Solid effervescent mixture for the oral absorption

A technology for oral absorption and effervescent preparations, applied in the directions of anti-inflammatory agents, antidote, non-central analgesics, etc., can solve the problems of low bioavailability, slow onset of drug effect, etc. Fast absorption effect

Inactive Publication Date: 2010-12-22
无锡健而乐医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a solid solution for oral absorption with fast onset of drug effect and high bioavailability for the shortcomings of traditional gastrointestinal absorption oral anti-alcohol preparation effervescent wine preparation

Method used

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  • Solid effervescent mixture for the oral absorption
  • Solid effervescent mixture for the oral absorption
  • Solid effervescent mixture for the oral absorption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: oral absorption solid hangover effervescent preparation, the weight percentage of each component is:

[0057] Citric Acid 5%, Sodium Bicarbonate 35%, Calcium Carbonate 15%, Vitamin C 0.2%, Glucuron Lactone 0.3%, Green Tea Extract 0.5%, PEG 35%, Aspartame 0.3%, Peppermint Flavor 0.6%, 4% sorbitol, 1% micronized silica gel, and the rest are colorants.

[0058] Preparation:

[0059] a. The above-mentioned citric acid, sodium bicarbonate, calcium carbonate, vitamin C, glucuronolactone, and sorbitol were pulverized respectively through an 80-mesh sieve;

[0060] b. Mix citric acid, sorbitol and PEG in proportion, heat to 65°C to melt, granulate through a 20-mesh sieve, cool and dry, and set aside;

[0061] c. Mix sodium bicarbonate, calcium carbonate and PEG in proportion, heat to 65°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside;

[0062] d. Mix vitamin C, glucuronolactone, green tea extract and PEG in proportion, heat to...

Embodiment 2

[0064] Embodiment 2: oral absorption solid hangover effervescent preparation, the weight percentage of each component is:

[0065] Malic acid 50%, sodium carbonate 5%, glucuronolactone 5%, hawthorn extract 35%, PEG 0.5%, stevioside 0.3%, hawthorn powder 0.9%, PVP 3%, magnesium stearate 0.15%, the rest is Colorant.

[0066] Preparation:

[0067] a. The above-mentioned malic acid, sodium carbonate, glucuronolactone, and hawthorn extract were respectively crushed through an 80-mesh sieve;

[0068] b. Mix malic acid and PEG in proportion, heat to 65°C to melt, granulate through a 20-mesh sieve, cool and dry, and set aside;

[0069] c. Mix sodium carbonate and PEG in proportion, heat to 65°C to melt, granulate through a 20-mesh sieve, cool and dry, and set aside;

[0070] d. Mix glucuronolactone, hawthorn extract and PEG in proportion, heat to 65°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside;

[0071] e. Fully mix the components obtained in ...

Embodiment 3

[0072] Embodiment 3: oral absorption solid hangover effervescent preparation, the weight percentage of each component is:

[0073] Tartaric acid 10%, calcium carbonate 30%, vitamin C 8%, natural caffeine 2%, orange extract 10%, panthenol 16%, PEG 15%, spicy powder 0.8%, mannitol 7%, stevioside 0.2% , 0.95% talcum powder, and the rest are colorants.

[0074] Preparation:

[0075] a. The above-mentioned tartaric acid, calcium carbonate, vitamin C, natural caffeine, Fructus Fructus Fructus Fructus Extract, mannitol are pulverized respectively through 80 mesh sieves;

[0076] b. Mix tartaric acid with panthenol and PEG in proportion, heat to 90°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside;

[0077] c. Mix calcium carbonate with panthenol and PEG in proportion, heat to 90°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside;

[0078] d. Mix vitamin C, natural caffeine, orange extract, mannitol, panthenol and PEG...

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Abstract

The invention relates to an effervescent mixture, specifically relates to a solid effervescent mixture for the oral absorption and preparation method thereof. The invention comprises the alkalic component of a mixture consisting one or more than one of alkali metal carbonate, alkali metal bicarbonate, alkaline earth metal carbonate or pearl powder; the acid component of a mixture consisting one or more than one of tartaric acid, citric acid, adipic acid, fumaric acid, maleic acid, malic acid, folic acid andacid phosphate; The medical component of a mixture consisting of one or more than one of vitamin C, glucurolactone, natural caffeine, haw extract, green tea extract, hovenia acerba extract, semen myristicae extract, Poria cocos extract, Amomum tsao-ko extract, root of kudzu vine extract, spina date seed extract, cassia twig extract, Lesser Galangal Rhizome extract, and chrysanthemum extract; the wrapper and auxiliary material of a mixture consisting one or more than one of polyethylene glycol (PEG), panthenol and glycerin monostearate. The invention comprises, by weight, 5-50% of alkalic component; 5-50% of acid component; 1-40% of medical component; 0.5-35% of wrapper; 1-10% of auxiliary material. The invention has advantages of being fast in effect, and convenient in medicine taking and carrying.

Description

technical field [0001] The present invention relates to an effervescent preparation, in particular to a solid effervescent preparation, especially a kind of anti-alcoholic anti-alcoholic preparation that can be absorbed into the blood circulation system through the oral cavity, gums, sublingual mucous membranes and other parts after oral administration without being dissolved in water first. Effervescent preparation and preparation method thereof. technical background [0002] At present, traditional oral drug dosage forms, including tablets, capsules, oral liquids, etc., are absorbed into the blood circulation system through the gastrointestinal tract to exert their drug effects, and the onset time is usually more than 30 minutes; before the drug enters the blood circulation system, it produces The first-pass effect of the liver and the stimulation of the gastrointestinal mucosa by the drug, various biological enzymes in the gastrointestinal tract and bile will affect the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/46A61K9/16A61K9/68A61K31/375A61K31/522A61K31/7048A61K36/076A61K36/185A61K36/28A61K36/488A61K36/54A61K36/725A61K36/734A61K36/82A61K36/9062A61K36/9064A61K47/34A61K47/18A61K47/14A61P39/00A23L33/00
CPCA61K9/0007A61K31/00A61K9/0056A61P1/02A61P1/14A61P1/16A61P21/00A61P25/00A61P25/34A61P29/00A61P37/04A61P39/00A61P39/02A61P39/06
Inventor 刘双华
Owner 无锡健而乐医药科技有限公司
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