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31results about How to "Reduce research costs" patented technology

Testing device and method for simulating migration and transformation of pollutants in underground water

The invention discloses a test device for simulating migration and transformation of pollutants in underground water. The test device comprises a sand box, a water supply system and a drainage system, the sandbox is internally divided into a water inlet well, a water outlet well and a sand tank; the water inlet well adjusts water head height and is connected with the water supply system; the water supply system, the water inlet well and a passage therebetween are sealed; the sand tank simulates an aquifer soil body and is filled with a soil sample or quartz sand; the water outlet well is connected with a drainage system; the water inlet well and the water outlet well are separated from the sand tank through partition plates, a plurality of through holes are formed in the partition plates, and filter cloth is arranged on the surfaces of the partition plates facing the sand tank. A plurality of pore water sampling holes are formed in the front upper part of the sand tank; a plurality of underground water sampling holes are formed in the front lower part of the sand tank; a plurality of pressure measuring holes connected with a pressure measuring pipe or inserted into a soil moisture tensiometer are formed behind the sand tank; water of the water supply system enters the water inlet well and then permeates into the sand tank filler, water in the filler permeates into the water outlet well, and water of the water outlet well is discharged from the drainage system. Compared with a field test, the material and time cost is reduced.
Owner:NANKAI UNIV

Research method of Tarim red deer population spatial distribution pattern

PendingCN119600476Areduce research costsavoid interferenceCharging stationsBiological modelsAnimal ecologyUncrewed vehicle
The invention discloses a method for researching a Tarim red deer population spatial distribution pattern in the field of animal ecology. The method comprises the following steps: step 1, analyzing Tarim red deer wild population distribution characteristics; 2, analyzing forest environment characteristics of the Tarim red deer wild population habitat; 3, analyzing the spatial correlation between the Tarim red deer wild population distribution and the biological environment factors; step 4, tracking and analyzing the motion trail of the Tarim red deer; 5, analyzing the influence of habitat space distribution and abiotic factors on Tarim red deer wild population distribution; and step 6, evaluating habitat suitability of the Tarim red deer wild population. The method is reliable and accurate, and provides data support for construction of a Tarim red deer wild population protected area in the future by analyzing a Tarim red deer wild population space distribution pattern and habitat forest environment characteristics, using the unmanned aerial vehicle to track a motion trail of a red deer group, evaluating habitat suitability of a habitat and evaluating a potential suitable area of the habitat.
Owner:INST OF AFFORESTATION & DESERTIFICATION PREVENTION & CONTROL XINJIANG ACADEMY OF FOREST SCI

Method for predicting flow velocity along floating vegetation river course

The application discloses a method for predicting the flow velocity along the course of a river with floating vegetation, and the river with floating vegetation is divided along the water flow direction of the river according to the flow regulation distance, and the water flow direction velocity prediction model of the river with floating vegetation is constructed to realize the prediction of the flow velocity along the course of the river, so as to provide a theoretical basis for further research on the water flow, sediment movement characteristics and riverbed evolution of the natural river and lake with floating vegetation.
Owner:SICHUAN UNIV

Culture medium system for inducing airway stem cells to differentiate into airway epithelial cells based on ALI and application of culture medium system

The invention discloses a culture medium system for inducing airway stem cells to differentiate into airway epithelial cells based on ALI and application of the culture medium system. Belongs to the technical field of ALI culture. By means of the culture medium system, the airway stem cells can be efficiently and stably induced to be differentiated into multiple types of airway epithelial cells in the ALI culture process, and particularly, the generated cilia cells are close to the physiological state in vivo. Compared with an imported culture medium, the culture medium has the advantages of definite components, high batch stability, low cost and simple preparation method; the generated airway epithelial cells have a plurality of cell lineages, can well simulate airway epithelium, and show forms and functional characteristics similar to those of an in-vivo airway. According to the system, a respiratory tract epithelium-induced ALI culture system is remarkably improved, the research cost is reduced, a preferable scheme is provided for scholars engaged in studying physiological and pathological characteristics of respiratory tract epithelial cells based on ALI, and researchers are helped to establish a stable repeatable airway model.
Owner:INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI

