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Complex salt consisting of glucuronic acid or glucurolactone and kushenin or matrine and application thereof

A technology of glucuronic acid and glucuronolactone, which is applied in the field of diseases and can solve problems such as reducing

Inactive Publication Date: 2010-06-09
刘兆平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the deficiency of existing single compound glucuronolactone or glucuronic acid and matrine, matrine in the clinical curative effect and therapeutic range, and to provide a kind of liver disease therapeutic effect better than sodium glucuronate, sodium glucuronate, A double salt of glucuronic acid or glucuronolactone, matrine and / or matrine of any single compound in glucuronolactone, matrine, and matrine and a preparation method thereof, and the double salt is characterized in that Reduce the pH value of matrine and matrine, reduce drug stimulation, and play a synergistic and complementary role between the raw materials for preparing the double salt

Method used

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  • Complex salt consisting of glucuronic acid or glucurolactone and kushenin or matrine and application thereof
  • Complex salt consisting of glucuronic acid or glucurolactone and kushenin or matrine and application thereof
  • Complex salt consisting of glucuronic acid or glucurolactone and kushenin or matrine and application thereof

Examples

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Effect test

Embodiment 1

[0049] Preparation method of glucuronolactone and matrine double salt:

[0050] Add about 5 grams of matrine and glucuronolactone in an equimolar ratio into a 100ml reaction bottle, add 50ml of methanol, heat and stir, reflux in a water bath, add an appropriate amount of water dropwise, reflux for 2h, then concentrate the solution, cool, and refrigerate for 12-24h , precipitated white crystals, filtered, washed, and dried in vacuo to obtain 4.31 g of white solids with a yield of 86.2%.

Embodiment 2

[0052] The preparation method of glucuronolactone and matrine double salt:

[0053] Add approximately 5 grams of matrine and glucuronolactone in an equimolar ratio into a 100ml reaction bottle, add 50ml of acetone, heat and stir, reflux in a water bath, add an appropriate amount of water dropwise, reflux for 2 hours, then concentrate the solution, cool, and refrigerate for 12-24 hours , precipitated white crystals, filtered, washed, and dried in vacuo to obtain 4.16 g of white solids with a yield of 83.2%.

Embodiment 3

[0055] The preparation method of glucuronic acid and matrine double salt:

[0056] Put approximately 5 grams of matrine and glucuronic acid in an equimolar ratio into a 100ml reaction bottle, add 50ml of ethanol, heat and stir, reflux in a water bath, add an appropriate amount of water dropwise, reflux for 2 hours, then concentrate the solution, cool, and refrigerate for 12-24 hours. White crystals were precipitated, filtered, washed, and dried in vacuo to obtain 4.45 g of white solids with a yield of 89.0%.

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Abstract

The invention relates to the medicament field, in particular to a complex salt consisting of glucuronic acid or glucurolactone and kushenin and / or matrine, a method for preparing the complex salt, application of the complex salt in treating liver diseases, in particular the diseases such as hepatitis, hepatic injury, liver cancer and the like, and a complex salt medicament capable of being used as an oral administration dosage form as well as a non-oral administration dosage form. Pharmacodynamic laboratory science for comparing the complex salt with the glucurolactone, sodium glucuronate, the kushenin and the matrine shows that the functions of the complex salt are better than that of using the glucurolactone, the sodium glucuronate, the kushenin and the matrine independently. The enhancement action is proved on a plurality of animal models.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a double salt formed of glucuronic acid or glucuronolactone and matrine and / or matrine, a preparation method of the double salt, and an application of the double salt for treating liver diseases , especially for treating diseases such as hepatitis, liver injury and liver cancer, and the double salt medicine can be used as an oral dosage form and a non-oral dosage form. Background technique [0002] Liver disease is one of the most threatening diseases to human health. At present, there are about 350 million hepatitis B virus carriers in the world, and about 120 million people in China. Its etiology and pathogenesis are extremely complicated, and there is no definite and effective preventive drug for it at present, and many patients have not received effective treatment, which has brought many adverse consequences to society and families. [0003] Matrine and matrine are alkaloids isolat...

Claims

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Application Information

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IPC IPC(8): C07H7/033C07H13/02C07D455/00C07D471/22A61K31/7012A61K31/7042A61K31/4375A61P1/16
Inventor 刘兆平
Owner 刘兆平
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