Pantoprazole sodium combined drug

Abstract

The invention discloses a pantoprazole sodium combined drug and a preparation method thereof. The pantoprazole sodium combined drug contains the following active ingredients in parts by weight: 35-100 parts of pantoprazole sodium, 15-35 parts of tiopronin, 90-200 parts of calcium glutamate and 15-25 parts of edetate disodium. The pantoprazole sodium combined drug has the functions of preventing damages caused by pantoprazole sodium to liver and other adverse reactions. The invention has the advantages of high drug quality, stable curative effect and advanced preparation method.

Description

technical field [0001] The invention relates to a combination medicine of pantoprazole sodium and a preparation process thereof. Background technique [0002] The gastric and duodenal mucosa has a natural and perfect mechanism to resist the erosion of gastric acid and pepsin, but when it is damaged by Helicobacter pylori and non-steroidal anti-inflammatory drugs, peptic ulcer disease will occur. Australian scholars Warren and Marshall reveal the etiology, and have H 2 Receptor antagonist therapy drugs are effective in treatment, and 22 years later, the two were awarded the 2005 Nobel Prize in Medicine. In the 1980s, proton pump inhibitor drugs were used to treat peptic ulcer disease, which were more powerful and durable than H2 inhibitors. Pantoprazole sodium is a typical representative drug, which is currently one of the first-line first-line drugs for the treatment of peptic ulcer disease. However, the freeze-dried injection of pantoprazole sodium in the prior art still...

AI Technical Summary

Problems solved by technology

However, the freeze-dried injection of pantoprazole sodium in the prior art still adopts the activated carbon depyrogenation process in the preparation production, resulting in activated carbon microparticles and heavy metal ions remaining in the medicinal liquid, which are brought into the blood of the human body during infusion of Jingmai , bring medicinal damage to the body, and the research of the present invention finds that the pyrogen in the activated carbon adsorption liquid is not thorough. ; Second, activated carbon itself does not depyrogenize and activate

This study also found that the heavy metal ions and iron ions brought by activated carbon are oxidative hazards to the drug; the auxiliary excipient of the freeze-dried injection prepared by the prior art uses low-molecular dextran-40, which has allergic effects on the human body, and some people After dripping a few drops of low-molecular-weight dextran-40 infusion, an allergic reaction occurred. The amount of low-molecular-weight dextran used as an excipient for pantoprazole sodium has reached the minimum amount of allergies, and mannitol is generally used as an excipient. Mannitol has a stimulating adverse reaction to blood vessels; the preparation of pantoprazole sodium in the prior art does not protect the group with sulfur atoms from oxidation, peroxidation, and light in the process of manufacture, storage, transportation, use, and entry into the body. Adverse reactions of this drug caused by oxidation