44results about How to "Stable dose" patented technology

Disclosed are bioluminescent bioreporter integrated circuit devices that detect selected analytes in fluids when implanted in the body of an animal. The device comprises a bioreporter that has been genetically engineered to contain a nucleic acid segment that comprises a cis-activating response element that is responsive to the selected substance operably linked to a gene encoding a bioluminescent reporter polypeptide. In preferred embodiments, the target analyte is glucose, glucagons, or insulin. Exposure of the bioreporter to the target substance causes the response element to up-regulate the nucleic acid sequence encoding the reporter polypeptide to produce a luminescent response that is detected and quantitated. In illustrative embodiments, the bioreporter device is encapsulated on an integrated circuit that is capable of detecting the emitted light, processing the resultant signal, and then remotely reporting the results. Also disclosed are controlled drug delivery systems capable of being directly or indirectly controlled by the detection device that provide drugs such as insulin to the animal in reponse to the amount of target analyte present in the body fluids.

Stable unit dose compositions with high water content are provided. Such unit dose compositions include an aqueous composition having a water activity of from about 0.65 to about 0.95 and a water-soluble container formed from a water-soluble or water-dispersible film material. In one embodiment, the aqueous composition includes water in an amount of 25% to 70% by weight, a surfactant system, and a water binding agent. The surfactant system may include: (1) a linear alkylbenzene sulfonate (LAS) and / or an alcohol ethoxylsulfate (AES), (2) a non-ionic surfactant, and (3) a fatty acid. The unit dose compositions can prevent the enclosed liquid detergent composition with a high level of water content from dissolving or pre-maturely dispersing the water-soluble container.

This invention relates to analogues of auristatins, in particular monomethyl auristatin F (MMAF), as cytotoxic agents, conjugates of such cytotoxic agents with a cell-binding agent, the preparation and the therapeutic uses of these cytotoxic agents and conjugates thereof to arrest or retard abnormal cell growth and / or proliferation.

Stable unit dose compositions with high water content are provided. Such unit dose compositions include an aqueous composition having a water activity of from about 0.60 to about 0.95 and a water-soluble container formed from a water-soluble or water-dispersible film material. In one embodiment, the aqueous composition includes water in an amount of 20% to 70% by weight, a structured surfactant system which is in the form of a lamellar structure, and a salt which promotes the formation of the lamellar structure. The surfactant system may include: (1) a linear alkylbenzene sulfonate (LAS) and / or an alcohol ethoxylsulfate (AES), (2) a non-ionic surfactant, and (3) a fatty acid. The unit dose compositions can prevent the enclosed liquid detergent composition with a high level of water content from dissolving or pre-maturely dispersing the water-soluble container due to the lamellar structure of the composition.

A water-conducting domestic appliance, in particular a domestic dishwasher, the water-conducting domestic appliance including a washing compartment for receiving items therein that are to be subjected to a handling process by the water-conducting domestic appliance; and a detergent dosing system, the detergent dosing system having a detergent dispenser with a receiving compartment, the receiving compartment for receiving at least one cartridge that is configured to hold at least one detergent. The detergent dosing system is formed from a plurality of housing walls and at least one portion of at least one housing wall of the detergent dosing system has thermal insulation.

The purpose of the invention is to provide a Pudilan children's antiviral oral pellet gel and a preparation method thereof. The preparation method comprises the following steps: adopting a gel matrix, extracting Radix Scutellariae, Herba Taraxaci, Corydalis bungeana Turcz. and isatis root, preparing pellets by using extracted effective components, and uniformly dispersing the pellets in a gel. The prepared gel can be a solid gel, a semisolid gel or a xerogel. The method effectively covers the bad smell of medicines, solves the mouthfeel problem of the medicines, and allows the sweet oral pellet gel loved by children to be prepared, and the sweet and smooth mouthfeel of the oral pellet gel makes children easily take the medicine. Traditional Chinese medicines are combined with the gel dosage form to improve the children's administration long-term single dosage form, and the oral pellet gel has the efficacies of heat clearing, detoxification, antibiosis and inflammation prevention, and also has the advantages of high content of the effective component, small administrating dosage, stable preparation and good curative effect.

The invention relates to a soft capsule health food with an auxiliary memory-improving function. The product of the invention employs the following components as main raw materials: fish oil, taurine, zinc gluconate, beeswax, vitamin E, gelatin, glycerol, purified water, caramel and titanium dioxide. The method of the invention comprises the steps of mixing, dissolving gelatin, pelleting, shaping, drying, choosing pills and packaging to obtain the soft capsule. The product of the invention is specially prepared for children, has an auxiliary memory-improving function for children and a health care efficacy of supplementing nutrition for brain, and has the advantages of a high pertinence and an obvious effect of improving memory. In addition, the preparation method of the invention adopts a process which obviates a pill washing step, and the product of the invention has a stable quality and is a health food with good taste and convenience in carrying and eating.

