a problem; S3: in the obtained inventive principles, analyzing the occurrence frequency of each inventive principle, sorting the inventive principles according to the descending order of the occurrence frequency, and selecting the inventive principles which are in the top N rank; and S4: comparing the inventive principles with a bionic phenomenon, selecting a biological phenomenon which is most suitable for solving the problem as a model to determine the bionic object. By use of the method, an advanced inventive problem solution, i.e., the TRIZ theory, can be introduced into a traditional bionic object selection process, the TRIZ theory is used for guiding the selection of a bionic biological prototype, and the bionic object which is most suitable for solving the problem can be efficiently selected.

Detection sequences of periostin having from 6 to 30 amino acids and which include all or part of peptide sequence SEQ ID No. 1, SEQ ID No. 2 or SEQ ID No. 3, or a homologous peptide sequence. Antibodies suitable for specifically recognizing minimally one of these detection sequences, including an anti-periostin antibody, are disclosed. Periostin detection and dosage processes and kits that use these antibodies are also disclosed. A periostin marker for early diagnosis, tracking and prognosis of pathologies that involve periostin, including benign osteolysis such as inflammatory diseases, including osteoarticular diseases, and malignant osteolysis, such as cancers with bone metastases, is provided.

A near-infrared fluorescent probe for detecting ALP is represented by Chemical 1. The fluorescent probe capable of detecting ALP can selectively detect ALP only quickly and accurately. In addition, the fluorescent probe allows monitoring of a biological phenomenon occurring in cells and tissues through noninvasive in-vivo imaging and during the early osteogenic differentiation in real time.

The invention provides a single-cell ATAC-seq data analysis method. The single-cell ATAC-seq data analysis method comprises the following steps: S1, performing data analysis and quality control on sequencing original data; S2, performing comparative analysis; S3, analyzing an insertion fragment; S4, carrying out Peak analysis on the enrichment region; S5, classifying the single-cell subgroups; S6,carrying out annotation and enrichment on the Peak related genes; S7, carrying out TF-motif analysis; S8, carrying out the subgroup accessibility difference analysis; S9, analyzing related genes of the difference accessibility sites, and annotating genes corresponding to the transcription start sites closest to the peak region where the identified difference TF-motif is located, and the like. According to the method, a comprehensive single-cell ATAC-seq data analysis process with rich analysis contents is constructed; the analysis result reveals a large amount of biological information, people can deeply excavate biological phenomena and characteristics contained in the single-cell level conveniently, the analysis process and result are visually displayed in the form of html, the analysiscontent is clear in hierarchy, the result display forms are diversified, and the readability of the report is improved.

The present invention, based on the discovery of a new biological phenomena, provides methods and compositions for use in identifying agents that modulate the phosphorylation of survivin, the interaction between survivin and p34^cdc2-cyclin B1 kinase complex, and the interaction between survivin and caspase-9. Related methods and compositions can be used to modulate survivin regulated apoptosis.

The present invention provides data analysis methods for the rapid location of subsets of large, multivariable biological datasets that are of most interest for further analysis, for the investigation of molecular modes of action of biological phenomena of interest, and for the identification of sets of data points that best distinguish between experimental groups in larger datasets as putative biomarkers. While existing methods for analyzing large biological datasets generally provide too much information to the user, or not enough, the methods of the present invention entail taking user input on what kinds of trends are of interest and then finding results that match the designated trend. In such manner, the methods of the invention allow a user to quickly pinpoint the subset of data of most interest without a concomitant loss of a large percentage of relevant information, as is typical with standard methods. The methods of the invention allow for identification of molecular entities that are involved in a biological phenomenon of interest, entities that may have otherwise gone undiscovered in a large, multivariable dataset.

A genomic variant analysis method and computer system utilizing information related to variant frequency and biological consequence to determine the relative statistical significance of each variant in given genome sequence datasets. The method and system perform both variant frequency normalization and universal pairwise variant comparisons across the given genome sequence datasets to automatically identify the likelihood of any given variant as contributing to disease process or biological phenomenon under study and organize the results into a priority ranking. The priority ranking is then used to categorize the results into biologically-related data subsets for display to indicate potential for importance.

The invention discloses application of trans-cucurbiturils iQ[7] and a preparation method. The trans-cucurbiturils iQ[7] can be used for recognizing lysine, arginine or histidine. The trans-cucurbiturils iQ[7] can effectively recognize lysine, arginine and histidine of 10 amino acids essential for human bodies, has great significances in revealing biological phenomena and process, and has wide application prospects.

Provided herein is a method for determining the temporal progression of a biological phenomenon which may affect a studied subject, the method including the steps of providing first data relative to biomarkers for the studied subject, the biomarkers being relative to the progression of the biological phenomenon, providing a numerical model, converting the first data into at least one point on the same Riemann manifold, and using a numerical model to determine a temporal progression for the biological phenomenon for the studied subject, the numerical model being a function in a Riemann manifold, the numerical model associating to values of biomarkers a temporal progression trajectory for the biological phenomenon and data relative to the dispersion of the progression trajectory for the biological phenomenon among a plurality of subjects, the numerical model being obtained by using a stochastic approximation in an expectation-maximization technique on data relative to biomarkers.

The invention provides a fast fire-extinguishing ashtray which is designed by virtue of a biological phenomenon of water-absorbing and fire-extinguishing through a frog mouth. In the invention, water in a transparent cup is communicated with the outlet of the tail of a frog so as to facilitate watering and extinguishing smoke and fire.

The invention discloses a plant pollen development specific promoter and an application thereof. The promoter has a full length of 1140 bases, and is used for starting gene expression at the plant pollen mononuclear microspore phase and at the matured pollen grain phase, wherein the expression is only carried out in tapetal layers and pollen. The promoter has good application prospects on genetic engineering breeding, is helpful for understanding biological phenomena of pollen development and male sterility, provides a new regulatory element for plant male sterility genetic engineering, and provides theoretical basis and application guidance for effective control of plant fertility performance, and rapid acquisition of production-available male sterile lines.

The invention provides a microfluidic chemotactic chip, and further provides a water eutrophication indication method based on the microfluidic chemotactic chip. The microfluidic chemotactic chip is composed of three units of the nutrient water gradient forming unit, the cell sample-injecting unit and a chemotactic effect observation chamber. The nutrient water gradient forming unit can form one of a nutrient water linear source gradient or a nutrient water point source gradient. The cell sample-injecting unit is arranged at the corresponding position according to the gradient forming mode. The microfluidic chemotactic chip has the following beneficial effects that the microfluidic chemotactic chip can accurately simulate the nutrient water linear source gradient and the nutrient water point source gradient, and a friendly testing platform is provided for chemotaxis of microalgae and bacteria to nutrient substances; and the eutrophication degree of water is evaluated from the aspect ofthe biological phenomenon instead of exploration of a physicochemical environment, the more convenient and intuitive effects are achieved, and thus supplement is provided for an existing eutrophication evaluation method based on exploration of the physicochemical environment.

Identifying pathways that are significantly impacted in a given condition is a crucial step in the understanding of the underlying biological phenomena. All approaches currently available for this purpose calculate a p-value that aims to quantify the significance of the involvement of each pathway in the given phenotype. These p-values were previously thought to be independent. Here, we show that this is not the case, and that pathways can affect each other's p-values through a “crosstalk” phenomenon that affects all major categories of existing methods. We describe a novel technique able to detect, quantify, and correct crosstalk effects, as well as identify novel independent functional modules. We assessed this technique on data from four real experiments coming from three phenotypes involving two species.