Process method for producing glucurolactone

Abstract

The invention discloses a process method for producing glucurolactone, and relates to a method for producing the glucurolactone by an improved method of oxidizing starch through nitric acid. The method comprises 1) oxidation, 2) hydrolysis, 3) concentration, 4) esterification and 5) refining. The process method for producing the glucurolactone has the advantages of high yield, good appearance of finished product and low energy consumption.

Description

technical field

[0001] The invention relates to a process for producing Gan Tai Le, in particular to a process for producing Gan Tai Le through an improved nitric acid oxidized starch method. Background technique

[0002] Gantyle (glucuronolactone, Glucurolactone, Glucurone) is clinically used for acute and chronic viral hepatitis, liver cirrhosis, food poisoning and drug poisoning, and can also be used for arthritis and rheumatism.

[0003] my country is the world's main producer of liver tyle, with a domestic production capacity of 3,000 tons per year. At present, the production enterprises of this product all adopt the production process of oxidizing starch with nitric acid. The first step is to oxidize starch with nitric acid to generate gluconic acid. When the full amount of nitric acid is put in, the initial side reaction is large, and the starch is impermeable to oxidation during the reaction period; the second step is the hydrolysis process. If the starch chain is not...

Examples

example 1

[0021] A kind of processing method of producing liver Tylenol, comprising the following steps:

[0022] 1) Weigh 1 kg of starch, and put half of the amount of nitric acid into the reactor at a mass ratio of starch to nitric acid of 10:1.5, add starch, and heat to catalyze the reaction. After reaching equilibrium, add the other half of nitric acid to control The reaction temperature is 50°C, and after the feeding is finished, the reaction temperature is slowly increased;

[0023] 2) The acidity is controlled at 8 ~ 10w / v, and the feed liquid in the hydrolysis pot is heated by direct steam, so that the feed liquid rises to above 140°C in a short time, and it is kept in the hydrolysis pot for 2 hours to complete the hydrolysis and cool down rapidly. At 90°C, add activated carbon for decolorization treatment, and control the light transmittance at 18-20%;

[0024] 3) under high vacuum, low-temperature evaporation and concentration, until the aldehyde content is above 70%;

[002...

technical field

[0001] The invention relates to a process for producing Gan Tai Le, in particular to a process for producing Gan Tai Le through an improved nitric acid oxidized starch method. Background technique

[0002] Gantyle (glucuronolactone, Glucurolactone, Glucurone) is clinically used for acute and chronic viral hepatitis, liver cirrhosis, food poisoning and drug poisoning, and can also be used for arthritis and rheumatism.

[0003] my country is the world's main producer of liver tyle, with a domestic production capacity of 3,000 tons per year. At present, the production enterprises of this product all adopt the production process of oxidizing starch with nitric acid. The first step is to oxidize starch with nitric acid to generate gluconic acid. When the full amount of nitric acid is put in, the initial side reaction is large, and the starch is impermeable to oxidation during the reaction period; the second step is the hydrolysis process. If the starch chain is not...

Examples

example 1

[0021] A kind of processing method of producing liver Tylenol, comprising the following steps:

[0022] 1) Weigh 1 kg of starch, and put half of the amount of nitric acid into the reactor at a mass ratio of starch to nitric acid of 10:1.5, add starch, and heat to catalyze the reaction. After reaching equilibrium, add the other half of nitric acid to control The reaction temperature is 50°C, and after the feeding is finished, the reaction temperature is slowly increased;

[0023] 2) The acidity is controlled at 8 ~ 10w / v, and the feed liquid in the hydrolysis pot is heated by direct steam, so that the feed liquid rises to above 140°C in a short time, and it is kept in the hydrolysis pot for 2 hours to complete the hydrolysis and cool down rapidly. At 90°C, add activated carbon for decolorization treatment, and control the light transmittance at 18-20%;

[0024] 3) under high vacuum, low-temperature evaporation and concentration, until the aldehyde content is above 70%;

[002...