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A kind of compound florfenicol preparation for aquatic animals and preparation method thereof

A technology of compound florfenil and florfenicol, which is applied in the field of medicine, can solve the problems of affecting the liver metabolism of aquatic animals, increasing the drug resistance of pathogenic bacteria, economic losses of breeding farms, etc., achieving good application prospects, overcoming drug resistance, The effect of increasing permeability

Active Publication Date: 2020-06-09
长沙施比龙动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the abuse and double use of florfenicol by farmers in recent years, a series of problems have occurred: the drug resistance of pathogenic bacteria has increased year by year; the embryotoxicity has become prominent, causing economic losses to breeding farms; the animal body has immunity Inhibitory effect; increased drug residue; affect liver metabolism of aquatic animals

Method used

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  • A kind of compound florfenicol preparation for aquatic animals and preparation method thereof
  • A kind of compound florfenicol preparation for aquatic animals and preparation method thereof
  • A kind of compound florfenicol preparation for aquatic animals and preparation method thereof

Examples

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Effect test

Embodiment 1

[0030] A kind of compound florfenicol preparation for aquatic animals, its component formula is as follows:

[0031]

[0032]

[0033] The compound Florfenicol preparation for aquatic animals of above-mentioned component formula, its preparation method is as follows:

[0034] (1), each component material is pulverized respectively, and it is standby after crossing 80 mesh sieves;

[0035] (2), take Florfenicol 16kg and pregelatinized starch 16kg, mix;

[0036] (3), in the mixture of above-mentioned florfenicol and pregelatinized starch, add tylvalosin 10kg, glucuronolactone 15kg, 2-deoxyglucose 20kg and remaining 23kg pregelatinized starch successively, fully mix, The compound florfenicol preparation for aquatic animals was obtained.

Embodiment 2

[0038] A kind of compound florfenicol preparation for aquatic animals, its component formula is as follows:

[0039] components Dosage(kg) Florfenicol 20 Tivalamectin 8 Glucuronolactone 10 2-deoxyglucose 16 pregelatinized starch 46

[0040] The compound Florfenicol preparation for aquatic animals of above-mentioned component formula, its preparation method is as follows:

[0041] (1), each component material is pulverized respectively, and it is standby after crossing 80 mesh sieves;

[0042] (2), take Florfenicol 20kg and pregelatinized starch 20kg, mix;

[0043] (3), in the mixture of above-mentioned florfenicol and pregelatinized starch, add 8kg of tyvalactin, 10kg of glucuronolactone, 16kg of 2-deoxyglucose and remaining 26kg of pregelatinized starch successively, fully mix, The compound florfenicol preparation for aquatic animals was obtained.

Embodiment 3

[0045] A kind of compound florfenicol preparation for aquatic animals, its component formula is as follows:

[0046]

[0047]

[0048] The compound Florfenicol preparation for aquatic animals of above-mentioned component formula, its preparation method is as follows:

[0049] (1), each component material is pulverized respectively, and it is standby after crossing 80 mesh sieves;

[0050] (2), take Florfenicol 10kg and pregelatinized starch 10kg, mix;

[0051] (3), in the mixture of above-mentioned florfenicol and pregelatinized starch, add 15kg of tylvalosin, 10kg of glucuronolactone, 12kg of 2-deoxyglucose and remaining 43kg of pregelatinized starch successively, fully mix, The compound florfenicol preparation for aquatic animals was obtained.

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Abstract

The invention relates to the technical field of medicines and particularly discloses a compound florfenicol preparation for aquatic animals and a preparation method of the compound florfenicol preparation for the aquatic animals. The compound florfenicol preparation for the aquatic animals is prepared from, by mass, 10-20% of florfenicol, 5-15% of acetylisovaleryltylosin tartrate, 10-20% of glucurolactone, 12-20% of 2-deoxyglucose and the balance auxiliary materials. The preparation method includes manufacturing steps: drying the auxiliary materials until moisture content is 8% or below, respectively subjecting auxiliary and raw materials to grinding and screening through a 80-mesh screen, and well mixing the screened powdery auxiliary and raw materials in a mixer. The compound florfenicolpreparation for aquatic animals is easy to produce, effective in treatment of bacterial diseases of the aquatic animals, low in drug resistance and effective in protection and repair livers of the aquatic animals. By formula and process optimization, problems of poor treatment effects, high animal liver burden and the like of antibacterial medicines are solved. The compound florfenicol preparation is suitable for aquatic animals and used for treatment of various bacterial diseases.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound florfenicol preparation for aquatic animals and a preparation method thereof. Background technique [0002] my country is a large fishery country. Aquatic products occupy an important position in the national diet because of their low-fat, high-protein, good nutritional balance, and delicious taste. With the continuous expansion of market demand, the total amount and density of aquaculture in my country are also increasing, followed by the increasing frequency of outbreaks of various diseases, and the treatment effect is getting worse. Judging from the current development of my country's aquatic industry, bacterial diseases are more difficult to cure and more likely to recur than other types of diseases. The most common preventive measure for aquatic bacterial diseases is the use of antibacterial drugs. The use of various antibacterial drugs is of great significance...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/165A61K31/7004A61K47/36A61P1/16A61P31/04A61P31/12
CPCA61K31/165A61K31/7004A61K31/7048A61K47/36A61K2300/00
Inventor 张卫元张运超赵宇江李应林王海坤
Owner 长沙施比龙动物药业有限公司
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