Large model agent autonomous iterative optimization method and system based on red-blue confrontation

PendingCN121960548AImprove screening efficiencyEnsure uniform executionSemantic analysisArtificial lifeSales intelligenceFinancial transaction
The invention provides a red-blue confrontation-based large model agent autonomous iterative optimization method and system, and the method comprises the steps: building a customer agent as a blue party based on a large language model, obtaining user data from a plurality of channels, generating diversified customer portrait data, generating a dialogue test set containing diversified customer consultation test data, and carrying out the calculation of the dialogue test set. Taking the data as adversarial data for iterative optimization of the model; the method comprises the following steps: constructing a sales agent as a red party by using a preset first version prompt word, starting the red party and a blue party to carry out dialogue based on adversarial data, limiting a maximum dialogue round or taking a transaction conclusion as an exit condition, and carrying out quality inspection scoring and prompt word optimization direction prompting on the sales agent through a plurality of evaluation dimensions; inputting the first version cue word and the cue word optimization direction to a sales agent to obtain an optimized sales agent cue word; and repeating until the quality inspection score converges, and completing the iterative optimization process of the sales agent. According to the method, the sales conversion rate is remarkably improved, and the manual optimization cost is greatly reduced.
Owner:PACHIRA TIMES (ZHUHAI HENGQIN) INFORMATION TECH CO LTD

An equidistant sampling device suitable for research on soil pollutants in agricultural land

This utility model relates to the field of soil research technology and discloses an equidistant sampling device suitable for the study of soil pollutants in agricultural land. It includes a support plate with a scale fixedly connected to its top. Two I-shaped grooves are formed at the top of the support plate, and two I-shaped sliders are slidably connected to the inner walls of the two grooves. Two pedals are fixedly connected to the tops of the two sliders. The operator first determines the sampling interval according to the research requirements. Then, the operating parameters of the bidirectional motor, such as speed and direction of rotation, are set via the control panel. After starting the bidirectional motor, its output drives a bidirectional screw to rotate. Due to the bidirectional thread characteristic of the bidirectional screw, the two moving sleeves connected to the surface of the bidirectional screw will move in opposite directions at equidistant intervals along the screw. The operator can then observe the position of the pointer on the scale.
Owner:WUHAN ZHIHUI GUOSHI TESTING TECH CO LTD

Fluid action induced coal rock strain method based on dynamic ensemble simulation

PendingCN121762350AAccurately reveal microscopic mechanismsshorten the research cycleFuel testingMaterial strength using tensile/compressive forcesEnsemble simulationMechanics
The invention relates to the technical field of coal rock, in particular to a fluid action induced coal rock strain method based on dynamic ensemble simulation, which comprises the following steps: constructing a coal rock macromolecular model; determining the type of fluid to be researched; simulating the coal rock macromolecular models of different fluid types by utilizing a dynamic ensemble; and constructing a coal rock strain model induced by different fluid effects. The method solves the problems that existing molecular dynamics simulation lacks reasonable selection and application of a dynamics ensemble, and the strain condition of coal rock under the actual working condition is difficult to accurately simulate.
Owner:CHANGZHOU UNIV

A black light experiment cooperative control system and method based on multi-agent cooperative decision-making

PendingCN122592877ABreak through the standardization precipitationBreak through cross-organizational reuse
The present application relates to the technical field of artificial intelligence and black light experiment collaborative control, in particular to a black light experiment collaborative control system and method based on multi-agent collaborative decision. It includes multi-agent collaborative decision module, digital twin and protocol conversion module, black light experiment execution module, human-computer interaction quality control module and result analysis and skill sedimentation module. Through the cooperation of the five modules of multi-agent collaborative decision, digital twin and protocol conversion, multi-actuator arrangement, human-computer interaction quality control, result analysis and skill sedimentation, end-to-end full closed loop from natural language scientific research task input to 7*24 hours unattended experiment execution, full-dimensional data quality control to structured skill sedimentation reuse is realized. The pain points of high dependence on traditional scientific research manpower, poor experimental reproducibility and difficult knowledge inheritance are solved, and the scientific research efficiency and achievement quality are greatly improved.
Owner:HANGZHOU CHANGSU BIOTECHNOLOGY CO LTD

