8results about How to "Change level" patented technology

The invention discloses a method for researching the influence of S100A9 on AQP4 and an influence mechanism of the S100A9, and relates to the technical field of biomedicine. Comprising the following steps: cell culture; the method comprises the following steps: inoculating U251 astroglioma cells or SD (Sprague Dawley) rat primary astroglioma cells into a culture dish, after the cells are completely adhered to the wall, replacing a culture medium containing S100A9 proteins with different concentrations, and continuously culturing for 12 hours; the cell activity is detected through CCK8; and adding a CCK8 reagent into the culture dish, incubating for a period of time, and detecting the activity of each group of cells. The invention provides a systematized and detailed research method, and the influence of the S100A9 on the AQP4 can be clarified; through the experimental steps of cell culture, CCK8 detection, Western Blot, RT-qPCR and the like, the change of the S100A9 on the expression and positioning of the AQP4 under different concentrations can be comprehensively known.

To provide a compound useful as an active ingredient of a pharmacological composition for the treatment of urinary storage symptoms, dysuria, lower urinary tract diseases, and the like. [Solution] The inventors perfected the present invention after discovering that thiazole derivatives substituted at position 2 by pyrazinylcarbonylamino are exceptional muscarinic M3 receptor positive allosteric modulators and can be expected to serve as agents for the prevention or treatment of urinary bladder and urinary tract diseases involving bladder contraction mediated by muscarinic M3 receptors. The 2-acylaminothiazole derivatives or salts thereof of the present invention can be expected to serve as agents for the prevention or treatment of urinary bladder and urinary tract diseases involving bladder contraction mediated by muscarinic M3 receptors, e.g., underactive bladder and the like.

The utility model relates to the technical field of valves, and discloses a bidirectional pilot-operated type regulating valve which comprises a main valve and a pilot-operated valve connected to the main valve, a valve seat is installed at the lower end of the main valve, a top plate is installed below the valve seat, a bottom plate is installed below the top plate, and a plurality of regulating pipes are evenly and rotatably connected to the upper surface of the bottom plate. An adjusting mechanism is arranged in the adjusting pipe, a positioning sleeve is installed outside the adjusting pipe, and a positioning mechanism is arranged at one end of the positioning sleeve; the adjusting rod in the adjusting pipe is driven to ascend and descend by rotating the adjusting pipe, so that one end of the top plate is driven to ascend and descend, the levelness of the adjusting valve is adjusted, the adjusting valve is adjusted to be in a horizontal state, and the positioning rod in the positioning mechanism is inserted into one positioning hole under the action of the spring. And the adjusting pipe cannot automatically rotate when not needing to rotate, so that unnecessary change of the levelness of the adjusted adjusting valve due to external factors is avoided.

The invention discloses application of SLC35E2B in treatment of obesity, and belongs to the technical field of biology. According to the invention, an animal model with obesity and / or related to obesity is constructed by knocking out a mouse animal model through the constructed SLC35E2B gene, changing the expression of the SLC35E2B gene in an animal body, and / or changing the level or activity of SLC35E2B protein; by means of molecular biology, enzyme immunoassay, immunohistochemical staining, oil red staining and the like, the application of the SLC35E2B gene in constructing an obesity model is researched.

The present invention belongs to the field of biomedicine technology, and specifically relates to a pyruvate derivative nano atomizer for preventing malignant transformation of pulmonary nodules and a preparation method thereof. The present invention provides a pyruvate derivative nano atomizer for preventing malignant transformation of pulmonary nodules, and the pyruvate derivative obtained after structural improvement of the commonly used anti-pulmonary disease drug sodium pyruvate is prepared as a nano atomizer. The pyruvate derivative of the present invention inhibits the expression of IL-6, reduces the damage of lung tissue, changes the levels of cytokines and chemokines in the tumor microenvironment, reduces factors that promote tumor growth, and increases factors that inhibit tumor growth, thereby inhibiting the malignant transformation of pulmonary nodules; secondly, after treatment with pyruvate derivatives, the transcriptional expression level of epithelial markers is significantly increased, and the transcriptional level of mesenchymal cell markers is inhibited, which can inhibit the epithelial cell-mesenchymal transformation process, and then achieve the purpose of inhibiting the malignant transformation of pulmonary nodules.

This invention relates to the field of measurement and provides a shoe sole measuring mechanism, including a chassis frame and a lifting rod. A slide rail is mounted on the top surface of the chassis frame, and a baffle is also mounted on the chassis frame. A push plate is mounted on the slide rail. A slider that moves vertically is mounted on the lifting rod, and a groove is provided on the baffle. The baffle has a first scale, and the chassis frame has a second scale. The slide rail drives the push plate to move, and in conjunction with the data on the second scale, the length of the shoe sole is obtained. Then, by adjusting the lifting rod, the slider's horizontal height is changed, and in conjunction with the first scale, the height of the forefoot tilt of the shoe sole is obtained. This acquisition of key shoe sole data allows for the determination of whether there are errors in the shoe sole produced by the mold, achieving the purpose of inspection. Simultaneously, the shoe sole measuring mechanism has high flexibility, can adapt to different shoe sole models for measurement, and obtains accurate measurement data, solving the problem of cumbersome manual or simple tool measurements.

The invention relates to the technical field of smoke dust collection and treatment, and provides a workshop welding smoke dust collection device which comprises a supporting assembly, a mounting base, a lead screw, a sliding base, a servo motor, a top suction cover, a storage box, a connecting pipe and an organ cover. The sliding base is connected to the lead screw in a sliding mode. The servo motor is connected with the lead screw and used for controlling the lead screw to rotate. The top suction hood is arranged on the sliding seat and is used for sucking smoke dust; the storage box is arranged on the mounting seat, an opening is formed in one side of the storage box, one end of the connecting pipe is connected with the top suction cover, the other end of the connecting pipe is communicated with the storage box, and the end, connected with the storage box, of the connecting pipe is movably arranged on the storage box; the organ cover is arranged on the storage box in a telescopic mode and used for shielding the opening of the storage box. The smoke dust collecting device has the effect of widening the application range.

The utility model belongs to the technical field of transformer substation maintenance, and particularly relates to a transformer substation inspection and maintenance inspection device which comprises a base, wheels and hydraulic supporting feet installed at the bottom of the base, a traction frame and a hydraulic station installed on the base, a top face of the base connected with the bottom end of an adjusting mechanism, and a top end of the adjusting mechanism connected with the bottom face of an elevator. A controller and a monitoring mechanism are further installed on the bottom face of the lifter, a moving mechanism is arranged on a lifting table of the lifter and comprises two parallel fixing plates, supporting wheels are connected into the fixing plates in a rolling mode and installed on the bottom face of a workbench, and a self-locking assembly and a driving motor are arranged on the workbench. The driving motor is in transmission connection with the self-locking assembly, the self-locking assembly is meshed with the rack, and the rack is installed on a lifting platform of the elevator. The horizontal angle of the elevator is changed by automatically controlling the length of the adjusting mechanism, the workbench can stably move to the two sides of the elevator under safe driving of the self-locking assembly, and the overhaul range is effectively enlarged.