44 results about "Cathepsin L" patented technology

The present invention relates to novel α-keto carbonyl calpain inhibitors for the treatment of neurodegenerative diseases and neuromuscular diseases including Duchenne Muscular Dystrophy, Becker Muscular Dystrophy and other muscular dystrophies. Disuse atrophy and general muscle wasting can also be treated. Diseases of the eye, in particular cataract, can be treated as well. Generally all conditions where elevated levels of calpains are involved can be treated. The compounds of the invention may also inhibit other thiol proteases such as cathepsin B, cathepsin H, cathepsin L, papain or the like. Multicatalytic Protease (MCP) also known as proteasome may also be inhibited and the compounds can therefore be used to treat cell proliferative diseases such as cancer, psoriasis, and restenosis. The compounds of the present invention are also inhibitors of cell damage by oxidative stress through free radicals and can be used to treat mitochondrial disorders and neurodegenerative diseases, where elevated levels of oxidative stress are involved.

The instant invention is drawn to methods useful for the treatment or the prevention of a viral infection. The methods include administering at least one compound that is an inhibitor of cathepsin L to an individual. The methods are particularly useful in individuals infected with, or at risk of infection with, SARS virus or Ebola virus. The invention also includes methods of identifying potential therapeutics for use in the methods of treatment or prevention of a viral infection.

The present invention provides means for identifying or classifying breast tumors based on the levels of nuclear cathepsin-L (CTSL) and nuclear p53 binding protein (53BP1), and methods of treating thereof.

The present invention relates to the field of biomarkers and, more specifically, to biomarkers useful in diagnosing aggressive prostate cancer. In specific embodiments, a method for diagnosing aggressive prostate cancer in a patient comprises (a) measuring the levels of one or more biomarkers in a sample collected from the patient; and (b) comparing the levels of the one or more biomarkers with predefined levels of the same biomarkers that correlate to a patient having aggressive prostate cancer and predefined levels of the same biomarkers that correlate to a patient not having aggressive prostate cancer, wherein a correlation to one of the predefined levels provides the diagnosis. In a specific embodiment, the one or more biomarkers may comprise cathepsin-L (CTSL), periostin, microfibrillar-associated protein 4 (MFAP4), collagen XII, neprilysin, clusterin, neutrophil gelatinase associated lipocalin (NGAL), epithelial cell activating molecule (EpCAM), prostate specific antigen (PSA), membrane metallo-endopeptidase (MME) and asporin (ASPN).

Methods and agents useful for modulating histone proteolysis, stem cell differentiation, and gene transcription and for treating cancer are disclosed. Antibodies or antigen binding fragments that selectively bind to histone-3 cleavage products and are useful for diagnosing cancer and monitoring a subject's response to cancer treatment are also disclosed.

This invention relates generally to the treatment of cathepsin or dynamin mediated diseases, such as proteinuria, cancer, and cognitive disease and related products. Diagnostic and other assays are also provided, as well as methods for podocyte cell gene transfer.

This invention is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin K or cathepsin L, will be therapeutically useful.

The disclosure provides methods and compositions useful for inhibiting virus requiring membrane fusion for viral entry, specifically for inhibiting severe acute respiratory syndrome coronavirus (SARS-CoV), Ebola virus (EBOV), Hendra (HeV) and Nipah (NIV) viruses by targeting Cathepsin-L (CatL) cleavages sites in the viruses' glycoproteins.

Biaryl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such biaryl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

The invention discloses a soybean protein hydrolyzate, a preparation method and applications thereof. The preparation method comprises: adding cathepsin L to soybean protein, adjusting the pH value to 5.5-8.5, stirring for 20-60 min at a room temperature, and carrying out a reaction for 2-24 h under a water bath condition of 35-42 DEG C so as to obtain the soybean protein hydrolyzate. According to the present invention, the soybean protein cathepsin L hydrolyzate can effectively improve the expression amounts of COL1A1 gene, COL1A2 gene and KPRP gene, can effectively increase the collagen I content in skin while enhance the protective function of skin, and can finally achieve effects of skin aging alleviating, skin protection improving and correspondingly improved skin moisturizing so as to achieve the purpose of skin care; with the estrogen-like effect of the soybeans, a lot of effects can be provided for the maintaining of the health of the skin; through the synergetic effect of a variety of factors and other unknown mechanisms, the soybean protein hydrolyzate of the present invention can effectively maintain the skin, and can alleviate the symptoms of various skin diseases.