Polypeptide membrane anchoring high-throughput screening method for gpcrs

PendingCN122648487AInexpensive to synthesizereduce research costsHigh-Throughput Screening MethodsTobacco etch virus protease
The polypeptide membrane anchoring high-throughput screening method for GPCR is that the C terminal of GPCR is connected with tetracycline-controlled transcriptional activator (tTA) through tobacco etch virus protease substrate sequence (TEV-Substrate). When GPCR is combined with the membrane anchoring polypeptide, the TEV protease cuts the substrate to release tTA, activates the expression of luciferase reporter gene (Luc), and the cell expressing luciferase can detect the production amount of oxidized luciferin by using an enzyme label instrument, so that the accurate screening of the targeted polypeptide compound is realized. The screening method provided by the application can quickly screen the polypeptide combined with GPCR, is not limited to the screening of only a certain signal path in the traditional GPCR function detection, and can realize the high-throughput screening of the polypeptide and GPCR target by combining the luciferase reporter gene.
Owner:CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE

Combined vibration device

PendingCN121954380AStructural weight well matchedGood match of modal propertiesVibration testingServomechanismServo
The invention belongs to the technical field of structural design of test devices, and discloses a servo mechanism combined vibration device which comprises a support I, a support II, a support III, a supporting frame, a reinforcing column, a reinforcing plate, a supporting cylinder, a base I, a base II and the like. The reinforcing column is connected with a support I and a support II, and independent transmission mechanisms can be installed on the support I and the support II. The support II and the support III are connected through a reinforcing plate, and a control assembly can be installed on the reinforcing plate. A supporting frame is installed between the support II and the support III, and the transmission mechanism and the control assembly can be integrated together through the supporting frame, a reinforcing column and a reinforcing plate and can also be installed separately and independently. The supporting cylinders at the two ends of the tool are used for meeting different clamp connector requirements. The split-type servo mechanism can be integrated into a cabin section by simulating a projectile body structure form, so that the disassembly and assembly frequency in the production circulation process is reduced.
Owner:CHINA AIR TO AIR MISSILE INST

Close-linkage SSR (simple sequence repeat) marker and application thereof in QTL (quantitative trait loci) positioning of barley helminthosporium leaf spot

The invention provides a closely linked SSR marker and application thereof in barley helminthosporium leaf spot resistant QTL positioning, and relates to the technical field of molecular marker assisted breeding. The two QTL sites closely linked with the helminthosporium leaf spot resistance character are successfully positioned through the SSR marker technology, the accuracy of the SSR marker is further verified, the positioning work of the barley helminthosporium leaf spot resistance QTL is successfully completed within a short time by utilizing the SSR marker technology, timely and effective support is provided for disease-resistant breeding, and the method has the advantages of being high in practicability and high in practicability. According to the calculated QTL effect, the position of the QTL on the genetic map is determined, fine positioning of the QTL can be achieved, cross breeding is conducted through the screened helminthosporium leaf spot resistant genotype, a new helminthosporium leaf spot resistant barley variety can be more quickly cultivated in combination with a traditional breeding method, and the strategy of the modern genetic technology and the traditional breeding method is combined.
Owner:INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI +1

Carbon-based nitrogen-rich energetic material crystal structure design method based on functional group assembly under high pressure

