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Monoclonal antibody inhibiting tissue organ fibrosis and neovascularization, and preparation method and application thereof

A monoclonal antibody, tissue and organ technology, applied in biochemical equipment and methods, antibodies, tissue culture, etc., can solve the problems of limited efficacy of anti-fibrotic drugs, limited to animal experiments, complications and side effects, etc., to avoid Effects of cancer migration and invasion, reduction of periostin activity, and excellent binding activity

Inactive Publication Date: 2019-06-14
HE UNIV
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Problems solved by technology

At present, the most commonly used anti-fibrosis drugs in clinic have limited curative effect, and there are many complications and side effects; some other types of treatment methods are limited to the stage of animal experiments, and further clinical research is still awaited

Method used

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  • Monoclonal antibody inhibiting tissue organ fibrosis and neovascularization, and preparation method and application thereof
  • Monoclonal antibody inhibiting tissue organ fibrosis and neovascularization, and preparation method and application thereof
  • Monoclonal antibody inhibiting tissue organ fibrosis and neovascularization, and preparation method and application thereof

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Embodiment Construction

[0031] Example embodiments will now be described more fully with reference to the accompanying drawings, in which some example embodiments are shown.

[0032] An embodiment of the present invention provides a monoclonal antibody that inhibits tissue and organ fibrosis and neovascularization, and its specific antigen is a human having a nucleic acid sequence as shown in SEQ ID NO:1 and an amino acid sequence as shown in SEQ ID NO:2 periostin.

[0033] The monoclonal antibody is an anti-human periostin monoclonal antibody, and the antibody fragment of the anti-human periostin monoclonal antibody includes a single-chain variable region fragment, Fab, Fab', F(ab') or nanobody.

[0034] The antibody fragments are fused to other peptides or proteins, or modified with modifiers.

[0035] Combine below Figure 1 to Figure 6 Describe in detail the preparation method of monoclonal antibody for inhibiting tissue and organ fibrosis and neovascularization. refer to figure 1 , the embod...

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Abstract

The invention provides a monoclonal antibody inhibiting tissue organ fibrosis and neovascularization, and a preparation method and application thereof. The monoclonal antibody is an anti-human periostin monoclonal antibody, and an antibody fragment of the anti-human periostin monoclonal antibody comprises a single-chain variable region fragment, Fab, Fab', F(ab')2 or a nanobody. The anti-human periostin monoclonal antibody can specifically bind to periostin in blood and body fluid of the human body, inhibit periostin from promoting microtubule formation of cells and and have functions of preventing and treating tissue organ fibrosis and neovascularization, and is suitable for preparation of monoclonal antibody drugs for treating tissue organ fibrosis and preparation of drugs for treating tumors.

Description

technical field [0001] The present invention relates to the technical field of monoclonal antibodies, in particular to a monoclonal antibody for inhibiting tissue and organ fibrosis and neovascularization, its preparation method and application. Background technique [0002] Periostin, also known as periostin (Osteoblast-specific factor 2) or periostin, is an important endogenous cytokine involved in tissue and organ fibrosis. The human periostin gene is located on chromosome 13q13.3, the full length of the cDNA is 3187bp, the coding region is 2433bp, the human periostin protein contains 836 amino acid residues, and the molecular weight is about 93.3kDa. Periostin contains an amino-terminal secretory signal peptide, a cysteine-rich amino-terminus, four homologous repeat regions, and a hydrophilic carboxy-terminus. Periostin is a unique extracellular matrix protein whose expression is mainly concentrated in collagen-rich connective tissues under high mechanical stress in viv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/24C12N5/20A61K39/395A61P35/00
Inventor 张朔李雪娇李怀超吴骁宋庆凤海洋王硕李冰赵洪礼何向东何伟
Owner HE UNIV
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