Solid effervescent mixture for oral absorption

A technology for oral absorption and effervescent preparations, which is applied in anti-inflammatory agents, anti-toxic agents, food preparation, etc., can solve the problems of low bioavailability, slow drug effect onset, etc., achieve good taste, simple dosage form, and avoid liver first over effect

Inactive Publication Date: 2010-12-22
无锡健而乐医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a solid energy bubble for oral absorption with fast onset of drug effect and high bioavailability for the shortcomings of traditional gastrointestinal absorption oral energy preparations. Sodium preparation

Method used

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  • Solid effervescent mixture for oral absorption
  • Solid effervescent mixture for oral absorption
  • Solid effervescent mixture for oral absorption

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Embodiment 1: oral absorption solid energy effervescent preparation, the weight percentage of each component is:

[0057] Citric acid 5%, sodium bicarbonate 35%, calcium carbonate 15%, D-ribose 0.2%, glucuronolactone 0.3%, ginseng extract 0.5%, PEG 35%, aspartame 0.3%, mint flavor 0.6% , 4% sorbitol, 1% micronized silica gel, and the rest are colorants.

[0058] Preparation:

[0059] a. The above-mentioned citric acid, sodium bicarbonate, calcium carbonate, D-ribose, glucuronolactone, ginseng extract, and sorbitol were respectively pulverized through an 80-mesh sieve;

[0060] b. Mix citric acid, sorbitol and PEG in proportion, heat to 65°C to melt, granulate through a 20-mesh sieve, cool and dry, and set aside;

[0061] c. Mix sodium bicarbonate, calcium carbonate and PEG in proportion, heat to 65°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside;

[0062] d. Mix D-ribose, glucuronolactone, ginseng extract, sorbitol and PEG in propor...

Embodiment 2

[0064] Embodiment 2: oral absorption solid energy effervescent preparation, the weight percentage of each component is:

[0065] Malic acid 50%, sodium carbonate 5%, natural caffeine 5%, ginseng extract 35%, PEG 0.5%, stevioside 0.3%, hawthorn powder 0.9%, PVP 3%, magnesium stearate 0.15%, the rest is coloring agent.

[0066] Preparation:

[0067] a. The above-mentioned malic acid, sodium carbonate, natural caffeine, and ginseng extract are pulverized respectively through an 80-mesh sieve;

[0068] b. Mix malic acid and PEG in proportion, heat to 65°C to melt, granulate through a 20-mesh sieve, cool and dry, and set aside;

[0069] c. Mix sodium carbonate and PEG in proportion, heat to 65°C to melt, granulate through a 20-mesh sieve, cool and dry, and set aside;

[0070] d. Mix natural caffeine, ginseng extract and PEG in proportion, heat to 65°C to melt, granulate through a 20-mesh sieve, cool and dry, and set aside;

[0071] e. Fully mix the components obtained in steps ...

Embodiment 3

[0072] Embodiment 3: oral absorption solid energy effervescent preparation, the weight percentage of each component is:

[0073] Tartaric acid 10%, calcium carbonate 30%, octacosanol 10%, D-ribose 10%, panthenol 16%, PEG 15%, spicy powder 0.8%, mannitol 7%, stevioside 0.2%, talc 0.95% , and the rest are colorants. Preparation:

[0074] a. above-mentioned tartaric acid, calcium carbonate, octacosanol, D-ribose, mannitol are pulverized respectively and cross 80 mesh sieves;

[0075] b. Mix tartaric acid with panthenol and PEG in proportion, heat to 90°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside;

[0076] c. Mix calcium carbonate with panthenol and PEG in proportion, heat to 90°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside;

[0077] d. Mix octacosanol, D-ribose, mannitol with panthenol and PEG in proportion, heat to 90°C and melt, pass through a 20-mesh sieve to granulate, cool and dry, and set aside; ...

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Abstract

The invention relates to an effervescent mixture, specifically relates to a solid effervescent mixture for the oral absorption and a preparation method thereof. The invention comprises the alkalic component of a mixture consisting one or more than one of alkali metal carbonate, alkali metal bicarbonate, alkaline earth metal carbonate or pearl powder; the acid component of a mixture consisting one or more than one of tartaric acid, citric acid, adipic acid, fumaric acid, maleic acid, malic acid, folic acid andacid phosphate; the medical component of a mixture consisting one or more than one of ginseng extract, octacosanol, glucurolactone, taurine, natural caffeine, D-ribose; the wrapper and auxiliary material of a mixture consisting one or more than one of polyethylene glycol (PEG), panthenol and glycerin monostearate. The invention comprises, by weight, 5-50% of alkalic component; 5-50% of acid component; 1-40% of medical component; 0.5-35% of wrapper; 1-10% of auxiliary material. The invention has advantages of being fast in effect, and convenient in medicine taking and carrying.

Description

technical field [0001] The present invention relates to an effervescent preparation, in particular to a solid effervescent preparation, especially a kind of energy effervescent that does not need to be dissolved in water first, and can be absorbed into the blood circulation system through the mucous membranes of the oral cavity, gums, sublingual and other parts after oral administration. Teng preparation and its preparation method. technical background [0002] At present, traditional oral drug dosage forms, including tablets, capsules, oral liquids, etc., are absorbed into the blood circulation system through the gastrointestinal tract to exert their drug effects, and the onset time is usually more than 30 minutes; before the drug enters the blood circulation system, it produces The first-pass effect of the liver and the stimulation of the gastrointestinal mucosa by the drug, various biological enzymes in the gastrointestinal tract and bile will affect the absorption of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/46A61K9/16A61K9/68A61K31/185A61K31/7048A61K36/258A61K31/045A61K31/522A61K31/7004A61K47/34A61K47/18A61K47/14A23L1/29A61P1/14A61P25/00A61P1/16A61P39/00A61P37/04A61P21/00A61P29/00A61P39/02A23L33/00
CPCA61K9/0007A61K31/00A61K9/0056A61P1/02A61P1/14A61P1/16A61P21/00A61P25/00A61P25/34A61P29/00A61P37/04A61P39/00A61P39/02A61P39/06
Inventor 刘双华
Owner 无锡健而乐医药科技有限公司
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