The invention discloses a carbon-based nitrogen-rich energetic material crystal structure design method based on functional group assembly under high pressure. The method comprises the following steps: (1) carrying out structural assembly on a CN4 functional group unit and an N2 structural unit; (2) structure optimization is carried out under high pressure, and the structure with the lowest energy under each component is reserved; (3) calculating formation energy to obtain a convex hull graph under high pressure; (4) high-pressure stability evaluation: eliminating unstable structures, and performing high-pressure synthesis route evaluation on stable structures; (5) obtaining a structural phase under normal pressure; (6) performing normal-pressure physical property evaluation, eliminating structures with poor normal-pressure stability, and performing performance evaluation on structures with good stability; (7) performance evaluation: eliminating structures with poor performance; and (8) obtaining a structure with good performance, namely obtaining the target carbon-based nitrogen-rich energetic material. According to the method, the problem that a stable phase is difficult to find by searching a crystal structure of the carbon-based nitrogen-rich energetic material is solved, the carbon-based nitrogen-rich energetic material of which the mass density is higher than 2.5 g / cm < 3 > and the energy density is higher than 7.2 kJ / g is obtained, and the performance limit of the known carbon-based nitrogen-rich energetic material is broken through.
Owner:QUFU NORMAL UNIV

Preparation method of soybean polypeptide with antioxidant and antagonistic lead damage effects

The present application relates to a kind of soybean polypeptide preparation method with antioxidant and antagonistic lead damage effect.The soybean polypeptide prepared in the present application has good DPPH free radical clearance rate, ABTS free radical clearance rate and Fe3+ reduction capacity in vitro;It can also alleviate the case that the body weight of mouse is slowly increased due to lead exposure, improve the learning and memory ability of lead exposure mouse, alleviate the organ damage of mouse caused by lead exposure, enhance the level of reduced glutathione, superoxide dismutase and catalase of organism, and alleviate the abnormal increase of malondialdehyde caused by lead exposure.The soybean polypeptide prepared in the present application has good in vitro antioxidant capacity, and has antagonistic effect on oxidative stress caused by lead exposure mouse, and can be used as non-toxic and harmless natural antioxidant.For the development of natural antioxidant food, it has far-reaching application prospect, and also provides a new feasible idea for the combined application of bioinformatics technology and traditional enzymatic technology.
Owner:TIANJIN UNIV OF SCI & TECH +1

Test strip and kit for detecting lung cancer autoantibody and application

The embodiment of the invention belongs to the technical field of detection, and relates to a test strip and a kit for detecting lung cancer autoantibodies and application, the test strip comprises a first colloidal gold test paper, a second colloidal gold test paper, a third colloidal gold test paper, a fourth colloidal gold test paper, a fifth colloidal gold test paper, a sixth colloidal gold test paper and a seventh colloidal gold test paper, a p53 protein gold marker and a p53 recombinant antigen are arranged on the first colloidal gold test paper; a PGP9.5 protein gold marker and a PGP9.5 recombinant antigen are arranged on the second colloidal gold test paper; an SOX2 protein gold marker and an SOX2 recombinant antigen are arranged on the third colloidal gold test paper; a GAGE7 protein gold marker and a GAGE7 recombinant antigen are arranged on the fourth colloidal gold test paper; a GBU4-5 protein gold marker and a GBU4-5 recombinant antigen are arranged on the fifth colloidal gold test paper; an MAGEA1 protein gold marker and an MAGEA1 recombinant antigen are arranged on the sixth colloidal gold test paper; and a CAGE protein gold marker and a CAGE recombinant antigen are arranged on the seventh colloidal gold test paper. According to the invention, instant detection is realized while the detection sensitivity is ensured.
Owner:DAAN GENE CO LTD

High-voltage electrified body-electrified worker gap corona development model and pilot start judgment method

The invention discloses a high-voltage electrified body-hot-line worker gap corona development model and a pilot start judgment method, and the method comprises the steps: carrying out the judgment according to the discharge physical process of a hot-line work combination gap, based on a long air gap discharge corona development model, a pilot start criterion and the like; a high-voltage electrified body-electrified worker gap corona development model is established, and a pilot initial judgment method corresponding to the model is provided. The model can simulate the corona development physical process of the gap between the high-voltage electrified body and the live working personnel under the operation impulse voltage by respectively simulating the potentials of the high-voltage electrified body and the live working personnel in the discharge development process, so as to calculate the regional space charge quantity of the gap corona region and judge whether the pilot in the gap is started or not; and a new model and a new method can be provided for live-line work combined gap discharge simulation research.
Owner:HUNAN UNIV +1