Stable unit dose detergent pacs are provided which are less prone to leakage or breakage and more aesthetically pleasing during handling. The unit dose pacs include a water-soluble container formed from a water-soluble or water-dispersible film and a wash composition encapsulated in the container. According to one embodiment, the wash composition includes an anionic surfactant present at from about 2% to about 35%, a non-ionic surfactant present at from about 2% to about 30%, and a solvent system present at from about 37.5% to about 80%, characterized in that the solvent system is composed of water and a single non-aqueous solvent only, or composed of water, a single non-aqueous solvent, and a residual solvent (less than 5%) only.

The present invention uses the oleanolic acid extracted from ligustrum fruit and zymolyzed dried powder made up by using silkworm chrysalis as main raw material, and adds the auxiliary materials of excipient and vitamins and utilizes a certain preparation process to obtain the invented liver-protecting functional food.

The invention discloses an alprostadil liposome composite medicine, which is a composite medicine comprising the main ingredients, i.e., high-purity alprostadil liposome and a mixture of Aspisol and soldium salicylate with the weight ratio of (85-95): (5-15), and discloses the weight ratio of the raw materials of the ingredients in the composite medicine; the invention further provides a preparation method and quality control of the alprostadil liposome composite medicine; a freeze-dried injection, or an oral preparation, or a spraying agent, or a suppository or an enema of the alprostadil liposome composite medicine is prepared; the chromatographic conditions of the contents of the alprostadil, the prostaglandin A1 and the prostaglandin B1 are measured, and three retention peaks before and after the alprostadil retention peak are the characteristic retention peaks of the supplementary materials of the alprostadil liposome composite medicine provided by the invention; the alprostadil liposome composite medicine is used for treating and preventing the diseases such as coronary heart disease and myocardial infarction, cerebral infarction, hypertension, hyperlipidemia, arteriosclerosis, vasculitis, tumor, hepatitis, aiabetic angiopathy and renal insufficiency, bronchial asthma, pancreatitis, gastric ulcer and vertebrobasilar insufficiency and the like.

The invention discloses a liver-protecting functional food and a preparation method thereof. The liver-protecting functional food is prepared by using oleanolic acid extracted from ligustrum fruit and polysaccharide extracted from poria cocos and lentinula edodes as main raw materials, and by adding the auxiliary materials of excipient and vitamins. The liver-protecting functional food has effective components with definite structure, exact liver protecting effect, stable dosage and preparation form, and obvious effect of preventing and treating liver disease. According to the invention, the functional food can not only reduce the contents of MDA and TG in liver, has the function of protecting liver, is safe and non-toxic, and has no any side effects for long term taking.

A photolithography apparatus is constructed comprising an exposure light source that emits light with a wavelength of 400 nm or less as the exposure light, a reticle with a pattern original image formed therein, an illumination optical system that irradiates light outputted from the exposure light source onto the reticle, a projection optical system that projects the pattern image outputted from the reticle onto a photosensitive plate and an alignment system that positions the reticle and the photosensitive plate. At least some of the synthetic silica glass members composing the illumination optical system, the synthetic silica glass members composing the projection optical system and the reticle consist of synthetic silica glass members which, upon 1x104 pulse irradiation with an ArF excimer laser at an energy density from 0.1 muJ / cm2.p to 200 mJ / cm2.p, have a loss factor of no greater than 0.0050 cm-1 at 193.4 nm measured after irradiation, a hydrogen molecule concentration of from 1x1016 molecules / cm3 to 2x1018 molecules / cm3 and a loss factor of no greater than 0.0020 cm-1 before ultraviolet irradiation.

The invention discloses a formation method of a semiconductor structure. The method comprises the steps of providing a semiconductor substrate which comprises a first region and a second region, forming a first gate structure on the semiconductor substrate in the first region, forming a second gate structure on the semiconductor substrate in the second region, forming a first photoresist layer covering the semiconductor substrate in the second region and the second gate structure, forming a second photoresist layer covering the semiconductor substrate in the first region and the first photoresist layer, performing shallow doping ion implantation on the semiconductor substrate on the two sides of the first gate structure in the first region by taking the second photoresist layer as a barrier layer, and forming a first shallow doping region in the semiconductor substrate on the two sides of the first gate structure. The method is suitable for forming a shallow doping region.

