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Mechanical damaging device for cell damage processing

A mechanical damage and cell technology, which is applied in the preparation of test samples, the determination/inspection of microorganisms, and material inspection products, etc.

Inactive Publication Date: 2009-01-07
HONG KONG BAPTIST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, most damage methods require separate treatment of each sample well
There is no easy way to generate multiple and consistent mechanical injuries to confluent cells for screening multiple samples

Method used

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  • Mechanical damaging device for cell damage processing
  • Mechanical damaging device for cell damage processing
  • Mechanical damaging device for cell damage processing

Examples

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Embodiment Construction

[0055] While the invention is susceptible to various modifications and alternative forms, we have shown specific embodiments by way of example in the drawings and described in detail herein. It should be understood, however, that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention includes all modifications, equivalents and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

[0056] Such as figure 1 An 8-channel mechanical injury device according to one embodiment of the present invention is given in , which is suitable for mechanical injury to cells cultured in a 96-well microplate.

[0057] The entire appliance is made of stainless steel and can be sterilized by autoclaving. The handle 3 is a hollow stainless steel tube with a length of 12 cm, which is vertically fixed on the pin support body 1 . The pin support body 1 is provided with 8 holes 5, and the pins 2 arranged in p...

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PUM

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Abstract

The invention relates to a multi-channel mechanical damaging device which is used for damaging cells and which comprises a pin support body 1, a plurality of pins 2 which are arranged in parallel and connected with the pin support body, and a handle which is connected with the pin support body; the length the pins extending out of the pin support body can be adjusted. The pin support body is provided with a plurality of holes 5; the pins can be inserted into the holes and are suitable for the one-time suction head which can be replaced. The multi-channel mechanical damaging device can also be provided with guide components 4 which are arranged on two sides of the pin support body 1; and the angle between the guide components can be regulated. In particular, the invention provides an 8-channel mechanical damaging device which can be used in the cell injury experiment of cells which are cultured by 96-hole microplate. The invention also provides a method which uses the multi-channel mechanical damaging device to damage the cell culture and an application thereof in cell migration and the potential biological phenomena thereof.

Description

field of invention [0001] The invention relates to a multi-channel mechanical injury device for injuring cells. Specifically, the present invention provides an 8-channel mechanical injury device for the injury test of cells cultured in the form of a 96-well microplate. Background technique [0002] Cell migration plays an important role in a variety of normal physiological processes. These processes include embryogenesis, angiogenesis, injury healing, intestinal mucosal injury repair, and immune defense. In some pathological conditions such as arteriosclerosis or gastrointestinal ulcers, extensive detachment of cells is often found, thus requiring immediate reconstruction of an intact monolayer for repair. [0003] Cell migration is a complex process that requires the coordination of multiple intracellular and extracellular events, such as cytoskeletal reorganization, matrix remodeling, regulation of cell-cell adhesion, and induction of chemoattractants. [0004] Injury a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N33/48C12Q1/00
Inventor 余英杰梁佩贤麦乃岐黄岳顺
Owner HONG KONG BAPTIST UNIV
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