Novel agar salt bridge type electrical stimulation cell culture device

The utility model discloses a novel agar salt bridge type electrical stimulation cell culture device which comprises a base, a top cover, a salt bridge positioning module and an electrical stimulation module, the top cover is mounted on the base, and a plurality of groups of optical observation windows are arranged on the top cover; each group of salt bridge positioning modules comprises a base and a salt bridge positioning buckle; an adjusting mechanism is arranged between the salt bridge positioning buckle and the base, and the adjusting mechanism is used for adjusting the height of the salt bridge positioning buckle; the electrical stimulation module comprises a PCB (Printed Circuit Board) and a plurality of groups of electrode columns; the PCB is mounted on the top cover; and the electrode column is arranged on the PCB through a threaded connection structure. The novel agar salt bridge type electrical stimulation cell culture device disclosed by the utility model can be matched with a standard commercial cell culture dish for use, the universality is wider, an experimenter can conveniently observe the cell / tissue state in the commercial cell culture dish, and meanwhile, the electric field intensity gradient can be conveniently adjusted.
Owner:GUANGDONG UNIV OF TECH

Hysteresis loop data extraction method, device and prediction system based on image recognition

The present invention discloses a method, device and prediction system for extracting hysteresis loop data based on image recognition, and relates to the fields of material science and electronic engineering technology. The present invention comprises: receiving hysteresis loop image data, and preprocessing the image data; using the DB algorithm model that has been pre-trained on the paddleOCR platform to locate the coordinate axis text in the hysteresis loop image; using the CRNN algorithm model that has been pre-trained on the paddleOCR platform to identify the located coordinate axis text content, and extract the coordinate axis data; binarizing the image data, and determining the border position information of the hysteresis loop by calculating the sum of the image rows and columns. The present invention can directly extract key data from a hysteresis loop image with noise, and use these data to accurately predict the hysteresis loop, significantly reducing the dependence on expensive experimental equipment, and improving the efficiency and accuracy of data processing.
Owner:SOUTHEAST UNIV

A method for evaluating GBM drug delivery system in vitro based on tumor organ chip

PendingCN122278990AThe result is accurate and reliableImprove reliabilityEfficacyDrug administration
This invention belongs to the field of biomedical technology and discloses an in vitro evaluation method for GBM drug delivery systems based on tumor organoid chips. This method uses a PDMS tumor organoid chip as a carrier, co-culturing GBM cells and human umbilical vein endothelial cells to localize and culture GBM cells within the chip chamber. A biomimetic blood-brain barrier is constructed within the microchannels, and a perfusion system continuously maintains the cell growth microenvironment. After in vitro drug administration to the test drug delivery system, its anti-GBM effect is quantitatively detected from three dimensions: proliferation, invasion, and spheroidization. This invention can highly simulate the in vivo GBM tumor microenvironment and blood-brain barrier structure, achieving precise, real-time, and dynamic in vitro efficacy evaluation, while significantly reducing reliance on animal experiments, improving the reliability of results and experimental throughput. It provides an efficient and standardized platform for preclinical screening and mechanism of action research of anti-GBM drug delivery systems, and has significant scientific research value and clinical translational significance.
Owner:NINGBO MEDICAL CENT LIHUILI HOSPITACL

A bionic lymph node organoid, a construction method and application thereof

The present application relates to a kind of bionic lymph node organoids and its construction method, the organoids include in three-dimensional space: one B cell-rich core region;And one T cell-rich region, it is at least partially wrapped in the core region in space;Wherein, the core region can be differentiated to form the light area and dark area with structural difference in response to external stimulation.The method includes preparing first bioink and second bioink, the first bioink contains B lymphocyte, and the second bioink contains T lymphocyte;Using the first and second bioink, the organoid prototype with the spatial structure of T cell-rich region wrapping B cell-rich region is formed by three-dimensional construction technology;The organoid prototype is solidified to stabilize its structure;External stimulation is applied to the structure after solidification, and the B cell-rich region is differentiated to form light area and dark area.
Owner:BEIJING SCI & TECH PATENT OFFICE

An airplane air water-throwing simulation analysis method and device based on VOF-DPM