The invention discloses a feedback control method and system for an electronic accelerator irradiation system. The control method includes steps that (1), electrons are collected by an electron collector; (2), the aggregated power is amplified and adjusted to become a voltage signal of 0-10v; (3), an electron beam of 0-60mA outputted by an electron accelerator is proportionally adjusted to correspond to the 0-10v voltage signal; (4), the 0-10v voltage signal is transmitted to an industrial computer through a PLC AD analog module; and (5), the digital signal is calibrated and compared by the industrial computer, and equipment is controlled. The electronic collector of the control system is electrically connected with an electronic modulator through a power transmission line and a current limiting resistor, the electronic modulator is electrically connected with the PLC AD analog module through an optical isolator, and the PLC AD analog module is electrically connected with a PLC and theelectron accelerator. The method and the system are advantaged in that beam intensity can be accurately monitored and controlled, and stability and accuracy of the quality of irradiated products canbe greatly improved.

The present invention relates to a chewing gum formulation that serves as a means for awakening human consciousness and mindfulness to the sensorial subtleties, which in turn strengthens sovereignty such that overall psycho-spirituality is enhanced. More particularly, this invention relates to a dietary supplement consisting of the botanical plant Salvia divinorum as the source substance, including Salvinorin Alpha (A) as its primary active constituent, which is precisely extracted from S. divinorum to achieve a consistent dosing regimen predetermined for standardized efficacies.

Provided is an anode capable of keeping the X-ray dose steady in an X-ray generating tube by preventing a crack in a connecting electrode layer, which electrically connects a target layer and an anode member. The anode includes a first bonding boundary where the connecting electrode layer, which electrically connects the target layer and the anode member, is bonded to a supporting substrate of a target, and a second bonding boundary where the connecting electrode layer is bonded to the anode member in which the connecting electrode layer is formed so that the first bonding boundary and the second bonding boundary are on the same side with respect to the connecting electrode layer.

The invention provides a single-photon 6MeV medical low-energy standing-wave accelerating tube, comprising a cavity chain body, wherein two ends of the cavity chain body are respectively connected with an electron gun and a target body; the side face of the cavity chain body is fixedly connected with a rectangular waveguide; the rectangular waveguide is fixedly connected with a microwave input window and a sputtering ion pump; the electron gun is a grid-control triode electron gun; in comparison with a diode electron gun, the grid-control triode electron gun is additionally provided with a grid; the grid can be used for better controlling beams and fine-tuning the X-ray dosage rate and energy, so that the electron beams can reach a stable state instantly and fast hit the target body, therefore X-rays are generated. The cavity chain body is an accelerating cavity chain consisting of 6-7 accelerating cavities with a beam aperture of 4-6 mm and a coupling cavity; the length of the cavity chain body is 27-33 cm; and according to the accelerating tube manufactured based on the design, the dose can reach the stable state in the beam outgoing moment.

The invention discloses a medical 'zedoary oil' and a manufacturing method for its micro capsule, the zedoary oil is acquired by confecting the beta-elemene, zedoary alcohol, curdione according to a fixed proportion, compared with natural zedoay oil, its effective ingredients content are high, and in virtue of the cooperation among the three, thus it has higher functions for resisting tumor, bacteria, and virusl; the producing method for mciro capsule is: because of increasing the even process, and through controlling the inner circulation in the even process, the particle size of the capsule is controllable between 50nm and 500nm, it can acquire the micro capsule with the uniform particle size, its irregularity is not more than plus and minus 5 nm.

The invention relates to a full-automatic dosing system for electroplating sewage treatment equipment. The full-automatic dosing system comprises a first dosing system for roughly adjusting a dose, a second dosing system for finely adjusting the dose, and a dosing control system for controlling the dose and dosing speed of the first and second dosing systems; the first dosing system and the second dosing system are respectively communicated with a wastewater pipeline for conveying wastewater; and the wastewater pipeline communicated with the second dosing system is positioned at downstream of the wastewater pipeline communicated with the first dosing system. Through the two dosing systems, full-automatic dosing system automatically adds agents into the wastewater, can effectively stabilize the dose of the agents and reduce the fluctuation of the dose, effectively controls the use cost of the agents, and is safe, simple and convenient.

The invention provides a dog MSC exosome preparation and a preparing method thereof. The preparing method includes: preparing exosome-free fetal calf serum, and separating dog MSC exosome. The preparing method has the advantages that the extracted exosome of the dog MSC exosome preparation prepared by the method is small in size, can easily achieve in-vivo circulation and can easily reach woundedtissue; in-vivo dosage stability can be guaranteed by directly using the exosome, the treatment effect is guaranteed to a certain degree, the exosome is free of toxic and side effects, and a foundation is laid for large-scale clinical application; the prepared preparation is applicable to dog experiment models, the dog MSC exosome preparation for treating skin injury is prepared, a dog skin woundcan be repaired by injecting the preparation to the periphery of the wound or directly applying the preparation to the wound surface, inflammation can be inhibited, healing can be accelerated, and scar formation can be reduced.

