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D-glucuronolactone esterification process

A glucuronolactone ester and process technology, which is applied in the field of glucuronolactone esterification process, can solve the problems of large energy consumption and high production cost, and achieve the effects of increasing yield, reducing production cost and high yield

Inactive Publication Date: 2009-05-20
安徽富博医药化工股份有限公司
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The esterification process consumes a large amount of acetic acid, which makes the production cost higher and requires a large amount of energy for the acid distillation unit operation

Method used

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Examples

Experimental program
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Embodiment Construction

[0017] 1. Take 4000ml of large-scale production hydrolyzate and concentrate it in the concentrator to 44-49 degrees Baume, add the compound acid (phosphoric acid + sulfuric acid) reagent to the concentrator in proportion, and add it under stirring to make the compound acid (phosphoric acid + sulfuric acid) The temperature of the esterification solution after the reagent is kept below 35°C;

[0018] 2. After stirring evenly, stand still for esterification; esterification temperature 10-35°C; stand still for 24 hours

[0019] 3. After standing still for esterification, add 130ml of alcohol and stir to enter the crystallization process directly. Cool down to 10-15°C in 0-24 hours and stir for 5 minutes every hour; cool down to below 0°C in 24-48 hours and stir every hour 5min; 48-60 hours to cool down to below -8°C, and stir for 5min every 1 hour; the crystallization solution is suction filtered to obtain the crude product and refined to obtain the finished product of glucuronola...

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Abstract

The invention relates to the further improvement of an esterification technique of glucurolactone, which is characterized by changing acetic acid esterification adopted by the existing esterification technique of glucurolactone into the esterification technique of complex acids (phosphoric acid and sulphuric acid) and comprises the steps that: 4000ml of hydrolyzation solution for mass production is concentrated to 46 Baume degree to 47 Baume degree; the complex acids (phosphoric acid and sulphuric acid) are added into a concentrator while stirring according to a certain proportion so that the esterification temperature after the adding of the reagent of the complex acids is kept below 35 DEG C; after being evenly stirred, the mixture is placed still for esterification under the temperature of 10 DEG C to 35 DEG C; after the esterification is finished, 130ml of alcohol is added to directly enter crystallization operating instructions. The crystallization liquid is pumped and filtered to obtain crude products which are refined to obtain the finished products of glucurolactone; the quality of the finished products far exceeds the standard of current Chinese pharmacopoeia and reaches or even exceeds the standard for medicaments and food additives in developed European countries.

Description

[0001] Technical field: the present invention relates to a kind of esterification process of glucuronolactone. Background technique: [0002] The full name of glucuronolactone in Chinese is glucuronolactone, commonly known as liver Taile, and its molecular formula is C 6 h 8 o 6 , its chemical composition is: D(+)-furanoglucuronic acid γ-lactone, English name: [D(ten)—Glucofuranurono—6,3—lactone]. As a liver detoxifier and immune function regulator, glucuronolactone is a conventional liver-protecting medicine; glucuronolactone and its follow-up products are also the main additives of functional drinks and foods, weight-loss drugs, cosmetic crystals, etc. It has the effects of replenishing physical energy, improving hypoxia, nourishing skin, and delaying aging. [0003] The main method for the current industrial production of glucuronolactone is the nitric acid oxidation method starting from starch. The process is: add starch to nitric acid with a content of about 80% (V / V) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H7/033C07D493/04A61P1/16
Inventor 司福星余茂宽高志风江书斌梁广忠
Owner 安徽富博医药化工股份有限公司
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