Mechanical damaging device for cell damage processing

A mechanical damage and cell technology, which is applied in the preparation of test samples, the determination/inspection of microorganisms, and material inspection products, etc.
CN101339104BInactive Publication Date: 2014-01-08HONG KONG BAPTIST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HONG KONG BAPTIST UNIV
Publication Date
2014-01-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a multi-channel mechanical damaging device which is used for damaging cells and which comprises a pin support body 1, a plurality of pins 2 which are arranged in parallel and connected with the pin support body, and a handle which is connected with the pin support body; the length the pins extending out of the pin support body can be adjusted. The pin support body is provided with a plurality of holes 5; the pins can be inserted into the holes and are suitable for the one-time suction head which can be replaced. The multi-channel mechanical damaging device can also be provided with guide components 4 which are arranged on two sides of the pin support body 1; and the angle between the guide components can be regulated. In particular, the invention provides an 8-channel mechanical damaging device which can be used in the cell injury experiment of cells which are cultured by 96-hole microplate. The invention also provides a method which uses the multi-channel mechanical damaging device to damage the cell culture and an application thereof in cell migration and the potential biological phenomena thereof.
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Description

field of invention

[0001] The invention relates to a multi-channel mechanical injury device for injuring cells. Specifically, the present invention provides an 8-channel mechanical injury device for the injury test of cells cultured in the form of a 96-well microplate. Background technique

[0002] Cell migration plays an important role in a variety of normal physiological processes. These processes include embryogenesis, angiogenesis, injury healing, intestinal mucosal injury repair, and immune defense. In some pathological conditions such as arteriosclerosis or gastrointestinal ulcers, extensive detachment of cells is often found, thus requiring immediate reconstruction of an intact monolayer for repair.

[0003] Cell migration is a complex process that requires the coordination of multiple intracellular and extracellular events, such as cytoskeletal reorganization, matrix remodeling, regulation of cell-cell adhesion, and induction of chemoattractants.

[0004] Injury a...

Claims

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