The invention discloses an integrated field emission X-ray source, comprising a vacuum container, an anode target installed in the vacuum container and an electron gun, wherein the electron gun comprises an emission cathode and a grid, the emission cathode and the anode target are respectively installed at opposite ends in the vacuum container, and the grid is installed between the emission cathode and the anode target; Also included is a feedback control circuit, A feedback control circuit includes an anode current sampling module, scan memory module, A non-linear regulation control module and a gate voltage input module, The input of the anode current sampling module is connected to the anode target electrode, the input of the non-linear regulation control module is connected to the anode current sampling module and the scanning memory module, respectively, and the output of the non-linear regulation control module is connected to the gate electrode through the gate voltage input module. The invention makes the current fluctuation of the X-ray source small, and has excellent X-ray stable emission performance.

The invention relates to the technical field of hydrogen sulfide analyzers, in particular to a hydrogen sulfide analyzer which comprises an analysis device, a content proportioning device is fixedly connected to the top of the analysis device, and a second gas inlet pipe device and a first gas inlet pipe device are arranged on the left side and the right side of the top of the content proportioning device respectively. When air pressure in a pressure adjusting pipe enters an inner cavity of the filtering device, the air pressure enters a hollow flow dividing groove through a pipeline mounting hole, and at the moment, air flow in the hollow flow dividing groove is dispersed into a plurality of second flow dividing grooves from an arc-shaped air outlet plate; in this way, the gas can be further filtered through adsorption carbon plates arranged on the multiple arc-shaped filter plates and the isolation plate, the matching pipe conveys external pure water vapor into the annular gas collection cavity, the detected sulfuration gas is mixed with the vapor, the humidity of the gas analyzed in the later period can be increased, and the detection accuracy is improved. And the hydrogen sulfide can be kept in a pure state, so that the detection accuracy can be improved.

The invention discloses an enema type osmotic treatment device for the nephrology department and relates to the technical field of medical instruments, which solves the problems that in the use process of the existing enema permeation device, the length of an insertion tube cannot be conveniently adjusted in the existing enema treatment, so that the administration position cannot be accurately controlled. Meanwhile, excessive administration easily occurs in the administration process, the pressure in the intestinal tract is excessive, and the use effect is poor, and comprises an insertion tubebody, a set of input pipes are connected to the upper portion of the interior of the insertion pipe body in an inserted mode. And a group of output pipes are fixedly connected to the lower part in the insertion pipe body. According to the device, the device can be well fixed; meanwhile, the penetration length of the input pipe can be freely adjusted to ensure that medicine is administrated at theproper position of the intestinal tract, the medicine administration effect is better. Meanwhile, the pressure in the intestinal tract can be well adjusted through the device, it is ensured that theintestinal tract pressure is at the proper pressure, and the device is easy to use, convenient to operate and better in medicine administration effect.

The invention relates to the technical field of hangover alleviation with pueraria lobata, and in particular, relates to a capsule for alleviating hangover with pueraria lobata and a preparation method thereof; the taking dosage can be conveniently controlled, and at the same time, the capsule is convenient to take, can be easily carried by users, improves the utilization rate, and effectively alleviates the drunkenness phenomenon of the users. The capsule is composed of the following raw materials in parts by weight: 9-15 parts of pueraria lobata, 5-10 parts of hovenia acerba, 5-12 parts of turmeric, 7-15 parts of emblic leafflower fruit, 3-9 parts of pseudo-ginseng, 1-3 parts of a ganoderma lucidum extract, 4-8 parts of chrysanthemum, and 5-9 parts of white hyacinth bean. The preparationmethod includes the following steps: (1) raw material screening; (2) raw material pretreatment; (3) raw material soaking; (4) primary decoction; (5) secondary decoction; (6) decoction for multiple times; (7) concentration treatment; (8) gelatin melting; (9) compression moulding; and (10) post-treatment.

The invention discloses a self-coated non-vascular orifice insertion tube, and belongs to the technical field of medical instruments. The self-coated non-vascular orifice insertion tube comprises a non-vascular orifice insertion tube, and is characterized in that the right end of an outer cylinder body sleeves the outer wall of the left end of an inner cylinder body, an annular piston is arrangedin an annular cavity of the inner cylinder body, the annular piston is connected with the right end of a sleeve, and the left end of the sleeve is connected with an annular top plate; a first compression spring is arranged between the annular piston and the left end wall of the inner cylinder body, the inner wall of the sleeve is provided with a plurality of fixing grooves, grooves corresponding to the fixing grooves are formed in the lower end wall of the annular cavity of the inner cylinder body, a ratchet bar is fixedly arranged in each fixing groove, the outer wall of a positioning wheel is provided with a plurality of arch-shaped protrusions arranged uniformly in a circumference, an arc-shaped groove is formed between every two arc-shaped projections, and the inner side end of a guiding ball abuts in an arc-shaped groove of the positioning wheel. Compared with the prior art, the self-coated non-vascular orifice insertion tube has the advantages of simple structure and reasonable design.