This invention relates to the field of simulation and computation technology, specifically to a simulation analysis method and apparatus for aircraft in-flight water drop based on VOF-DPM. It addresses the problems of actual flight tests being significantly affected by weather, incurring high manpower and material costs, and difficulties in measuring local dynamic physical quantities, as well as the time-consuming nature and scale-effect errors in scaled-down model tests. The method includes setting up a flow field domain, dividing it into an air domain and a water domain; spatially discretizing the flow field domain based on a Cartesian octree grid; effectively capturing the free interface of the gas-liquid two-phase flow using a VOF-DPM combined h-type refined adaptive grid; and progressively refining the local grid of the Cartesian octree grid, with a grid refinement standard of 2 in each direction. x The physical parameters of the flow field are initialized; the position and shape of the phase interface are captured using the VOF method based on grid resolution; and the free-moving droplets are simulated to realize the simulation analysis of airborne water droplets from aircraft.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS

Red blood cell refrigeration house and optimization design method thereof

The invention discloses a red blood cell refrigeration house optimization design method, and relates to the technical field of refrigeration equipment, and the method comprises the steps: setting constraint conditions of each factor of a red blood cell refrigeration house, each factor comprising the specific surface area of the red blood cell refrigeration house, the variable cross-section height, the air cooler position, the internal heat source position, the air cooler air supply temperature and the air supply speed; based on the level number of each factor, acquiring a factor level table, and designing an orthogonal experiment working condition; thermal performance evaluation indexes under different working conditions are calculated, and orthogonal simulation results under different working conditions are obtained; based on the orthogonal simulation result, performing range analysis on the thermal performance evaluation index under the orthogonal experiment working condition to obtain an orthogonal experiment calculation result; and an orthogonal experiment calculation result is analyzed to obtain an optimal combination working condition of each factor, so that unnecessary energy loss is reduced, temperature uniformity and velocity field distribution are optimized, and the stability of a storage environment is ensured.
Owner:NANJING NORMAL UNIVERSITY +1

A provenance analysis method based on measuring Dpar value

The present invention provides a provenance analysis method based on measuring Dpar value. By measuring the Dpar value of the fission track of the sedimentary area and the source area sample; then using the multidimensional scaling analysis method to group the obtained Dpar value, obtain grouped data, use the Dpar value as a parameter, match the sedimentary area and the source area with the same Dpar value characteristics of the grouped data to construct a sedimentary area-source area coupling model, it is possible to accurately delineate the source area and its rock type, determine the source of the sediment, and make the provenance analysis more accurate and reliable. Moreover, the provenance analysis method of the present invention only needs to measure the Dpar value of the sample to accurately obtain the provenance analysis result, and there is no need to perform thermal neutron irradiation on the sample during the measurement of the Dpar value, and it takes a short time to obtain the Dpar value, which effectively solves the defects of sending the analysis sample to a nuclear reactor for thermal neutron irradiation or irradiation for a long time and radioactivity in the process of traditional determination of fission track age for provenance analysis.
Owner:CHINA UNIV OF GEOSCIENCES (WUHAN)

Electric pulse processing device and method

PendingCN121852838Aobserve clearlyEnsure processing uniformityMetallic materialsConductive materials
The invention provides an electric pulse processing device and method, and belongs to the technical field of material processing, the electric pulse processing device comprises a base, two clamping pieces, a power supply, a pulse generator and a resistance regulator; two first fixing parts and a second fixing part are arranged at the upper end of the base, the base is made of an insulating material, and a sample is mounted on the second fixing part; the clamping piece is fixedly connected to the two first fixing parts; the clamping piece is a piece made of a conductive material, and two clamping ends of the clamping piece are respectively clamped on a sample; the power supply is connected with the two clamping pieces and forms a conductive path with the sample; the pulse generator is connected to the conductive path; a control switch connected to the conductive path is arranged on the pulse generator; the resistance regulator is connected to the conductive path and used for regulating the current of the conductive path. According to the electric pulse treatment device, the performance improvement effect of the metal material can be improved, and an electron microscope can be easily used for micromechanism research.
Owner:HEBEI UNIV OF SCI & TECH

