4results about How to "Change level" patented technology

To provide a compound useful as an active ingredient of a pharmacological composition for the treatment of urinary storage symptoms, dysuria, lower urinary tract diseases, and the like. [Solution] The inventors perfected the present invention after discovering that thiazole derivatives substituted at position 2 by pyrazinylcarbonylamino are exceptional muscarinic M3 receptor positive allosteric modulators and can be expected to serve as agents for the prevention or treatment of urinary bladder and urinary tract diseases involving bladder contraction mediated by muscarinic M3 receptors. The 2-acylaminothiazole derivatives or salts thereof of the present invention can be expected to serve as agents for the prevention or treatment of urinary bladder and urinary tract diseases involving bladder contraction mediated by muscarinic M3 receptors, e.g., underactive bladder and the like.

The invention discloses application of SLC35E2B in treatment of obesity, and belongs to the technical field of biology. According to the invention, an animal model with obesity and / or related to obesity is constructed by knocking out a mouse animal model through the constructed SLC35E2B gene, changing the expression of the SLC35E2B gene in an animal body, and / or changing the level or activity of SLC35E2B protein; by means of molecular biology, enzyme immunoassay, immunohistochemical staining, oil red staining and the like, the application of the SLC35E2B gene in constructing an obesity model is researched.

This invention relates to the field of measurement and provides a shoe sole measuring mechanism, including a chassis frame and a lifting rod. A slide rail is mounted on the top surface of the chassis frame, and a baffle is also mounted on the chassis frame. A push plate is mounted on the slide rail. A slider that moves vertically is mounted on the lifting rod, and a groove is provided on the baffle. The baffle has a first scale, and the chassis frame has a second scale. The slide rail drives the push plate to move, and in conjunction with the data on the second scale, the length of the shoe sole is obtained. Then, by adjusting the lifting rod, the slider's horizontal height is changed, and in conjunction with the first scale, the height of the forefoot tilt of the shoe sole is obtained. This acquisition of key shoe sole data allows for the determination of whether there are errors in the shoe sole produced by the mold, achieving the purpose of inspection. Simultaneously, the shoe sole measuring mechanism has high flexibility, can adapt to different shoe sole models for measurement, and obtains accurate measurement data, solving the problem of cumbersome manual or simple tool measurements.

The utility model belongs to the technical field of transformer substation maintenance, and particularly relates to a transformer substation inspection and maintenance inspection device which comprises a base, wheels and hydraulic supporting feet installed at the bottom of the base, a traction frame and a hydraulic station installed on the base, a top face of the base connected with the bottom end of an adjusting mechanism, and a top end of the adjusting mechanism connected with the bottom face of an elevator. A controller and a monitoring mechanism are further installed on the bottom face of the lifter, a moving mechanism is arranged on a lifting table of the lifter and comprises two parallel fixing plates, supporting wheels are connected into the fixing plates in a rolling mode and installed on the bottom face of a workbench, and a self-locking assembly and a driving motor are arranged on the workbench. The driving motor is in transmission connection with the self-locking assembly, the self-locking assembly is meshed with the rack, and the rack is installed on a lifting platform of the elevator. The horizontal angle of the elevator is changed by automatically controlling the length of the adjusting mechanism, the workbench can stably move to the two sides of the elevator under safe driving of the self-locking assembly, and the overhaul range is effectively enlarged.