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Use of periostin as a novel biomarker

a biomarker and periostin technology, applied in the field of periostin, can solve the problems of increasing the incidence of ckd worldwide and emerging as a major global health threat, and achieve the effect of reducing the level of periostin

Inactive Publication Date: 2011-07-21
LOS ANGELES BIOMEDICAL RES INST AT HARBOR UCLA MEDICAL CENT
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Benefits of technology

[0007]In particular embodiments, the invention provides a method of detecting an indicator of a subject's response to treatment for renal injury or renal disease. The method entails assaying a urine sample obtained from a subject after initiation of treatment for renal injury or renal disease for periostin, wherein the level of periostin is positively correlated with the degree of renal injury or renal disease. In certain embodiments, a baseline level of periostin is measured prior to initiation of treatment for renal injury or renal disease. In a variation of such embodiments, the periostin level of the urine sample after initiation of treatment is compared to the baseline lev

Problems solved by technology

Chronic kidney disease (CKD) is increasing worldwide and is emerging as a major global health threat.

Method used

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  • Use of periostin as a novel biomarker
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  • Use of periostin as a novel biomarker

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Periostin

Novel Tissue and Urinary Biomarker of Progressive Renal Injury Induces a Coordinated Mesenchymal Phenotype in Tubular Cells

Abstract

[0085]Background: Periostin acts as an adhesion molecule during bone formation. Knowledge of expression of periostin in kidney injury is still scanty.

[0086]Methods: We investigated periostin function and expression in vitro of distal nephron tubular cells (DT), in Sprague-Dawley rats after 5 / 6 nephrectomy (Nx), in DBA2J mice after streptozotocin-induced diabetes (SZ-DM), and in the urine of chronic kidney disease (CKD) patients.

[0087]Results: Periostin was identified by microarray and confirmed by real-time PCR in renal tissue after 5 / 6Nx, and SZ-DM demonstrating generalizability of the periostin increment in renal injury. Periostin was expressed predominantly in DT and in tubule cells shed into the lumen. In affected DT after 5 / 6Nx, periostin expression appeared de novo, the epithelial cell adhesion molecule E-cadherin became undetectable, and ...

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Abstract

The invention provides, in certain embodiments, a method of detecting an indicator of renal injury or renal disease. The method entails assaying a urine sample for periostin, wherein the presence of periostin at an elevated level indicates the presence and / or degree of renal injury or renal disease. Also provided, are methods of determining progression of these conditions, as well as methods of determining subjects' response to treatment.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of U.S. provisional application No. 61 / 251,248, filed Oct. 13, 2009, which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The invention relates to the use of periostin as a marker for kidney injury and / or kidney disease.BACKGROUND OF THE INVENTION[0003]Chronic kidney disease (CKD) is increasing worldwide and is emerging as a major global health threat.[1] Accurately assessing and monitoring renal function is of critical importance in patients with CKD. Currently, kidney injury is clinically tested by serum creatinine, serum cystatin-C, or urine protein or albumin. These are markers that measure kidney functional loss, but not kidney cellular injury. A few urine proteins are also measured as markers of tubulointerstitial injury, but they are either not generally used clinically (e.g., N-acetyl-beta-D-glucosaminidase) or are experimental tests (NGAL, KIM1, Interleukin-18 (...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N30/02H01J49/26
CPCG01N33/6893G01N33/566G01N2800/34G01N2030/8831A61P13/12
Inventor ADLER, SHARONSATIRAPOJ, BANCHAWANG, YINGLAPAGE, JANINENAST, CYNTHIA C.
Owner LOS ANGELES BIOMEDICAL RES INST AT HARBOR UCLA MEDICAL CENT
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