Crystal structure design and physical property evaluation method of magnetic copper-based nitrogen-rich energetic material

The invention discloses a crystal structure design and physical property evaluation method of a magnetic copper-based nitrogen-rich energetic material. The method comprises the following steps: assembling # imgabs 0 #, # imgabs 1 #, # imgabs 2 # and # imgabs 3 # anions and a Cu < 2 + > cation structure; optimizing high-throughput structures in the same spinning direction, and screening 10 structures with the lowest energy under each component; optimizing structures in different spin directions, and determining magnetic sequence characteristics and magnetic moments of 10 structures with the lowest energy under each component; performing stability evaluation on the structures, eliminating unstable structures, and performing energetic property evaluation on stable structures; evaluating energetic properties, eliminating structures with poor properties, and taking structures with good properties as crystal structures of the target copper-based nitrogen-rich energetic material; and carrying out magnetic mechanism analysis and comprehensive physical property analysis on the target copper-based nitrogen-rich energetic material. The technical problem of predicting the crystal structure of the magnetic copper-based nitrogen-rich energetic material is solved. The stable crystal structure of the copper-based nitrogen-rich energetic material is obtained, the energy density limit of the known copper-based nitrogen-rich energetic material is broken through, and the physical property evaluation method of the energetic material containing the spinning electrons is illustrated. The method is of great significance to the design of a nitrogen-rich energetic material crystal structure containing spin electrons.
Owner:QUFU NORMAL UNIV

Simulation model construction method for stimulating deep brain area by electromagnetic waves

PendingCN121960040AAvoid non-specific stimulationAchieve specific activationDesign optimisation/simulationMulti-objective optimisationElement modelElectro stimulation
The invention relates to the technical field of computer simulation, and provides a simulation model construction method for stimulating a deep brain area by electromagnetic waves, which comprises the following steps: constructing a brain finite element model, a semi-ellipsoid reflection structure and an electromagnetic wave emission source based on a COMSOL simulation software radio frequency module; the semi-ellipsoid reflection structure is located in the external space of the brain and comprises two semi-ellipsoid reflection surfaces with the same major semi-axis and the same minor semi-axis. The second focuses of the two semi-ellipsoid reflecting surfaces coincide in a deep brain region; the electromagnetic wave emission source comprises a lumped power supply port, a first patch antenna and a second patch antenna, wherein the first patch antenna and the second patch antenna are located at first focuses of the two semi-ellipsoid reflecting surfaces respectively. The first patch antenna and the second patch antenna respectively emit two beams of high-frequency carrier electromagnetic waves, and a preset tiny frequency difference exists between the frequencies of the two beams of high-frequency carrier electromagnetic waves. Through the method, a superficial brain region is bypassed, simulation modeling is performed on a deep brain region non-invasive electrical stimulation scheme, and model parameters are optimized.
Owner:INST OF ADVANCED TECH UNIV OF SCI & TECH OF CHINA +1

Clinical test intelligent monitoring system based on big data analysis

The invention relates to the technical field of medical data processing, in particular to a clinical test intelligent monitoring system based on big data analysis, and the system comprises a test data collection module, a test risk assessment module, a risk early warning feedback module and a clinical test database. The test object visiting risk, the test progress abnormal risk and the test object compliance are incorporated into an overall evaluation system of the clinical test, and the transparency and credibility of the clinical test can be enhanced through the comprehensive evaluation system. The credibility of the public on clinical tests is improved, smooth development of the clinical tests and wide acceptance of results are promoted, resource allocation is optimized, and the research efficiency is improved. According to the method, progress delay possibly occurring in the test process is recognized and processed in time, so that a researcher can ensure that the test is carried out according to a plan, and resource waste and cost increase caused by the progress delay are avoided.
Owner:HIPOWER

A method for analyzing the mobility of original formation water in gas reservoirs