The invention discloses a novel application of compound solidago decurrens spray extract dry powder in pharmacy, and finds that when the concentration of the compound solidago decurrens spray extract dry powder is 1mg/mL, the inhibition rate of the compound solidago decurrens spray extract dry powder on a new coronavirus drug target Cathepsin L protease reaches 55.6%; when inhibition rate IC50 of the compound on HIV protease is 0.38 mg/mL, and the compound can be independently used or compounded with other drugs to be used for drugs for preventing and treating novel coronavirus pneumonia and antiviral drugs.

The invention discloses application of ganodermanondiol using endonuclear cathepsin L as a target spot in pharmacy. Through in-vitro cancer cell proliferation resistance experiments and cell death andcell cycle experiments of the ganodermanondiol, it is proven that the ganodermanondiol reduces a truncated CUX1 factor (active form) by inhibiting the colorectal cancer endonuclear CL activity, thenexpression of Cyclin E2 is reduced, finally, colorectal cancer cells stay in an S phase of the cell cycle, and thus the effect of inhibiting cancer cell growth is achieved. Therefore, the ganodermanondiol can be used for preventing or curing colorectal cancer-related diseases including rectal cancer, colon cancer and related diseases, caused by rectal cancer or colon cancer, of constipation, hematochezia, abdominal pain, abdominal cramps, intestinal cancer cell infiltration and migration, and the like, and thus the ganodermanondiol is suitable for being popularized and applied.

Human cathepsin L inhibitors and probes containing a vinyl sulfonate ester moiety are described. The inhibitors are highly potent (low nM affinity), selective, and cell permeable, and can inhibit ultra-low concentration of active cathepsin L. The developed probes are highly sensitive and can detect an ultra-low amount of probe-labeled active cathespin L.

The invention provides a preparation method and application of high-gel-strength minced meat products of aquatic products. According to the invention, in the preparation of minced fish or minced shrimp gel products, by a specific high-pressure CO2 non-thermal processing treatment method, cathepsin L which causes degradation of minced fish gel can be effectively passivated so as to improve gel strength of the minced fish or minced shrimp products and improve storage stability of the products; moreover, the process adopted by the invention is simple, energy-saving and environmental-friendly, andthe high-gel-strength minced fish or minced shrimp products can be produced; and special flavors and nutritional ingredients of the minced meat products can be kept.

This present disclosure is directed to compound of Formula I and methods of using these compounds in the treatment of conditions in which modulation of a cathepsin, particularly cathepsin L, cathepsin K, and/or cathepsin B, will be therapeutically useful. Formula I: or a solvate or pharmaceutically acceptable salt thereof. Each of R1-R10 are independently selected from the group consisting of: hydrogen, alkoxy, halo, hydroxy, phosphate, phosphate salts, disodium phosphate, diphosphate dimer, diphosphate dimer salt, and sodium diphosphate dimer with at least one of R1-R10 is a phosphate or diphosphate dimer group.

The invention discloses a colloidal gold test strip for detecting a lamb fasciola hepatica infection circulating antigen, and the prepared lamb fasciola hepatica infection colloidal gold test strip can be used for detecting the lamb fasciola hepatica infection circulating antigen and has the advantages of simplicity in operation, rapidness in detection, convenience in carrying and the like in the aspect of use. The detection result is visual, easy to understand and convenient to interpret, and the kit can be used for detecting early infection of fasciola hepatica, can distinguish current infection from previous infection, and is suitable for on-site detection of clinical samples. The anti-fasciola hepatica cathepsin L monoclonal antibody ensures the specificity of the detection method. The rabbit anti-fasciola hepatica cathepsin L polyclonal antibody improves the sensitivity of the detection method.

The invention relates to a protein marker for sicca syndrome in saliva and application of the protein marker. Particularly, the invention relates to application of a protein identification reagent inpreparation of a reagent for diagnosing the sicca syndrome in a subject. Protin is selected from a combination of acylamino acid release enzyme, 1,4-glucose formyl transfer enzyme, Calumenin, C-C motif chemotatic factor ligand 28, activation-induced cytidine deaminase, alpha collagen 1 chain, carboxypeptidase D, carboxypeptidase E, cysteine proteinase inhibitor C, cathepsin L, DnaJ heat shock protein family (Hsp40) member C3, furan paired basic amino acid lyase, HtrA serine peptidase 1, kallikrein correlated peptidase 11, trypsin 3, proteasome subunit-4, proteasome subunit 9, antichymotrypsinand vimentin.