74results about How to "Improve fusion" patented technology

An allograft spinal implant includes a generally planar superior end face, a generally planar inferior end face and a generally cylindrical sidewall. The generally cylindrical sidewall extends between the superior end face and the inferior end face. At least one of the superior end face and the inferior end face includes a plurality of concentric circular ridges.

A spinal fixation and fusion device that includes a housing with leading deep surface conforming to the posterior aspect of the intervertebral disk and trailing outer surface conforming to the anterior surface of the disk, weight bearing sides and the top and bottom surfaces with plurality of openings enabling ingrowths of bone. The device further includes a shaft running from the center of the deep surface and perpendicular to the deep surface of the housing to the center of the outer surface of the housing and affixed at least to the deep surface of the housing, and a flat metal member threaded onto the shaft with sharp leading edge which upon clockwise or counterclockwise rotation about the axis of the shaft will break the endplate, hook into the vertebra and rigidly secure the vertebra to the entire device preventing separation of the vertebra from the device during spinal motion.

An improved ceramic bone graft is provided for human implantation, particularly such as a spinal fusion cage for implantation into the inter-vertebral space between two adjacent vertebrae. The improved spinal fusion cage includes a substrate block of high strength ceramic having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block is coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fusion cage provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.

Some embodiments of the invention disclose an apparatus for achieving rapid mechanical fusion between two adjacent vertebral bodies by positioning a fusion member with one or more channels between the two vertebral bodies. Once the fusion member properly positioned, one or more needles are passed through the fusion member's channels and advanced into the marrow space of the adjacent vertebral bodies. Each needle has a lumen for receiving adhesive material and supplying said material to the marrow space of the adjacent vertebral bodies. The adhesive material is for adhesively bonding the needle to the adjacent vertebral bodies. In some embodiments, a needle also has various surface contours along its shaft, including angled teeth and backfacing ridges.

An improved spinal fixation system is provided for human implantation, including a set of screws with interconnecting rods for implantation into the pedicle and between two adjacent vertebrae or a plate with screws for fixating two adjacent vertebrae. The screws, rods, and plates include a substrate portion of high strength biocompatible material and a controlled porosity analogous to natural bone. The substrate portion may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fixation system provides a desired combination of mechanical strength together with osteoconductivity and bio-activity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fixation system may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.

An ankle arthrodesis fusion plate is provided that affords compression across the tibio-talar joint to promote bone fusion and joint stability.

Implants are formed from a multiple staged process that combines both additive and subtractive techniques. Additive techniques melt powders and fragments of a desired material, then successively layer the molten material into the desired implant shape, without compressing or remelting for homogenization of the layers, thereby producing an implant that is substantially free of pores and inclusions. Subtractive techniques refine implant surfaces to produce a bioactive roughened surface comprised of macro, micro, and nano structural features that facilitate bone growth and fusion.

An orthopedic fusion plate device has a rigid perimetral frame which embraces a pair of plates retained within the frame by a tongue and groove mechanism so that the plates can move in only a single dimension, toward and away from another. The device is intended to mitigate the effects of bone graft resorption and settling through either active or passive mechanisms.

An improved joint fusion screw for transiliac fixation has a screw head and extending therefrom an elongate hollow shaft. The hollow shaft has an externally threaded end portion extending to a tip end and a non-externally threaded shank portion having a plurality of window openings. At or near the tip end is a start of a thread with a bone cutting flute. The bone cutting flute has a cutting edge on a circumferential exterior of the threaded tip to cut bone and directs the cut bone internally into a bone receiving opening in the hollow shaft directly in front of the cutting flute. The cutting edge lies at the start of the thread extending radially above the bone receiving opening at least partially overhanging the opening configured to cut bone.

The invention relates to methods and materials for enhancing muscle mass or for the treatment of muscle disease in a subject, comprising introducing a cell which has a lower than normal level of myostatin signalling, into the subject.

The invention discloses a full-position connecting pipe and safety end circular seam welding method achieved through tungsten electrode inert gas arc welding. According to the method, nickel base alloy serves as an isolating layer to carry out machining on a connecting pipe and a safety end so that a welding groove can be formed by the connecting pipe and the safety end during assembling, and the welding groove is welded. A plurality of weld beads are welded during welding, the bottom end of a part to be welded is arced during welding, spin welding is carried out along one side of the part to be welded to the top end of the part to be welded, arcing is stopped, the bottom end of the part to be welded is arced again, spin welding is carried out along the other side of the part to be welded to the top end of the part to be welded, and arcing is stopped. When the welding groove is a double-faced U-shaped narrow gap groove, an outer groove is welded but not completely welded, back chipping and complete welding are carried out on an inner groove, and then complete welding is carried out on the outer groove. When the welding groove is a single-faced narrow gap groove, the groove is completely welded, a cushion plate is removed, and back chipping is carried out.

A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.

A pharmaceutical being used for treating HIV infection is provided which has the following peptide sequence: X-SWETWEREIENYTKQIYKILEESQQDRN-EKDRNEKDLLE-Z, where S is Serine, W is Trytophan, E is Glutamate, T is Threonine, R is Argine, I is Isoleucine, N is Asparagine, Y is Tyrosine, K is Lysine, Q is Glutamine, L is Leucine, D is Aspartic acid, X is amino group, acetyl-hydrophobic group, or macromolecule carrier group, Z is carboxyl group, amino group, amido group, tert-nutyloxycarbonyl group, hydrophobic group, or macromolecule carrier group. The drug inhibits strongly the infection of HIV.

In an information processing apparatus having a service mode for a service person to carry out maintenance of the apparatus enters for carrying out the maintenance, a registration page is provided for registering the service person as a service person in charge of the maintenance of the apparatus, and an input page is provided for inputting authentication information required for the service person that is registered in the registration page as a person in charge of the maintenance of the apparatus to enter the service mode.

Various porous implantable interbody or spinal fusion devices, which may be formed of metal, metal alloy or polymer are provided. These porous implantable interbody devices may be engineered to have a porous network or scaffold structure for repairing and/or replacing damaged bone segments in the spine while allowing better fusion for improved bone healing and bone regrowth.