ActiveCN116818754BRealize mobility evaluationAvoid costly experimentsNMR - Nuclear magnetic resonanceMathematical model
This invention discloses a method for analyzing the mobility of original formation water in gas reservoirs, comprising the following steps: S1, acquiring target well and target layer image data, and constructing a three-dimensional multi-pore structure model; S2, restoring the original formation conditions to the three-dimensional multi-pore structure model; S3, establishing a gas-water two-phase displacement mathematical model based on the lattice Boltzmann method, and coupling the two to obtain a coupled model; S4, determining the original state of the gas reservoir, setting evolutionary solution conditions, and performing evolutionary calculations on the coupled model based on the evolution equation to obtain a three-dimensional multi-pore structure model containing both gas and water phases; S5, performing multi-angle slice analysis, classifying and analyzing the mobility of the water phase, and obtaining the distribution of mobile water. This method does not require closed coring operations and avoids subsequent high-cost experiments such as nuclear magnetic resonance and core displacement, effectively reducing research costs, providing accurate and reliable prediction results, greatly shortening the testing and analysis cycle, and realizing the evaluation of formation water mobility under the original conditions of gas reservoirs.
Owner:CHINA PETROLEUM & CHEMICAL CORP +1

A method for constructing a natural lipid deposition model of a laying hen liver organoid

ActiveCN119530127Bavoid quality lossHigh fat metabolic activityHepatocytesCell culture supports/coatingBiotechnologyTissue lipid
The application relates to the technical field of cell culture, and discloses a construction method of a laying hen liver organoid natural lipid deposition model, which verifies that the functions related to liver tissue lipid synthesis and transport of 1-day-old laying hens are more active, the separated liver organoids and liver primary cells present the same trend, and there is more lipid deposition, so the organoids cultured by the primary liver cells of 1-day-old laying hens are selected as a kind of natural in-vitro lipid deposition model. In order to solve the technical problem that it is difficult to establish an endogenous lipid deposition model of laying hens, the application improves the organoid inoculation and culture technology by separating the primary liver cells of 1-day-old laying hens, successfully constructs a kind of primary liver cell-derived laying hen liver organoid natural lipid deposition model, reduces the research cost, and has higher lipid metabolism activity, and provides an ideal ex vivo model for the research on laying hen liver lipid metabolism and related disease mechanisms.
Owner:NORTHWEST A & F UNIV

Simulation method, device and equipment of airborne radar target alarm display system

ActiveCN119556583Areduce research costsImprove research efficiencySimulator controlRadarAirplane
The invention provides a simulation method, device and equipment for an airborne radar target alarm display system, and relates to the technical field of simulation, and the method comprises the steps: obtaining initial flight data corresponding to a plurality of simulation airplanes under the condition that a simulation self-inspection result corresponding to the airborne radar target alarm display simulation system is fault-free; target flight data corresponding to the simulation airplanes are determined based on the initial flight data; and performing simulation alarm display on a display interface of the airborne radar target alarm display simulation system based on the flight data of each target. According to the technical scheme, the complete working process of the airborne radar target alarm display system can be simulated without the help of semi-physical hardware equipment, the research cost for the airborne radar target alarm display system is reduced, the research efficiency is improved, and simulation can be carried out for multiple targets (namely simulation airplanes).
Owner:BEIJING BLUESKY AVIATION TECH CO LTD

A 3'-utr element and its use in the production of a protein of interest

PendingCN122278840Apromote gene expressionShort experiment cycleProtein targetNucleotide sequencing
This invention provides a 3'-UTR element and its application in the production of target proteins. The 3'-UTR element comprises: (a) a nucleic acid molecule with a nucleotide sequence as shown in any of SEQ ID NO. 23, SEQ ID NO. 1-SEQ ID NO. 22, SEQ ID NO. 24-SEQ ID NO. 28, and SEQ ID NO. 37; (b) a nucleic acid molecule transcribed using the antisense strand of (a) as a template; or (c) a nucleic acid molecule derived from (a) or (b) by substitution, deletion, or addition of one or more nucleotides in the nucleotide sequence defined by (a) or (b) while retaining the biological function of its derived sequence. This element can stably and significantly enhance mRNA gene expression, providing a powerful tool for the development of mRNA vaccines and the optimization of gene expression in gene therapy.
Owner:SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD +2